Calf blood flow is augmented in habitually aerobically trained versus untrained postmenopausal women in association with favorable modulation of vasculo‐metabolic interactions
Introduction Menopause is associated with vascular dysfunction and increased risk of developing metabolic syndrome. Associations between vascular and metabolic health, and interactions with aerobic exercise training, are unknown in postmenopausal women (PMW). Methods In habitually aerobically traine...
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| Veröffentlicht in: | Scandinavian journal of medicine & science in sports 2023-06, Vol.33 (6), p.882-893 |
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| creator | Craig, Jennifer Akam, Elizabeth C. Bailey, Stephen J. Ferguson, Richard A. O'Donnell, Emma |
| description | Introduction
Menopause is associated with vascular dysfunction and increased risk of developing metabolic syndrome. Associations between vascular and metabolic health, and interactions with aerobic exercise training, are unknown in postmenopausal women (PMW).
Methods
In habitually aerobically trained PMW (PMWtr; n = 10; 57 ± 1 years; 40 ± 1 mL/kg/min), strain‐gauge plethysmography was used to compare resting and peak calf blood flow (CBFr and CBFpk, respectively) and vascular resistance (CVRr; CVRpk) versus untrained PMW (PMWun; n = 13; 56 ± 1 years; 29 ± 1 mL/kg/min) and premenopausal women (PreM; n = 14; 26 ± 1 years; 40 ± 1 mL/kg/min). Vascular measures were taken before and 1 hour after 45 minutes of aerobic exercise (60% V̇O2peak), a known nitric oxide stimulus. Blood analyses included low‐ (LDLc) and high‐density lipoprotein cholesterol (HDLc), insulin, and glucose.
Results
Pre‐exercise, CBFr and CVRr did not differ (p > 0.05) between PMW groups, nor between PreM and PMWtr. CBFpk was highest (p |
| doi_str_mv | 10.1111/sms.14335 |
| format | Article |
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Menopause is associated with vascular dysfunction and increased risk of developing metabolic syndrome. Associations between vascular and metabolic health, and interactions with aerobic exercise training, are unknown in postmenopausal women (PMW).
Methods
In habitually aerobically trained PMW (PMWtr; n = 10; 57 ± 1 years; 40 ± 1 mL/kg/min), strain‐gauge plethysmography was used to compare resting and peak calf blood flow (CBFr and CBFpk, respectively) and vascular resistance (CVRr; CVRpk) versus untrained PMW (PMWun; n = 13; 56 ± 1 years; 29 ± 1 mL/kg/min) and premenopausal women (PreM; n = 14; 26 ± 1 years; 40 ± 1 mL/kg/min). Vascular measures were taken before and 1 hour after 45 minutes of aerobic exercise (60% V̇O2peak), a known nitric oxide stimulus. Blood analyses included low‐ (LDLc) and high‐density lipoprotein cholesterol (HDLc), insulin, and glucose.
Results
Pre‐exercise, CBFr and CVRr did not differ (p > 0.05) between PMW groups, nor between PreM and PMWtr. CBFpk was highest (p < 0.05) and CVRpk was lowest (p < 0.05) in PMWtr. Blood markers were similar (p > 0.05) in PMW groups. However, in PMWtr, CBFpk was associated inversely (p < 0.05) with insulin (r = −0.725). Conversely, in PMWun, CBFpk correlated (p < 0.05) inversely with glucose (r = −0.717), positively with HDLc (r = 0.633), and CVRpk positively (p < 0.05) with LDLc (r = 0.568). Post‐exercise, CBF increased and CVR decreased (p < 0.05) in all groups, yet CBFpk remained higher and CVRpk lower (p < 0.05) in PMWtr.
Conclusion
In untrained PMW, peak CBF is associated inversely with circulating pro‐atherogenic lipids and glucose. In contrast, peak CBF is associated inversely with insulin levels only in trained PMW. Habitual aerobic exercise may favorably modulate vasculo‐metabolic interactions in PMW.]]></description><identifier>ISSN: 0905-7188</identifier><identifier>EISSN: 1600-0838</identifier><identifier>DOI: 10.1111/sms.14335</identifier><identifier>PMID: 36785894</identifier><language>eng</language><publisher>Denmark: Blackwell Publishing Ltd</publisher><subject>Aerobics ; Cholesterol, HDL ; endothelial function ; estrogen deficiency ; Exercise ; Female ; Glucose ; Humans ; Insulin ; lipids ; metabolic ; Metabolism ; Physical fitness ; Plethysmography ; Postmenopause - physiology</subject><ispartof>Scandinavian journal of medicine & science in sports, 2023-06, Vol.33 (6), p.882-893</ispartof><rights>2023 The Authors. published by John Wiley & Sons Ltd.</rights><rights>2023 The Authors. Scandinavian Journal of Medicine & Science In Sports published by John Wiley & Sons Ltd.</rights><rights>2023. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3485-9bd5d364c47fb589e59544f4c48529ffbfe4ae70054512cd86658197cacaf833</cites><orcidid>0000-0002-8784-3742 ; 0000-0002-4037-4213</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fsms.14335$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fsms.14335$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>315,782,786,1419,27931,27932,45581,45582</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36785894$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Craig, Jennifer</creatorcontrib><creatorcontrib>Akam, Elizabeth C.</creatorcontrib><creatorcontrib>Bailey, Stephen J.</creatorcontrib><creatorcontrib>Ferguson, Richard A.</creatorcontrib><creatorcontrib>O'Donnell, Emma</creatorcontrib><title>Calf blood flow is augmented in habitually aerobically trained versus untrained postmenopausal women in association with favorable modulation of vasculo‐metabolic interactions</title><title>Scandinavian journal of medicine & science in sports</title><addtitle>Scand J Med Sci Sports</addtitle><description><![CDATA[Introduction
Menopause is associated with vascular dysfunction and increased risk of developing metabolic syndrome. Associations between vascular and metabolic health, and interactions with aerobic exercise training, are unknown in postmenopausal women (PMW).
Methods
In habitually aerobically trained PMW (PMWtr; n = 10; 57 ± 1 years; 40 ± 1 mL/kg/min), strain‐gauge plethysmography was used to compare resting and peak calf blood flow (CBFr and CBFpk, respectively) and vascular resistance (CVRr; CVRpk) versus untrained PMW (PMWun; n = 13; 56 ± 1 years; 29 ± 1 mL/kg/min) and premenopausal women (PreM; n = 14; 26 ± 1 years; 40 ± 1 mL/kg/min). Vascular measures were taken before and 1 hour after 45 minutes of aerobic exercise (60% V̇O2peak), a known nitric oxide stimulus. Blood analyses included low‐ (LDLc) and high‐density lipoprotein cholesterol (HDLc), insulin, and glucose.
Results
Pre‐exercise, CBFr and CVRr did not differ (p > 0.05) between PMW groups, nor between PreM and PMWtr. CBFpk was highest (p < 0.05) and CVRpk was lowest (p < 0.05) in PMWtr. Blood markers were similar (p > 0.05) in PMW groups. However, in PMWtr, CBFpk was associated inversely (p < 0.05) with insulin (r = −0.725). Conversely, in PMWun, CBFpk correlated (p < 0.05) inversely with glucose (r = −0.717), positively with HDLc (r = 0.633), and CVRpk positively (p < 0.05) with LDLc (r = 0.568). Post‐exercise, CBF increased and CVR decreased (p < 0.05) in all groups, yet CBFpk remained higher and CVRpk lower (p < 0.05) in PMWtr.
Conclusion
In untrained PMW, peak CBF is associated inversely with circulating pro‐atherogenic lipids and glucose. In contrast, peak CBF is associated inversely with insulin levels only in trained PMW. Habitual aerobic exercise may favorably modulate vasculo‐metabolic interactions in PMW.]]></description><subject>Aerobics</subject><subject>Cholesterol, HDL</subject><subject>endothelial function</subject><subject>estrogen deficiency</subject><subject>Exercise</subject><subject>Female</subject><subject>Glucose</subject><subject>Humans</subject><subject>Insulin</subject><subject>lipids</subject><subject>metabolic</subject><subject>Metabolism</subject><subject>Physical fitness</subject><subject>Plethysmography</subject><subject>Postmenopause - physiology</subject><issn>0905-7188</issn><issn>1600-0838</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp1kc9u1DAQhy0EokvhwAsgS1zgkNZe24lzRCv-SUUc2ns0cWzqyokXT7yrvfEIvAqv1Cept2k5IOGLPfY3n8b6EfKaszNe1jmOeMalEOoJWfGasYppoZ-SFWuZqhqu9Ql5gXjDGG9aqZ6TE1E3WulWrsifDQRH-xDjQF2Ie-qRQv4x2mm2A_UTvYbezxlCOFCwKfbe3J_nBH4qxM4mzEjz9HixjTiX7riFjBDoPpbi6AHEaDzMPk507-dr6mAXE_TB0jEOOSwv0dEdoMkh3v76PdoZ-hi8Kf2zTWCOCL4kzxwEtK8e9lNy9enj1eZLdfH989fNh4vKCKlV1faDGkQtjWxcX_5qVaukdKXWat061zsrwTaMKan42gy6rpXmbWPAgNNCnJJ3i3ab4s9sce5Gj8aGAJONGbt109SKC9bIgr79B72JOU1luG6tudBMMK4L9X6hTIqIybpum_wI6dBx1h1j7EqM3X2MhX3zYMz9aIe_5GNuBThfgL0P9vB_U3f57XJR3gH-J60f</recordid><startdate>202306</startdate><enddate>202306</enddate><creator>Craig, Jennifer</creator><creator>Akam, Elizabeth C.</creator><creator>Bailey, Stephen J.</creator><creator>Ferguson, Richard A.</creator><creator>O'Donnell, Emma</creator><general>Blackwell Publishing Ltd</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8784-3742</orcidid><orcidid>https://orcid.org/0000-0002-4037-4213</orcidid></search><sort><creationdate>202306</creationdate><title>Calf blood flow is augmented in habitually aerobically trained versus untrained postmenopausal women in association with favorable modulation of vasculo‐metabolic interactions</title><author>Craig, Jennifer ; Akam, Elizabeth C. ; Bailey, Stephen J. ; Ferguson, Richard A. ; O'Donnell, Emma</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3485-9bd5d364c47fb589e59544f4c48529ffbfe4ae70054512cd86658197cacaf833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Aerobics</topic><topic>Cholesterol, HDL</topic><topic>endothelial function</topic><topic>estrogen deficiency</topic><topic>Exercise</topic><topic>Female</topic><topic>Glucose</topic><topic>Humans</topic><topic>Insulin</topic><topic>lipids</topic><topic>metabolic</topic><topic>Metabolism</topic><topic>Physical fitness</topic><topic>Plethysmography</topic><topic>Postmenopause - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Craig, Jennifer</creatorcontrib><creatorcontrib>Akam, Elizabeth C.</creatorcontrib><creatorcontrib>Bailey, Stephen J.</creatorcontrib><creatorcontrib>Ferguson, Richard A.</creatorcontrib><creatorcontrib>O'Donnell, Emma</creatorcontrib><collection>Wiley Online Library (Open Access Collection)</collection><collection>Wiley Online Library (Open Access Collection)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian journal of medicine & science in sports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Craig, Jennifer</au><au>Akam, Elizabeth C.</au><au>Bailey, Stephen J.</au><au>Ferguson, Richard A.</au><au>O'Donnell, Emma</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Calf blood flow is augmented in habitually aerobically trained versus untrained postmenopausal women in association with favorable modulation of vasculo‐metabolic interactions</atitle><jtitle>Scandinavian journal of medicine & science in sports</jtitle><addtitle>Scand J Med Sci Sports</addtitle><date>2023-06</date><risdate>2023</risdate><volume>33</volume><issue>6</issue><spage>882</spage><epage>893</epage><pages>882-893</pages><issn>0905-7188</issn><eissn>1600-0838</eissn><abstract><![CDATA[Introduction
Menopause is associated with vascular dysfunction and increased risk of developing metabolic syndrome. Associations between vascular and metabolic health, and interactions with aerobic exercise training, are unknown in postmenopausal women (PMW).
Methods
In habitually aerobically trained PMW (PMWtr; n = 10; 57 ± 1 years; 40 ± 1 mL/kg/min), strain‐gauge plethysmography was used to compare resting and peak calf blood flow (CBFr and CBFpk, respectively) and vascular resistance (CVRr; CVRpk) versus untrained PMW (PMWun; n = 13; 56 ± 1 years; 29 ± 1 mL/kg/min) and premenopausal women (PreM; n = 14; 26 ± 1 years; 40 ± 1 mL/kg/min). Vascular measures were taken before and 1 hour after 45 minutes of aerobic exercise (60% V̇O2peak), a known nitric oxide stimulus. Blood analyses included low‐ (LDLc) and high‐density lipoprotein cholesterol (HDLc), insulin, and glucose.
Results
Pre‐exercise, CBFr and CVRr did not differ (p > 0.05) between PMW groups, nor between PreM and PMWtr. CBFpk was highest (p < 0.05) and CVRpk was lowest (p < 0.05) in PMWtr. Blood markers were similar (p > 0.05) in PMW groups. However, in PMWtr, CBFpk was associated inversely (p < 0.05) with insulin (r = −0.725). Conversely, in PMWun, CBFpk correlated (p < 0.05) inversely with glucose (r = −0.717), positively with HDLc (r = 0.633), and CVRpk positively (p < 0.05) with LDLc (r = 0.568). Post‐exercise, CBF increased and CVR decreased (p < 0.05) in all groups, yet CBFpk remained higher and CVRpk lower (p < 0.05) in PMWtr.
Conclusion
In untrained PMW, peak CBF is associated inversely with circulating pro‐atherogenic lipids and glucose. In contrast, peak CBF is associated inversely with insulin levels only in trained PMW. Habitual aerobic exercise may favorably modulate vasculo‐metabolic interactions in PMW.]]></abstract><cop>Denmark</cop><pub>Blackwell Publishing Ltd</pub><pmid>36785894</pmid><doi>10.1111/sms.14335</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-8784-3742</orcidid><orcidid>https://orcid.org/0000-0002-4037-4213</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Scandinavian journal of medicine & science in sports, 2023-06, Vol.33 (6), p.882-893 |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Aerobics Cholesterol, HDL endothelial function estrogen deficiency Exercise Female Glucose Humans Insulin lipids metabolic Metabolism Physical fitness Plethysmography Postmenopause - physiology |
| title | Calf blood flow is augmented in habitually aerobically trained versus untrained postmenopausal women in association with favorable modulation of vasculo‐metabolic interactions |
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