High-risk mucosal human papillomavirus-associated squamous cell carcinoma of the fingers presents distinctive clinicopathological characteristics and outcomes: a bicentric retrospective study
High-risk mucosal human papillomavirus (HR-HPV) seems to play a role in cutaneous squamous cell carcinoma (cSCC), particularly in nail tumours, where genitodigital transmission has been suggested. The role of HR-HPV in nonungual cSCC of the finger needs to be clarified. To evaluate the prevalence, c...
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Veröffentlicht in: | Clinical and experimental dermatology 2023-03, Vol.48 (3), p.211-217 |
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creator | Marti-Marti, Ignasi Bosch-Amate, Xavier Morgado-Carrasco, Daniel Albero-González, Raquel Santos-Briz, Angel Puebla-Tornero, Laura Revelles-Peñas, Leonor Cañueto, Javier Alòs, Llúcia Toll, Agustí |
description | High-risk mucosal human papillomavirus (HR-HPV) seems to play a role in cutaneous squamous cell carcinoma (cSCC), particularly in nail tumours, where genitodigital transmission has been suggested. The role of HR-HPV in nonungual cSCC of the finger needs to be clarified.
To evaluate the prevalence, clinicopathological characteristics, surrogates and outcomes of HR-HPV in cSCC of the finger.
This was an observational bicentric study including patients with an excised in situ or invasive cSCC located on the finger. Differences in HR-HPV and non-HR-HPV tumours were evaluated.
Forty-five patients (45 tumours) were included. HR-HPV was detected in 33% of cases (22% HPV type 16). The mean age was lower in patients with HR-HPV than in those with non-HR-HPV (62·4 vs. 81·1 years, P = 0·001). HR-HPV tumours were smaller (10 mm vs. 15 mm, P = 0·07) and more frequently intraepidermal (60% vs. 20%, P = 0·004). The absence of elastosis (P = 0·030) and inflammation (P = 0·026) and the presence of basaloid morphology (P = 0·003) were surrogates of HR-HPV detection. Mean p16 positivity was 61% in HR-HPV and 36% in non-HR-HPV tumours (P = 0·061). Recurrence after surgery was more common in HR-HPV tumours (58% vs. 34%), although this was not statistically significant. HR-HPV was detected in 27% of the nonungual tumours.
HR-HPV-associated cSCC of the finger appears in younger patients, is smaller and is less infiltrative than non-HR-HPV tumours. The presence of a basaloid morphology and the absence of elastosis and inflammation could be used as markers for HR-HPV detection. The high prevalence of HR-HPV in nonungual cSCC suggests its aetiopathogenic role in these tumours. |
doi_str_mv | 10.1093/ced/llac086 |
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To evaluate the prevalence, clinicopathological characteristics, surrogates and outcomes of HR-HPV in cSCC of the finger.
This was an observational bicentric study including patients with an excised in situ or invasive cSCC located on the finger. Differences in HR-HPV and non-HR-HPV tumours were evaluated.
Forty-five patients (45 tumours) were included. HR-HPV was detected in 33% of cases (22% HPV type 16). The mean age was lower in patients with HR-HPV than in those with non-HR-HPV (62·4 vs. 81·1 years, P = 0·001). HR-HPV tumours were smaller (10 mm vs. 15 mm, P = 0·07) and more frequently intraepidermal (60% vs. 20%, P = 0·004). The absence of elastosis (P = 0·030) and inflammation (P = 0·026) and the presence of basaloid morphology (P = 0·003) were surrogates of HR-HPV detection. Mean p16 positivity was 61% in HR-HPV and 36% in non-HR-HPV tumours (P = 0·061). Recurrence after surgery was more common in HR-HPV tumours (58% vs. 34%), although this was not statistically significant. HR-HPV was detected in 27% of the nonungual tumours.
HR-HPV-associated cSCC of the finger appears in younger patients, is smaller and is less infiltrative than non-HR-HPV tumours. The presence of a basaloid morphology and the absence of elastosis and inflammation could be used as markers for HR-HPV detection. The high prevalence of HR-HPV in nonungual cSCC suggests its aetiopathogenic role in these tumours.</description><identifier>ISSN: 0307-6938</identifier><identifier>EISSN: 1365-2230</identifier><identifier>DOI: 10.1093/ced/llac086</identifier><identifier>PMID: 36763739</identifier><language>eng</language><publisher>England</publisher><subject>Carcinoma, Squamous Cell - pathology ; Human Papillomavirus Viruses ; Humans ; Inflammation ; Papillomaviridae ; Papillomavirus Infections ; Retrospective Studies ; Skin Neoplasms</subject><ispartof>Clinical and experimental dermatology, 2023-03, Vol.48 (3), p.211-217</ispartof><rights>The Author(s) 2022. Published by Oxford University Press on behalf of British Association of Dermatologists. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c289t-9da19d737b34a68f2abf2936cf9798270c63cfb146c8627b559063f5f2baee0d3</citedby><cites>FETCH-LOGICAL-c289t-9da19d737b34a68f2abf2936cf9798270c63cfb146c8627b559063f5f2baee0d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36763739$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marti-Marti, Ignasi</creatorcontrib><creatorcontrib>Bosch-Amate, Xavier</creatorcontrib><creatorcontrib>Morgado-Carrasco, Daniel</creatorcontrib><creatorcontrib>Albero-González, Raquel</creatorcontrib><creatorcontrib>Santos-Briz, Angel</creatorcontrib><creatorcontrib>Puebla-Tornero, Laura</creatorcontrib><creatorcontrib>Revelles-Peñas, Leonor</creatorcontrib><creatorcontrib>Cañueto, Javier</creatorcontrib><creatorcontrib>Alòs, Llúcia</creatorcontrib><creatorcontrib>Toll, Agustí</creatorcontrib><title>High-risk mucosal human papillomavirus-associated squamous cell carcinoma of the fingers presents distinctive clinicopathological characteristics and outcomes: a bicentric retrospective study</title><title>Clinical and experimental dermatology</title><addtitle>Clin Exp Dermatol</addtitle><description>High-risk mucosal human papillomavirus (HR-HPV) seems to play a role in cutaneous squamous cell carcinoma (cSCC), particularly in nail tumours, where genitodigital transmission has been suggested. The role of HR-HPV in nonungual cSCC of the finger needs to be clarified.
To evaluate the prevalence, clinicopathological characteristics, surrogates and outcomes of HR-HPV in cSCC of the finger.
This was an observational bicentric study including patients with an excised in situ or invasive cSCC located on the finger. Differences in HR-HPV and non-HR-HPV tumours were evaluated.
Forty-five patients (45 tumours) were included. HR-HPV was detected in 33% of cases (22% HPV type 16). The mean age was lower in patients with HR-HPV than in those with non-HR-HPV (62·4 vs. 81·1 years, P = 0·001). HR-HPV tumours were smaller (10 mm vs. 15 mm, P = 0·07) and more frequently intraepidermal (60% vs. 20%, P = 0·004). The absence of elastosis (P = 0·030) and inflammation (P = 0·026) and the presence of basaloid morphology (P = 0·003) were surrogates of HR-HPV detection. Mean p16 positivity was 61% in HR-HPV and 36% in non-HR-HPV tumours (P = 0·061). Recurrence after surgery was more common in HR-HPV tumours (58% vs. 34%), although this was not statistically significant. HR-HPV was detected in 27% of the nonungual tumours.
HR-HPV-associated cSCC of the finger appears in younger patients, is smaller and is less infiltrative than non-HR-HPV tumours. The presence of a basaloid morphology and the absence of elastosis and inflammation could be used as markers for HR-HPV detection. The high prevalence of HR-HPV in nonungual cSCC suggests its aetiopathogenic role in these tumours.</description><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Human Papillomavirus Viruses</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Papillomaviridae</subject><subject>Papillomavirus Infections</subject><subject>Retrospective Studies</subject><subject>Skin Neoplasms</subject><issn>0307-6938</issn><issn>1365-2230</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kcFu1DAQhi0EokvhxB35iITSOvbGjrmhqtBKlbjAOZpM7I3BiVOPU6lPx6uR1W5PI40-fTP6f8Y-1uKqFlZdoxuuYwQUrX7FdrXSTSWlEq_ZTihhKm1Ve8HeEf0Rola1ad6yC6WNVkbZHft3Fw5jlQP95dOKiSDycZ1g5gssIcY0wVPIK1VAlDBAcQOnxxWmtBJHFyNHyBjmjePJ8zI67sN8cJn4kh25uRAfApUwYwlPjmMMc8C0QBlTTIeA2z0cIQMWl48cEod54GktmCZHXznwPuDmyQF5diUnWtzJRWUdnt-zNx4iuQ_necl-f7_9dXNXPfz8cX_z7aFC2dpS2QFqOxhlerUH3XoJvZdWafTW2FYagVqh7-u9xlZL0zeNFVr5xssenBODumSfT94lp8fVUemmQMcAYHZbFp00ptFS7rXa0C8nFLdnKTvfLTlMkJ-7WnTHxrqtse7c2EZ_OovXftr2L-xLReo__MOaNg</recordid><startdate>20230301</startdate><enddate>20230301</enddate><creator>Marti-Marti, Ignasi</creator><creator>Bosch-Amate, Xavier</creator><creator>Morgado-Carrasco, Daniel</creator><creator>Albero-González, Raquel</creator><creator>Santos-Briz, Angel</creator><creator>Puebla-Tornero, Laura</creator><creator>Revelles-Peñas, Leonor</creator><creator>Cañueto, Javier</creator><creator>Alòs, Llúcia</creator><creator>Toll, Agustí</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20230301</creationdate><title>High-risk mucosal human papillomavirus-associated squamous cell carcinoma of the fingers presents distinctive clinicopathological characteristics and outcomes: a bicentric retrospective study</title><author>Marti-Marti, Ignasi ; Bosch-Amate, Xavier ; Morgado-Carrasco, Daniel ; Albero-González, Raquel ; Santos-Briz, Angel ; Puebla-Tornero, Laura ; Revelles-Peñas, Leonor ; Cañueto, Javier ; Alòs, Llúcia ; Toll, Agustí</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c289t-9da19d737b34a68f2abf2936cf9798270c63cfb146c8627b559063f5f2baee0d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Human Papillomavirus Viruses</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Papillomaviridae</topic><topic>Papillomavirus Infections</topic><topic>Retrospective Studies</topic><topic>Skin Neoplasms</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marti-Marti, Ignasi</creatorcontrib><creatorcontrib>Bosch-Amate, Xavier</creatorcontrib><creatorcontrib>Morgado-Carrasco, Daniel</creatorcontrib><creatorcontrib>Albero-González, Raquel</creatorcontrib><creatorcontrib>Santos-Briz, Angel</creatorcontrib><creatorcontrib>Puebla-Tornero, Laura</creatorcontrib><creatorcontrib>Revelles-Peñas, Leonor</creatorcontrib><creatorcontrib>Cañueto, Javier</creatorcontrib><creatorcontrib>Alòs, Llúcia</creatorcontrib><creatorcontrib>Toll, Agustí</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marti-Marti, Ignasi</au><au>Bosch-Amate, Xavier</au><au>Morgado-Carrasco, Daniel</au><au>Albero-González, Raquel</au><au>Santos-Briz, Angel</au><au>Puebla-Tornero, Laura</au><au>Revelles-Peñas, Leonor</au><au>Cañueto, Javier</au><au>Alòs, Llúcia</au><au>Toll, Agustí</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High-risk mucosal human papillomavirus-associated squamous cell carcinoma of the fingers presents distinctive clinicopathological characteristics and outcomes: a bicentric retrospective study</atitle><jtitle>Clinical and experimental dermatology</jtitle><addtitle>Clin Exp Dermatol</addtitle><date>2023-03-01</date><risdate>2023</risdate><volume>48</volume><issue>3</issue><spage>211</spage><epage>217</epage><pages>211-217</pages><issn>0307-6938</issn><eissn>1365-2230</eissn><abstract>High-risk mucosal human papillomavirus (HR-HPV) seems to play a role in cutaneous squamous cell carcinoma (cSCC), particularly in nail tumours, where genitodigital transmission has been suggested. The role of HR-HPV in nonungual cSCC of the finger needs to be clarified.
To evaluate the prevalence, clinicopathological characteristics, surrogates and outcomes of HR-HPV in cSCC of the finger.
This was an observational bicentric study including patients with an excised in situ or invasive cSCC located on the finger. Differences in HR-HPV and non-HR-HPV tumours were evaluated.
Forty-five patients (45 tumours) were included. HR-HPV was detected in 33% of cases (22% HPV type 16). The mean age was lower in patients with HR-HPV than in those with non-HR-HPV (62·4 vs. 81·1 years, P = 0·001). HR-HPV tumours were smaller (10 mm vs. 15 mm, P = 0·07) and more frequently intraepidermal (60% vs. 20%, P = 0·004). The absence of elastosis (P = 0·030) and inflammation (P = 0·026) and the presence of basaloid morphology (P = 0·003) were surrogates of HR-HPV detection. Mean p16 positivity was 61% in HR-HPV and 36% in non-HR-HPV tumours (P = 0·061). Recurrence after surgery was more common in HR-HPV tumours (58% vs. 34%), although this was not statistically significant. HR-HPV was detected in 27% of the nonungual tumours.
HR-HPV-associated cSCC of the finger appears in younger patients, is smaller and is less infiltrative than non-HR-HPV tumours. The presence of a basaloid morphology and the absence of elastosis and inflammation could be used as markers for HR-HPV detection. The high prevalence of HR-HPV in nonungual cSCC suggests its aetiopathogenic role in these tumours.</abstract><cop>England</cop><pmid>36763739</pmid><doi>10.1093/ced/llac086</doi><tpages>7</tpages></addata></record> |
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subjects | Carcinoma, Squamous Cell - pathology Human Papillomavirus Viruses Humans Inflammation Papillomaviridae Papillomavirus Infections Retrospective Studies Skin Neoplasms |
title | High-risk mucosal human papillomavirus-associated squamous cell carcinoma of the fingers presents distinctive clinicopathological characteristics and outcomes: a bicentric retrospective study |
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