The hybrid protein BTH2 suppresses allergic airway inflammation in a murine model of HDM‐specific immunotherapy

Background Allergen‐specific immunotherapy (AIT) is the only disease‐modifying treatment approach to change disease‐causing allergens. Hypoallergenic derivatives show promise as potential therapeutics, amongst which BTH2 was designed to induce tolerance against Blomia tropicalis allergy. Our aim was...

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Veröffentlicht in:	Clinical and experimental allergy 2023-08, Vol.53 (8), p.821-832
Hauptverfasser:	Silva, Eduardo Santos, Santana, Marina Borges Rabelo, Silveira, Elisânia Fontes, Torres, Rogério Tanan, Silva, Raphael Chagas, Fernandes, Antônio Márcio Santana, Belitardo, Emília Maria Medeiros de Andrade, Garcés, Luis Fabián Salazar, Santiago, Leonardo Freire, Urrego, Juan Ricardo, Vilas‐Bôas, Deise Souza, Freitas, Luiz Antônio Rodrigues, Zakzuk, Josefina, Pacheco, Luis Gustavo Carvalho, Cruz, Álvaro Augusto, Ferreira, Fatima, Cooper, Philip, Caraballo, Luis, Pinheiro, Carina da Silva, Alcantara‐Neves, Neuza Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	allergen immunotherapy Allergens Allergies Animal models Asthma Blo t 5 antigen Blocking antibodies Blomia tropicalis Cytokines Enzyme-linked immunosorbent assay experimental model Goblet cells Immunoglobulin E Immunoglobulin G Immunological tolerance Immunoregulation Immunotherapy Inflammation Leukocytes (eosinophilic) Lymphocytes T peripheral blood mononuclear cell Recombinants Respiratory tract diseases vaccine candidate
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