Phosphoproteomics Profiling Defines a Target Landscape of the Basophilic Protein Kinases AKT, S6K, and RSK in Skeletal Myotubes

Phosphorylation-dependent signal transduction plays an important role in regulating the functions and fate of skeletal muscle cells. Central players in the phospho-signaling network are the protein kinases AKT, S6K, and RSK as part of the PI3K-AKT-mTOR-S6K and RAF-MEK-ERK-RSK pathways. However, desp...

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Veröffentlicht in:	Journal of proteome research 2023-03, Vol.22 (3), p.768-789
Hauptverfasser:	Fricke, Anna L., Mühlhäuser, Wignand W. D., Reimann, Lena, Zimmermann, Johannes P., Reichenbach, Christa, Knapp, Bettina, Peikert, Christian D., Heberle, Alexander M., Faessler, Erik, Schäuble, Sascha, Hahn, Udo, Thedieck, Kathrin, Radziwill, Gerald, Warscheid, Bettina
Format:	Artikel
Sprache:	eng
Schlagworte:	Muscle Fibers, Skeletal - metabolism Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Ribosomal Protein S6 Kinases, 70-kDa Ribosomal Protein S6 Kinases, 90-kDa Signal Transduction - physiology
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