An okra polysaccharide (Abelmoschus esculentus) reinforced green hydrogel based on guar gum and poly-vinyl alcohol double network for controlled release of nanocurcumin
A novel green hydrogel (PGCO) of Okra (Abelmoschus esculentus) mucilage-reinforced poly-vinyl alcohol-guar gum (PG) cross-linked by citric acid containing nanocurcumin (NC) as a model drug is reported. The citric acid (CA) cross-linked hydrogel (PGC) without okra is also prepared. The hydrogels are...
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| Veröffentlicht in: | International journal of biological macromolecules 2023-04, Vol.234, p.123618-123618, Article 123618 |
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| container_title | International journal of biological macromolecules |
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| creator | Deka, Rishikesh Sarmah, Jayanta K. Baruah, Sudeepta Dutta, Rekha Rani |
| description | A novel green hydrogel (PGCO) of Okra (Abelmoschus esculentus) mucilage-reinforced poly-vinyl alcohol-guar gum (PG) cross-linked by citric acid containing nanocurcumin (NC) as a model drug is reported. The citric acid (CA) cross-linked hydrogel (PGC) without okra is also prepared. The hydrogels are characterized using FTIR, XRD, FE-SEM, and TGA techniques. Okra reinforced green hydrogel (PGCO) provided comparable swelling behaviour with better mechanical and thermal properties compared to the neat PGC hydrogel. Network parameters of PGC and PGCO hydrogels are estimated using Flory-Rehner equation and strong correlation between the cross-link density and swelling behaviour is established. 45.68 % NC loading in the PGCO hydrogel is achieved. Release study in phosphate buffer (PB) of pH 7.4 provided sustained release of NC over a period of 100 h. The release study of NC followed primarily the Korsmeyer-Peppas model with less-Fickian diffusional character (n |
| doi_str_mv | 10.1016/j.ijbiomac.2023.123618 |
| format | Article |
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[Display omitted]
•Simple method of synthesis of green hydrogel based on citric acid cross-linking•Okra mucilage improves mechanical and thermal properties.•Network study confirmed good structure-property correlation in the hydrogels.•Nano particulation of curcumin (NC) improved aqueous solubility.•The okra-based green hydrogel exhibited controlled NC release.</description><identifier>ISSN: 0141-8130</identifier><identifier>EISSN: 1879-0003</identifier><identifier>DOI: 10.1016/j.ijbiomac.2023.123618</identifier><identifier>PMID: 36780964</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Abelmoschus - chemistry ; Delayed-Action Preparations - chemistry ; Hydrogels - chemistry ; Nanocurcumin ; Okra-reinforced hydrogel ; Plant Gums - chemistry ; Polyvinyl Alcohol - chemistry ; Sustained release</subject><ispartof>International journal of biological macromolecules, 2023-04, Vol.234, p.123618-123618, Article 123618</ispartof><rights>2023 Elsevier B.V.</rights><rights>Copyright © 2023 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-af6690d946273bbc5fcffcb01b7abd75b0208b26a939887c3ecc8b73e08618ef3</citedby><cites>FETCH-LOGICAL-c368t-af6690d946273bbc5fcffcb01b7abd75b0208b26a939887c3ecc8b73e08618ef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijbiomac.2023.123618$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36780964$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Deka, Rishikesh</creatorcontrib><creatorcontrib>Sarmah, Jayanta K.</creatorcontrib><creatorcontrib>Baruah, Sudeepta</creatorcontrib><creatorcontrib>Dutta, Rekha Rani</creatorcontrib><title>An okra polysaccharide (Abelmoschus esculentus) reinforced green hydrogel based on guar gum and poly-vinyl alcohol double network for controlled release of nanocurcumin</title><title>International journal of biological macromolecules</title><addtitle>Int J Biol Macromol</addtitle><description>A novel green hydrogel (PGCO) of Okra (Abelmoschus esculentus) mucilage-reinforced poly-vinyl alcohol-guar gum (PG) cross-linked by citric acid containing nanocurcumin (NC) as a model drug is reported. The citric acid (CA) cross-linked hydrogel (PGC) without okra is also prepared. The hydrogels are characterized using FTIR, XRD, FE-SEM, and TGA techniques. Okra reinforced green hydrogel (PGCO) provided comparable swelling behaviour with better mechanical and thermal properties compared to the neat PGC hydrogel. Network parameters of PGC and PGCO hydrogels are estimated using Flory-Rehner equation and strong correlation between the cross-link density and swelling behaviour is established. 45.68 % NC loading in the PGCO hydrogel is achieved. Release study in phosphate buffer (PB) of pH 7.4 provided sustained release of NC over a period of 100 h. The release study of NC followed primarily the Korsmeyer-Peppas model with less-Fickian diffusional character (n < 0.5). The average diffusion coefficients of NC and curcumin are found to be 3.52 × 10−5 cm2 s−1, and 3.43 × 10−5 cm2 s−1 respectively demonstrating the quick release of NC in early time, which is a pre-requisite in drug delivery. The study provides initial evidence of the usefulness of okra mucilage in green hydrogel development and drug delivery applications.
[Display omitted]
•Simple method of synthesis of green hydrogel based on citric acid cross-linking•Okra mucilage improves mechanical and thermal properties.•Network study confirmed good structure-property correlation in the hydrogels.•Nano particulation of curcumin (NC) improved aqueous solubility.•The okra-based green hydrogel exhibited controlled NC release.</description><subject>Abelmoschus - chemistry</subject><subject>Delayed-Action Preparations - chemistry</subject><subject>Hydrogels - chemistry</subject><subject>Nanocurcumin</subject><subject>Okra-reinforced hydrogel</subject><subject>Plant Gums - chemistry</subject><subject>Polyvinyl Alcohol - chemistry</subject><subject>Sustained release</subject><issn>0141-8130</issn><issn>1879-0003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFuEzEQhi0EoqHlFSofy2GDvU5s742oooBUiQs9W_bsbOLUawd7t1XeiMesS1quXGak0T__aP6PkEvOlpxx-Xm_9Hvn02hh2bJWLHkrJNdvyIJr1TWMMfGWLBhf8UZzwc7Ih1L2dSrXXL8nZ0IqzTq5WpA_m0jTfbb0kMKxWICdzb5HerVxGMZUYDcXigXmgHGayyea0cchZcCebjNipLtjn9MWA3W21GGKdDvbXMtIbez_-jYPPh4DtQHSLgXap9kFpBGnx5TvaXWjkOKUUwjVIGPA6kTTQKONCeYM8-jjBXk32FDw40s_J3c3X39df29uf377cb25bUBIPTV2kLJjfbeSrRLOwXqAYQDHuFPW9WrtWMu0a6XtRKe1AoEA2imBTNf8cBDn5Orke8jp94xlMqMvgCHYiGkuplWqhihVJ6pUnqSQUykZB3PIfrT5aDgzz5TM3rxSMs-UzIlSXbx8uTG7Eft_a69YquDLSYD10weP2RTwGGvoPiNMpk_-fzeeAB66q34</recordid><startdate>20230415</startdate><enddate>20230415</enddate><creator>Deka, Rishikesh</creator><creator>Sarmah, Jayanta K.</creator><creator>Baruah, Sudeepta</creator><creator>Dutta, Rekha Rani</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20230415</creationdate><title>An okra polysaccharide (Abelmoschus esculentus) reinforced green hydrogel based on guar gum and poly-vinyl alcohol double network for controlled release of nanocurcumin</title><author>Deka, Rishikesh ; Sarmah, Jayanta K. ; Baruah, Sudeepta ; Dutta, Rekha Rani</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-af6690d946273bbc5fcffcb01b7abd75b0208b26a939887c3ecc8b73e08618ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Abelmoschus - chemistry</topic><topic>Delayed-Action Preparations - chemistry</topic><topic>Hydrogels - chemistry</topic><topic>Nanocurcumin</topic><topic>Okra-reinforced hydrogel</topic><topic>Plant Gums - chemistry</topic><topic>Polyvinyl Alcohol - chemistry</topic><topic>Sustained release</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Deka, Rishikesh</creatorcontrib><creatorcontrib>Sarmah, Jayanta K.</creatorcontrib><creatorcontrib>Baruah, Sudeepta</creatorcontrib><creatorcontrib>Dutta, Rekha Rani</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of biological macromolecules</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Deka, Rishikesh</au><au>Sarmah, Jayanta K.</au><au>Baruah, Sudeepta</au><au>Dutta, Rekha Rani</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An okra polysaccharide (Abelmoschus esculentus) reinforced green hydrogel based on guar gum and poly-vinyl alcohol double network for controlled release of nanocurcumin</atitle><jtitle>International journal of biological macromolecules</jtitle><addtitle>Int J Biol Macromol</addtitle><date>2023-04-15</date><risdate>2023</risdate><volume>234</volume><spage>123618</spage><epage>123618</epage><pages>123618-123618</pages><artnum>123618</artnum><issn>0141-8130</issn><eissn>1879-0003</eissn><abstract>A novel green hydrogel (PGCO) of Okra (Abelmoschus esculentus) mucilage-reinforced poly-vinyl alcohol-guar gum (PG) cross-linked by citric acid containing nanocurcumin (NC) as a model drug is reported. The citric acid (CA) cross-linked hydrogel (PGC) without okra is also prepared. The hydrogels are characterized using FTIR, XRD, FE-SEM, and TGA techniques. Okra reinforced green hydrogel (PGCO) provided comparable swelling behaviour with better mechanical and thermal properties compared to the neat PGC hydrogel. Network parameters of PGC and PGCO hydrogels are estimated using Flory-Rehner equation and strong correlation between the cross-link density and swelling behaviour is established. 45.68 % NC loading in the PGCO hydrogel is achieved. Release study in phosphate buffer (PB) of pH 7.4 provided sustained release of NC over a period of 100 h. The release study of NC followed primarily the Korsmeyer-Peppas model with less-Fickian diffusional character (n < 0.5). The average diffusion coefficients of NC and curcumin are found to be 3.52 × 10−5 cm2 s−1, and 3.43 × 10−5 cm2 s−1 respectively demonstrating the quick release of NC in early time, which is a pre-requisite in drug delivery. The study provides initial evidence of the usefulness of okra mucilage in green hydrogel development and drug delivery applications.
[Display omitted]
•Simple method of synthesis of green hydrogel based on citric acid cross-linking•Okra mucilage improves mechanical and thermal properties.•Network study confirmed good structure-property correlation in the hydrogels.•Nano particulation of curcumin (NC) improved aqueous solubility.•The okra-based green hydrogel exhibited controlled NC release.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>36780964</pmid><doi>10.1016/j.ijbiomac.2023.123618</doi><tpages>1</tpages></addata></record> |
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| ispartof | International journal of biological macromolecules, 2023-04, Vol.234, p.123618-123618, Article 123618 |
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| subjects | Abelmoschus - chemistry Delayed-Action Preparations - chemistry Hydrogels - chemistry Nanocurcumin Okra-reinforced hydrogel Plant Gums - chemistry Polyvinyl Alcohol - chemistry Sustained release |
| title | An okra polysaccharide (Abelmoschus esculentus) reinforced green hydrogel based on guar gum and poly-vinyl alcohol double network for controlled release of nanocurcumin |
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