Muscleblind‐like 2 knockout shifts adducin 1 isoform expression and alters dendritic spine dynamics of cortical neurons during brain development

Aims Muscleblind‐like 2 (MBNL2) plays a crucial role in regulating alternative splicing during development and mouse loss of MBNL2 recapitulates brain phenotypes in myotonic dystrophy (DM). However, the mechanisms underlying DM neuropathogenesis during brain development remain unclear. In this study...

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Veröffentlicht in:	Neuropathology and applied neurobiology 2023-04, Vol.49 (2), p.e12890-n/a
Hauptverfasser:	Huang, Chia‐Wei, Lee, Kuang‐Yung, Lin, Peng‐Tzu, Nian, Fang‐Shin, Cheng, Haw‐Yuan, Chang, Chien‐Hui, Liao, Cheng‐Yen, Su, Yen‐Lin, Seah, Carol, Li, Ching, Chen, Yu‐Fu, Lee, Mei‐Hsuan, Tsai, Jin‐Wu
Format:	Artikel
Sprache:	eng
Schlagworte:	Add1 Adducin Alternative splicing Animal models Animals Brain Brain - pathology Brain slice preparation dendritic spine Dendritic spines Dendritic Spines - metabolism Dendritic Spines - pathology Electroporation Fetuses Homeostasis Mice muscleblind‐like Myotonic dystrophy Myotonic Dystrophy - genetics Neonates neural development Neural stem cells Neuropathogenesis Phenotypes Protein Isoforms - metabolism Recombinase Spectrin
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