Noninvasive evaluation of PD-L1 expression in non-small cell lung cancer by immunoPET imaging using an acylating agent–modified antibody fragment

Purpose The aim of this study was to explore an effective 124 I labeling strategy and improve the signal-to-noise ratio when evaluating the expression of PD-L1 using an 124 I-iodinated durvalumab (durva) F(ab') 2 fragment. Methods The prepared durva F(ab') 2 fragments were incubated with N...

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Veröffentlicht in:	European journal of nuclear medicine and molecular imaging 2023-05, Vol.50 (6), p.1585-1596
Hauptverfasser:	Cheng, Yuan, Shi, Dai, Ye, Renjie, Fu, Wenhui, Ma, Pengcheng, Si, Zhan, Xu, Zhan, Li, Lixin, Lin, Qingyu, Cheng, Dengfeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Antibodies B7-H1 Antigen - metabolism Biodistribution Carcinoma, Non-Small-Cell Lung Cardiology Conjugation Humans Imaging Immunoglobulin Fab Fragments - metabolism Labelling Lung cancer Lung Neoplasms - diagnostic imaging Medicine Medicine & Public Health Non-small cell lung carcinoma Noninvasive evaluation Nuclear Medicine Oncology Original Article Orthopedics PD-L1 protein Pharmacokinetics Positron emission Preclinical Imaging Purity Radiochemistry Radiology Radiopharmaceuticals Signal to noise ratio Small cell lung carcinoma Stability Tissue Distribution
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