Silver sulfide coated alginate radioenhancer for enhanced X-ray radiation therapy of breast cancer
A wide range of high-Z nanomaterials are fabricated to decrease radiation dose by sensitizing cells to irradiation through various mechanisms such as ROS generation enhancement. Alginate-coated silver sulfide nanoparticles (Ag2S@Alg) were synthesized and characterized by SEM, TEM, DLS, XRD, EPS, FT-...
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| Veröffentlicht in: | International journal of biological macromolecules 2023-04, Vol.234, p.123636-123636, Article 123636 |
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| container_title | International journal of biological macromolecules |
| container_volume | 234 |
| creator | Mousazadeh, Navid Seidi, Farzad Ghaffarlou, Mohammadreza Rashidzadeh, Hamid Hosseinmirzaei, Ali Mozafari, Faezeh Danafar, Hossein Nosrati, Hamed |
| description | A wide range of high-Z nanomaterials are fabricated to decrease radiation dose by sensitizing cells to irradiation through various mechanisms such as ROS generation enhancement. Alginate-coated silver sulfide nanoparticles (Ag2S@Alg) were synthesized and characterized by SEM, TEM, DLS, XRD, EPS, FT-IR, and UV–vis analysis techniques. Cytotoxicity of nanoparticles was tested against HFF-2, MCF-7, and 4 T1 cell lines for biocompatibility and radio enhancement ability evaluation, respectively. Moreover, the hemolysis assay demonstrated that the nanoparticles were biocompatible and nontoxic. In vitro intracellular ROS generation and calcein AM/PI co-staining unveiled cancerous cell death induction by nanoradiosensitizer, Ag2S@Alg. Further, histopathology results emphasized the tumor ablation capability of Ag2S@Alg. Silver anticancer properties were also recognized and combined with its radiosensitizing effect under X-ray irradiation. |
| doi_str_mv | 10.1016/j.ijbiomac.2023.123636 |
| format | Article |
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Alginate-coated silver sulfide nanoparticles (Ag2S@Alg) were synthesized and characterized by SEM, TEM, DLS, XRD, EPS, FT-IR, and UV–vis analysis techniques. Cytotoxicity of nanoparticles was tested against HFF-2, MCF-7, and 4 T1 cell lines for biocompatibility and radio enhancement ability evaluation, respectively. Moreover, the hemolysis assay demonstrated that the nanoparticles were biocompatible and nontoxic. In vitro intracellular ROS generation and calcein AM/PI co-staining unveiled cancerous cell death induction by nanoradiosensitizer, Ag2S@Alg. Further, histopathology results emphasized the tumor ablation capability of Ag2S@Alg. Silver anticancer properties were also recognized and combined with its radiosensitizing effect under X-ray irradiation.</description><identifier>ISSN: 0141-8130</identifier><identifier>EISSN: 1879-0003</identifier><identifier>DOI: 10.1016/j.ijbiomac.2023.123636</identifier><identifier>PMID: 36775221</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Alginate ; Alginates ; Breast Cancer ; Breast Neoplasms - pathology ; Breast Neoplasms - radiotherapy ; Female ; Humans ; Metal Nanoparticles - therapeutic use ; Nanoparticle ; Radiosensitizer ; Radiotherapy ; Reactive Oxygen Species ; Silver ; Spectroscopy, Fourier Transform Infrared ; X-Rays</subject><ispartof>International journal of biological macromolecules, 2023-04, Vol.234, p.123636-123636, Article 123636</ispartof><rights>2023</rights><rights>Copyright © 2023. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-d72ec164f9f57a5f8a8f8095ea79a0d96cd0314289cf27468a594693ece39e853</citedby><cites>FETCH-LOGICAL-c368t-d72ec164f9f57a5f8a8f8095ea79a0d96cd0314289cf27468a594693ece39e853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijbiomac.2023.123636$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36775221$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mousazadeh, Navid</creatorcontrib><creatorcontrib>Seidi, Farzad</creatorcontrib><creatorcontrib>Ghaffarlou, Mohammadreza</creatorcontrib><creatorcontrib>Rashidzadeh, Hamid</creatorcontrib><creatorcontrib>Hosseinmirzaei, Ali</creatorcontrib><creatorcontrib>Mozafari, Faezeh</creatorcontrib><creatorcontrib>Danafar, Hossein</creatorcontrib><creatorcontrib>Nosrati, Hamed</creatorcontrib><title>Silver sulfide coated alginate radioenhancer for enhanced X-ray radiation therapy of breast cancer</title><title>International journal of biological macromolecules</title><addtitle>Int J Biol Macromol</addtitle><description>A wide range of high-Z nanomaterials are fabricated to decrease radiation dose by sensitizing cells to irradiation through various mechanisms such as ROS generation enhancement. 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Silver anticancer properties were also recognized and combined with its radiosensitizing effect under X-ray irradiation.</description><subject>Alginate</subject><subject>Alginates</subject><subject>Breast Cancer</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast Neoplasms - radiotherapy</subject><subject>Female</subject><subject>Humans</subject><subject>Metal Nanoparticles - therapeutic use</subject><subject>Nanoparticle</subject><subject>Radiosensitizer</subject><subject>Radiotherapy</subject><subject>Reactive Oxygen Species</subject><subject>Silver</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><subject>X-Rays</subject><issn>0141-8130</issn><issn>1879-0003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1PGzEQhq0K1KS0fwH5yGVTf6y99q0VogUJiUNB4mZN7HHjaLNO7Q1S_n03JHDl5PHoeWc0DyGXnC044_r7epHWy5Q34BeCCbngQmqpP5E5N51tGGPyjMwZb3ljuGQz8qXW9dTVipvPZCZ11ykh-Jws_6T-BQutuz6mgNRnGDFQ6P-mYapogZAyDisY_ETFXOjpE-hzU2D_CsCY8kDHFRbY7mmOdFkQ6kj9a-orOY_QV_x2ei_I06-bx-vb5v7h9931z_vGS23GJnQCPddttFF1oKIBEw2zCqGzwILVPjDJW2Gsj6JrtQFlW20lepQWjZIX5Oo4d1vyvx3W0W1S9dj3MGDeVSemm60SrRITqo-oL7nWgtFtS9pA2TvO3MGvW7s3v-7g1x39TsHL047dcoPhPfYmdAJ-HAGcLn1JWFz1CQ--UkE_upDTRzv-Azm-j8o</recordid><startdate>20230415</startdate><enddate>20230415</enddate><creator>Mousazadeh, Navid</creator><creator>Seidi, Farzad</creator><creator>Ghaffarlou, Mohammadreza</creator><creator>Rashidzadeh, Hamid</creator><creator>Hosseinmirzaei, Ali</creator><creator>Mozafari, Faezeh</creator><creator>Danafar, Hossein</creator><creator>Nosrati, Hamed</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20230415</creationdate><title>Silver sulfide coated alginate radioenhancer for enhanced X-ray radiation therapy of breast cancer</title><author>Mousazadeh, Navid ; Seidi, Farzad ; Ghaffarlou, Mohammadreza ; Rashidzadeh, Hamid ; Hosseinmirzaei, Ali ; Mozafari, Faezeh ; Danafar, Hossein ; Nosrati, Hamed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-d72ec164f9f57a5f8a8f8095ea79a0d96cd0314289cf27468a594693ece39e853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Alginate</topic><topic>Alginates</topic><topic>Breast Cancer</topic><topic>Breast Neoplasms - pathology</topic><topic>Breast Neoplasms - radiotherapy</topic><topic>Female</topic><topic>Humans</topic><topic>Metal Nanoparticles - therapeutic use</topic><topic>Nanoparticle</topic><topic>Radiosensitizer</topic><topic>Radiotherapy</topic><topic>Reactive Oxygen Species</topic><topic>Silver</topic><topic>Spectroscopy, Fourier Transform Infrared</topic><topic>X-Rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mousazadeh, Navid</creatorcontrib><creatorcontrib>Seidi, Farzad</creatorcontrib><creatorcontrib>Ghaffarlou, Mohammadreza</creatorcontrib><creatorcontrib>Rashidzadeh, Hamid</creatorcontrib><creatorcontrib>Hosseinmirzaei, Ali</creatorcontrib><creatorcontrib>Mozafari, Faezeh</creatorcontrib><creatorcontrib>Danafar, Hossein</creatorcontrib><creatorcontrib>Nosrati, Hamed</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of biological macromolecules</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mousazadeh, Navid</au><au>Seidi, Farzad</au><au>Ghaffarlou, Mohammadreza</au><au>Rashidzadeh, Hamid</au><au>Hosseinmirzaei, Ali</au><au>Mozafari, Faezeh</au><au>Danafar, Hossein</au><au>Nosrati, Hamed</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Silver sulfide coated alginate radioenhancer for enhanced X-ray radiation therapy of breast cancer</atitle><jtitle>International journal of biological macromolecules</jtitle><addtitle>Int J Biol Macromol</addtitle><date>2023-04-15</date><risdate>2023</risdate><volume>234</volume><spage>123636</spage><epage>123636</epage><pages>123636-123636</pages><artnum>123636</artnum><issn>0141-8130</issn><eissn>1879-0003</eissn><abstract>A wide range of high-Z nanomaterials are fabricated to decrease radiation dose by sensitizing cells to irradiation through various mechanisms such as ROS generation enhancement. 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| ispartof | International journal of biological macromolecules, 2023-04, Vol.234, p.123636-123636, Article 123636 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Alginate Alginates Breast Cancer Breast Neoplasms - pathology Breast Neoplasms - radiotherapy Female Humans Metal Nanoparticles - therapeutic use Nanoparticle Radiosensitizer Radiotherapy Reactive Oxygen Species Silver Spectroscopy, Fourier Transform Infrared X-Rays |
| title | Silver sulfide coated alginate radioenhancer for enhanced X-ray radiation therapy of breast cancer |
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