Candida albicans causes brain regional invasion and necrosis, and activation of microglia during lethal neonatal neurocandidiasis

Neurocandidiasis is a fungal infection that primarily affects neonates, which is associated with 70% case fatality rates, while pediatric patients who survive infection often have long-term neurological sequelae, making it a clinical requirement to understand the pathogenesis of neonatal neurocandid...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Microbes and infection 2023-07, Vol.25 (6), p.105119-105119, Article 105119
Hauptverfasser: Flores-Maldonado, Orlando, González, Gloria M., Enríquez-Bañuelos, Juan F., Andrade, Ángel, Treviño-Rangel, Rogelio, Becerril-García, Miguel A.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 105119
container_issue 6
container_start_page 105119
container_title Microbes and infection
container_volume 25
creator Flores-Maldonado, Orlando
González, Gloria M.
Enríquez-Bañuelos, Juan F.
Andrade, Ángel
Treviño-Rangel, Rogelio
Becerril-García, Miguel A.
description Neurocandidiasis is a fungal infection that primarily affects neonates, which is associated with 70% case fatality rates, while pediatric patients who survive infection often have long-term neurological sequelae, making it a clinical requirement to understand the pathogenesis of neonatal neurocandidiasis. Currently, the brain regions to Candida albicans invasion during the neonatal period are not characterized. In this study, 0-day-old mice were infected with C. albicans intravenously to determine dissemination and invasion into the brain at different times post-infection by fungal burden assay and histopathological analysis, additionally cellular death and microglial activation were evaluated by flow cytometry. The results evidenced the dissemination of C. albicans within the first hour of infection in the brain. The meninges were the initial site of invasion during the first 6 hours post infection and then filamentous structures into the brain parenchyma increases during infection, the anatomic regions most susceptible to invasion being the cerebral cortex, thalamus, hypothalamus, midbrain, pons, and medulla oblongata. Furthermore, C. albicans invasion of brain tissue results in cell necrosis and activation of microglia as a consequence of fungal invasion.
doi_str_mv 10.1016/j.micinf.2023.105119
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2775624568</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1286457923000229</els_id><sourcerecordid>2775624568</sourcerecordid><originalsourceid>FETCH-LOGICAL-c311t-65bb13b39b4d4cca956dbc354009c1d774264a29ae75f67d0d18bfc43dbddf933</originalsourceid><addsrcrecordid>eNp9UMtOHDEQtKKgQEj-IIp8zIFZ7PFrfIkUrYBEQuICEjfLr9n0atZD7JmVOPLneHdIjjl1tV1d1V0IfaFkRQmVl9vVDjykftWSltUnQal-h86okrpRlD--r7jtZMOF0qfoYylbQqhQkn9Ap0wq0XWanKGXtU0BgsV2cOBtKtjbucSCXbaQcI4bGJMdMKS9LRXiSscp-jwWKBfHzvoJ9nY6fI49rkvlcTOAxWHOkDZ4iNPvKpBi1ZmOYM6jP7pClSyf0ElvhxI_v9Vz9HB9db_-2dze3fxa_7htPKN0aqRwjjLHtOOBe2-1kMF5Jjgh2tOgFG8lt622UYleqkAC7VzvOQsuhF4zdo6-LbpPefwzxzKZHRQfh8HW1eZiWqWEbLmQXaXyhXo4s-TYm6cMO5ufDSXmEL7ZmiV8cwjfLOHXsa9vDrPbxfBv6G_alfB9IcR65x5iNsVDTD4GyNFPJozwf4dXz5yamw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2775624568</pqid></control><display><type>article</type><title>Candida albicans causes brain regional invasion and necrosis, and activation of microglia during lethal neonatal neurocandidiasis</title><source>Access via ScienceDirect (Elsevier)</source><creator>Flores-Maldonado, Orlando ; González, Gloria M. ; Enríquez-Bañuelos, Juan F. ; Andrade, Ángel ; Treviño-Rangel, Rogelio ; Becerril-García, Miguel A.</creator><creatorcontrib>Flores-Maldonado, Orlando ; González, Gloria M. ; Enríquez-Bañuelos, Juan F. ; Andrade, Ángel ; Treviño-Rangel, Rogelio ; Becerril-García, Miguel A.</creatorcontrib><description>Neurocandidiasis is a fungal infection that primarily affects neonates, which is associated with 70% case fatality rates, while pediatric patients who survive infection often have long-term neurological sequelae, making it a clinical requirement to understand the pathogenesis of neonatal neurocandidiasis. Currently, the brain regions to Candida albicans invasion during the neonatal period are not characterized. In this study, 0-day-old mice were infected with C. albicans intravenously to determine dissemination and invasion into the brain at different times post-infection by fungal burden assay and histopathological analysis, additionally cellular death and microglial activation were evaluated by flow cytometry. The results evidenced the dissemination of C. albicans within the first hour of infection in the brain. The meninges were the initial site of invasion during the first 6 hours post infection and then filamentous structures into the brain parenchyma increases during infection, the anatomic regions most susceptible to invasion being the cerebral cortex, thalamus, hypothalamus, midbrain, pons, and medulla oblongata. Furthermore, C. albicans invasion of brain tissue results in cell necrosis and activation of microglia as a consequence of fungal invasion.</description><identifier>ISSN: 1286-4579</identifier><identifier>EISSN: 1769-714X</identifier><identifier>DOI: 10.1016/j.micinf.2023.105119</identifier><identifier>PMID: 36758890</identifier><language>eng</language><publisher>France: Elsevier Masson SAS</publisher><subject>Apoptosis ; Candida albicans ; Candidemia ; Microglia activation ; Necrosis ; Neurocandidiasis ; Newborn</subject><ispartof>Microbes and infection, 2023-07, Vol.25 (6), p.105119-105119, Article 105119</ispartof><rights>2023 Institut Pasteur</rights><rights>Copyright © 2023 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c311t-65bb13b39b4d4cca956dbc354009c1d774264a29ae75f67d0d18bfc43dbddf933</cites><orcidid>0000-0002-4433-6556 ; 0000-0003-1329-7918</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.micinf.2023.105119$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36758890$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Flores-Maldonado, Orlando</creatorcontrib><creatorcontrib>González, Gloria M.</creatorcontrib><creatorcontrib>Enríquez-Bañuelos, Juan F.</creatorcontrib><creatorcontrib>Andrade, Ángel</creatorcontrib><creatorcontrib>Treviño-Rangel, Rogelio</creatorcontrib><creatorcontrib>Becerril-García, Miguel A.</creatorcontrib><title>Candida albicans causes brain regional invasion and necrosis, and activation of microglia during lethal neonatal neurocandidiasis</title><title>Microbes and infection</title><addtitle>Microbes Infect</addtitle><description>Neurocandidiasis is a fungal infection that primarily affects neonates, which is associated with 70% case fatality rates, while pediatric patients who survive infection often have long-term neurological sequelae, making it a clinical requirement to understand the pathogenesis of neonatal neurocandidiasis. Currently, the brain regions to Candida albicans invasion during the neonatal period are not characterized. In this study, 0-day-old mice were infected with C. albicans intravenously to determine dissemination and invasion into the brain at different times post-infection by fungal burden assay and histopathological analysis, additionally cellular death and microglial activation were evaluated by flow cytometry. The results evidenced the dissemination of C. albicans within the first hour of infection in the brain. The meninges were the initial site of invasion during the first 6 hours post infection and then filamentous structures into the brain parenchyma increases during infection, the anatomic regions most susceptible to invasion being the cerebral cortex, thalamus, hypothalamus, midbrain, pons, and medulla oblongata. Furthermore, C. albicans invasion of brain tissue results in cell necrosis and activation of microglia as a consequence of fungal invasion.</description><subject>Apoptosis</subject><subject>Candida albicans</subject><subject>Candidemia</subject><subject>Microglia activation</subject><subject>Necrosis</subject><subject>Neurocandidiasis</subject><subject>Newborn</subject><issn>1286-4579</issn><issn>1769-714X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9UMtOHDEQtKKgQEj-IIp8zIFZ7PFrfIkUrYBEQuICEjfLr9n0atZD7JmVOPLneHdIjjl1tV1d1V0IfaFkRQmVl9vVDjykftWSltUnQal-h86okrpRlD--r7jtZMOF0qfoYylbQqhQkn9Ap0wq0XWanKGXtU0BgsV2cOBtKtjbucSCXbaQcI4bGJMdMKS9LRXiSscp-jwWKBfHzvoJ9nY6fI49rkvlcTOAxWHOkDZ4iNPvKpBi1ZmOYM6jP7pClSyf0ElvhxI_v9Vz9HB9db_-2dze3fxa_7htPKN0aqRwjjLHtOOBe2-1kMF5Jjgh2tOgFG8lt622UYleqkAC7VzvOQsuhF4zdo6-LbpPefwzxzKZHRQfh8HW1eZiWqWEbLmQXaXyhXo4s-TYm6cMO5ufDSXmEL7ZmiV8cwjfLOHXsa9vDrPbxfBv6G_alfB9IcR65x5iNsVDTD4GyNFPJozwf4dXz5yamw</recordid><startdate>202307</startdate><enddate>202307</enddate><creator>Flores-Maldonado, Orlando</creator><creator>González, Gloria M.</creator><creator>Enríquez-Bañuelos, Juan F.</creator><creator>Andrade, Ángel</creator><creator>Treviño-Rangel, Rogelio</creator><creator>Becerril-García, Miguel A.</creator><general>Elsevier Masson SAS</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4433-6556</orcidid><orcidid>https://orcid.org/0000-0003-1329-7918</orcidid></search><sort><creationdate>202307</creationdate><title>Candida albicans causes brain regional invasion and necrosis, and activation of microglia during lethal neonatal neurocandidiasis</title><author>Flores-Maldonado, Orlando ; González, Gloria M. ; Enríquez-Bañuelos, Juan F. ; Andrade, Ángel ; Treviño-Rangel, Rogelio ; Becerril-García, Miguel A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-65bb13b39b4d4cca956dbc354009c1d774264a29ae75f67d0d18bfc43dbddf933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Apoptosis</topic><topic>Candida albicans</topic><topic>Candidemia</topic><topic>Microglia activation</topic><topic>Necrosis</topic><topic>Neurocandidiasis</topic><topic>Newborn</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Flores-Maldonado, Orlando</creatorcontrib><creatorcontrib>González, Gloria M.</creatorcontrib><creatorcontrib>Enríquez-Bañuelos, Juan F.</creatorcontrib><creatorcontrib>Andrade, Ángel</creatorcontrib><creatorcontrib>Treviño-Rangel, Rogelio</creatorcontrib><creatorcontrib>Becerril-García, Miguel A.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Microbes and infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Flores-Maldonado, Orlando</au><au>González, Gloria M.</au><au>Enríquez-Bañuelos, Juan F.</au><au>Andrade, Ángel</au><au>Treviño-Rangel, Rogelio</au><au>Becerril-García, Miguel A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Candida albicans causes brain regional invasion and necrosis, and activation of microglia during lethal neonatal neurocandidiasis</atitle><jtitle>Microbes and infection</jtitle><addtitle>Microbes Infect</addtitle><date>2023-07</date><risdate>2023</risdate><volume>25</volume><issue>6</issue><spage>105119</spage><epage>105119</epage><pages>105119-105119</pages><artnum>105119</artnum><issn>1286-4579</issn><eissn>1769-714X</eissn><abstract>Neurocandidiasis is a fungal infection that primarily affects neonates, which is associated with 70% case fatality rates, while pediatric patients who survive infection often have long-term neurological sequelae, making it a clinical requirement to understand the pathogenesis of neonatal neurocandidiasis. Currently, the brain regions to Candida albicans invasion during the neonatal period are not characterized. In this study, 0-day-old mice were infected with C. albicans intravenously to determine dissemination and invasion into the brain at different times post-infection by fungal burden assay and histopathological analysis, additionally cellular death and microglial activation were evaluated by flow cytometry. The results evidenced the dissemination of C. albicans within the first hour of infection in the brain. The meninges were the initial site of invasion during the first 6 hours post infection and then filamentous structures into the brain parenchyma increases during infection, the anatomic regions most susceptible to invasion being the cerebral cortex, thalamus, hypothalamus, midbrain, pons, and medulla oblongata. Furthermore, C. albicans invasion of brain tissue results in cell necrosis and activation of microglia as a consequence of fungal invasion.</abstract><cop>France</cop><pub>Elsevier Masson SAS</pub><pmid>36758890</pmid><doi>10.1016/j.micinf.2023.105119</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-4433-6556</orcidid><orcidid>https://orcid.org/0000-0003-1329-7918</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 1286-4579
ispartof Microbes and infection, 2023-07, Vol.25 (6), p.105119-105119, Article 105119
issn 1286-4579
1769-714X
language eng
recordid cdi_proquest_miscellaneous_2775624568
source Access via ScienceDirect (Elsevier)
subjects Apoptosis
Candida albicans
Candidemia
Microglia activation
Necrosis
Neurocandidiasis
Newborn
title Candida albicans causes brain regional invasion and necrosis, and activation of microglia during lethal neonatal neurocandidiasis
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T22%3A19%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Candida%20albicans%20causes%20brain%20regional%20invasion%20and%20necrosis,%20and%20activation%20of%20microglia%20during%20lethal%20neonatal%20neurocandidiasis&rft.jtitle=Microbes%20and%20infection&rft.au=Flores-Maldonado,%20Orlando&rft.date=2023-07&rft.volume=25&rft.issue=6&rft.spage=105119&rft.epage=105119&rft.pages=105119-105119&rft.artnum=105119&rft.issn=1286-4579&rft.eissn=1769-714X&rft_id=info:doi/10.1016/j.micinf.2023.105119&rft_dat=%3Cproquest_cross%3E2775624568%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2775624568&rft_id=info:pmid/36758890&rft_els_id=S1286457923000229&rfr_iscdi=true