A universal and sensitive gene mutation detection method based on CRISPR-Cas12a

Single nucleotide mutations are highly related to the occurrence and development of cancer. The development of simple single nucleotide mutation detection methods with high sensitivity and specificity has great clinical significance for the prevention, diagnosis, treatment and prognosis evaluation o...

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Veröffentlicht in:	Analytica chimica acta 2023-03, Vol.1246, p.340886-340886, Article 340886
Hauptverfasser:	Wang, Huajing, Liu, Ruijie, Dong, Kejun, Zhang, Lei, Zhang, Jingxi, Zhang, Xiaoping, Zhang, Jiarui, Xiao, Xianjin, Zhang, Wei, Wang, Xinyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Clinical Relevance CRISPR-Cas Systems - genetics CRISPR-Cas12a Gene mutation Mutation Nucleic Acid Amplification Techniques Nucleotides Polymerase Chain Reaction Sensitivity Specific PCR Universality
Online-Zugang:	Volltext
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