The impact of epigenetic mechanisms in migraine: Current knowledge and future directions
Background Epigenetic mechanisms, including DNA methylation, microRNAs and histone modifications, may modulate the genetic expression in migraine and its interaction with internal and external factors, such as lifestyle and environmental changes. Objective To summarize, contextualize and critically...
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| Veröffentlicht in: | Cephalalgia 2023-02, Vol.43 (2), p.3331024221145916-3331024221145916 |
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| container_issue | 2 |
| container_start_page | 3331024221145916 |
| container_title | Cephalalgia |
| container_volume | 43 |
| creator | Gallardo, Víctor José Vila-Pueyo, Marta Pozo-Rosich, Patricia |
| description | Background
Epigenetic mechanisms, including DNA methylation, microRNAs and histone modifications, may modulate the genetic expression in migraine and its interaction with internal and external factors, such as lifestyle and environmental changes.
Objective
To summarize, contextualize and critically analyze the published literature on the current state of epigenetic mechanisms in migraine in a narrative review.
Findings
The studies published to date have used different approaches and methodologies to determine the role of epigenetic mechanisms in migraine. Epigenetic changes seem to be involved in migraine and are increasing our knowledge of the disease.
Conclusions
Changes in DNA methylation, microRNA expression and histone modifications could be utilized as biomarkers that would be highly valuable for patient stratification, molecular diagnosis, and precision medicine in migraine. |
| doi_str_mv | 10.1177/03331024221145916 |
| format | Article |
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Epigenetic mechanisms, including DNA methylation, microRNAs and histone modifications, may modulate the genetic expression in migraine and its interaction with internal and external factors, such as lifestyle and environmental changes.
Objective
To summarize, contextualize and critically analyze the published literature on the current state of epigenetic mechanisms in migraine in a narrative review.
Findings
The studies published to date have used different approaches and methodologies to determine the role of epigenetic mechanisms in migraine. Epigenetic changes seem to be involved in migraine and are increasing our knowledge of the disease.
Conclusions
Changes in DNA methylation, microRNA expression and histone modifications could be utilized as biomarkers that would be highly valuable for patient stratification, molecular diagnosis, and precision medicine in migraine.</description><identifier>ISSN: 0333-1024</identifier><identifier>EISSN: 1468-2982</identifier><identifier>DOI: 10.1177/03331024221145916</identifier><identifier>PMID: 36759209</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>DNA Methylation ; Epigenesis, Genetic ; Gene Expression ; Humans ; MicroRNAs - genetics ; Migraine Disorders - genetics</subject><ispartof>Cephalalgia, 2023-02, Vol.43 (2), p.3331024221145916-3331024221145916</ispartof><rights>The Author(s) 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c383t-9e93383ef560a8e2e1a17c00f96fb7a8e90254e9054b75c2296ebf73ec5b311e3</citedby><cites>FETCH-LOGICAL-c383t-9e93383ef560a8e2e1a17c00f96fb7a8e90254e9054b75c2296ebf73ec5b311e3</cites><orcidid>0000-0003-0652-2988 ; 0000-0002-3042-2007 ; 0000-0003-0796-4702</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/03331024221145916$$EPDF$$P50$$Gsage$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/03331024221145916$$EHTML$$P50$$Gsage$$Hfree_for_read</linktohtml><link.rule.ids>313,314,776,780,788,21945,27830,27899,27901,27902,44921,45309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36759209$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gallardo, Víctor José</creatorcontrib><creatorcontrib>Vila-Pueyo, Marta</creatorcontrib><creatorcontrib>Pozo-Rosich, Patricia</creatorcontrib><title>The impact of epigenetic mechanisms in migraine: Current knowledge and future directions</title><title>Cephalalgia</title><addtitle>Cephalalgia</addtitle><description>Background
Epigenetic mechanisms, including DNA methylation, microRNAs and histone modifications, may modulate the genetic expression in migraine and its interaction with internal and external factors, such as lifestyle and environmental changes.
Objective
To summarize, contextualize and critically analyze the published literature on the current state of epigenetic mechanisms in migraine in a narrative review.
Findings
The studies published to date have used different approaches and methodologies to determine the role of epigenetic mechanisms in migraine. Epigenetic changes seem to be involved in migraine and are increasing our knowledge of the disease.
Conclusions
Changes in DNA methylation, microRNA expression and histone modifications could be utilized as biomarkers that would be highly valuable for patient stratification, molecular diagnosis, and precision medicine in migraine.</description><subject>DNA Methylation</subject><subject>Epigenesis, Genetic</subject><subject>Gene Expression</subject><subject>Humans</subject><subject>MicroRNAs - genetics</subject><subject>Migraine Disorders - genetics</subject><issn>0333-1024</issn><issn>1468-2982</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><sourceid>EIF</sourceid><recordid>eNp9kE1PwzAMhiMEYmPwA7igHLl05KNpFm5o4kuaxGVI3Ko0dbqMNi1JK8S_p9MGFyQutmU_fmW_CF1SMqdUyhvCOaeEpYxRmgpFsyM0pWm2SJhasGM03c2THTBBZzFuCSEiI9kpmvBMCsWImqK39QawazptetxaDJ2rwEPvDG7AbLR3sYnYedy4Kmjn4RYvhxDA9_jdt581lBVg7Utsh34IgEsXwPSu9fEcnVhdR7g45Bl6fbhfL5-S1cvj8_JulRi-4H2iQPGxADtephfAgGoqDSFWZbaQY0cRJtIxirSQwjCmMiis5GBEwSkFPkPXe90utB8DxD5vXDRQ19pDO8ScSSkylkpGRpTuURPaGAPYvAuu0eErpyTfGZr_MXTcuTrID0UD5e_Gj4MjMN8DUVeQb9sh-PHdfxS_AcfPfWc</recordid><startdate>202302</startdate><enddate>202302</enddate><creator>Gallardo, Víctor José</creator><creator>Vila-Pueyo, Marta</creator><creator>Pozo-Rosich, Patricia</creator><general>SAGE Publications</general><scope>AFRWT</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0652-2988</orcidid><orcidid>https://orcid.org/0000-0002-3042-2007</orcidid><orcidid>https://orcid.org/0000-0003-0796-4702</orcidid></search><sort><creationdate>202302</creationdate><title>The impact of epigenetic mechanisms in migraine: Current knowledge and future directions</title><author>Gallardo, Víctor José ; Vila-Pueyo, Marta ; Pozo-Rosich, Patricia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c383t-9e93383ef560a8e2e1a17c00f96fb7a8e90254e9054b75c2296ebf73ec5b311e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>DNA Methylation</topic><topic>Epigenesis, Genetic</topic><topic>Gene Expression</topic><topic>Humans</topic><topic>MicroRNAs - genetics</topic><topic>Migraine Disorders - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gallardo, Víctor José</creatorcontrib><creatorcontrib>Vila-Pueyo, Marta</creatorcontrib><creatorcontrib>Pozo-Rosich, Patricia</creatorcontrib><collection>Sage Journals GOLD Open Access 2024</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cephalalgia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gallardo, Víctor José</au><au>Vila-Pueyo, Marta</au><au>Pozo-Rosich, Patricia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The impact of epigenetic mechanisms in migraine: Current knowledge and future directions</atitle><jtitle>Cephalalgia</jtitle><addtitle>Cephalalgia</addtitle><date>2023-02</date><risdate>2023</risdate><volume>43</volume><issue>2</issue><spage>3331024221145916</spage><epage>3331024221145916</epage><pages>3331024221145916-3331024221145916</pages><issn>0333-1024</issn><eissn>1468-2982</eissn><abstract>Background
Epigenetic mechanisms, including DNA methylation, microRNAs and histone modifications, may modulate the genetic expression in migraine and its interaction with internal and external factors, such as lifestyle and environmental changes.
Objective
To summarize, contextualize and critically analyze the published literature on the current state of epigenetic mechanisms in migraine in a narrative review.
Findings
The studies published to date have used different approaches and methodologies to determine the role of epigenetic mechanisms in migraine. Epigenetic changes seem to be involved in migraine and are increasing our knowledge of the disease.
Conclusions
Changes in DNA methylation, microRNA expression and histone modifications could be utilized as biomarkers that would be highly valuable for patient stratification, molecular diagnosis, and precision medicine in migraine.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>36759209</pmid><doi>10.1177/03331024221145916</doi><orcidid>https://orcid.org/0000-0003-0652-2988</orcidid><orcidid>https://orcid.org/0000-0002-3042-2007</orcidid><orcidid>https://orcid.org/0000-0003-0796-4702</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0333-1024 |
| ispartof | Cephalalgia, 2023-02, Vol.43 (2), p.3331024221145916-3331024221145916 |
| issn | 0333-1024 1468-2982 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2775624720 |
| source | MEDLINE; Sage Journals GOLD Open Access 2024; Alma/SFX Local Collection |
| subjects | DNA Methylation Epigenesis, Genetic Gene Expression Humans MicroRNAs - genetics Migraine Disorders - genetics |
| title | The impact of epigenetic mechanisms in migraine: Current knowledge and future directions |
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