Inhibiting mitochondrial inflammation through Drp1/HK1/NLRP3 pathway: A mechanism of alpinetin attenuated aging‐associated cognitive impairment

Mitochondrial inflammation triggered by abnormal mitochondrial division and regulated by the Drp1/HK1/NLRP3 pathway is correlated with the progression of aging‐associated cognitive impairment (AACI). Alpinetin is a novel flavonoid derived from Zingiberaceae that has many bioactivities such as antiin...

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Veröffentlicht in:	Phytotherapy research 2023-06, Vol.37 (6), p.2454-2471
Hauptverfasser:	Chen, Yuanyuan, Yang, Chuan, Zou, Mi, Wang, Dan, Sheng, Ruilin, Zhan, Meng, Chen, Qi, Yang, Wenqin, Liu, Xiao, Xu, Shijun
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging (artificial) aging‐associated cognitive impairment alpinetin Animals Attenuation Caspase-1 Cognitive ability Cognitive Dysfunction - drug therapy Drp1/HK1/NLRP3 pathway Flavonoids Galactose Galactose - adverse effects Impairment Inflammation Inflammation - drug therapy Mice Mitochondria mitochondrial inflammation Neuroprotection NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Oxidation
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