Substitution to hydrophobic linker and formation of host–guest complex enhanced the effect of synthetic transcription factor made of pyrrole−imidazole polyamide

[Display omitted] GAA repeat expansion in the first intron of the frataxin (FXN) gene represses the transcription of FXN, and that induces Friedreich’s ataxia (FRDA). Pyrrole−imidazole polyamides (PIPs) are the class of oligopeptide that targets double-stranded DNA with sequence selectivity. Previou...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Bioorganic & medicinal chemistry 2023-03, Vol.81, p.117208-117208, Article 117208
Hauptverfasser:	Hatanaka, Junnosuke, Hashiya, Kaori, Bando, Toshikazu, Sugiyama, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Friedreich’s ataxia (FRDA) Gene Expression Regulation Humans Imidazoles - pharmacology Nylons - pharmacology Pyrrole−imidazole polyamide (PIP) Repeat expansion disease Therapeutic gene modulation Transcription Factors - genetics Trinucleotide Repeat Expansion
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!