Disentangling the common genetic architecture and causality of rheumatoid arthritis and systemic lupus erythematosus with COVID‐19 outcomes: Genome‐wide cross trait analysis and bidirectional Mendelian randomization study

Coronavirus Disease (COVID‐19) may cause a dysregulation of the immune system and has complex relationships with multiple autoimmune diseases, including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). However, little is known about their common genetic architecture. Using the lates...

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Veröffentlicht in:	Journal of medical virology 2023-02, Vol.95 (2), p.e28570-n/a
Hauptverfasser:	Yao, Minhao, Huang, Xin, Guo, Yunshan, Zhao, Jie V., Liu, Zhonghua
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Arthritis Arthritis, Rheumatoid Autoimmune diseases Chronic conditions Coagulation Consortia Coronaviruses COVID-19 COVID-19 - complications cross‐trait Etiology Genetic analysis Genetics Genome-Wide Association Study Genomes GWAS Hospitalization Humans Immune response Immune system Liability Localization Lupus Lupus Erythematosus, Systemic Mendelian randomization Mendelian Randomization Analysis Polymorphism, Single Nucleotide Randomization Rheumatoid arthritis SARS-CoV-2 - genetics Severe acute respiratory syndrome coronavirus 2 shared genetics Systemic lupus erythematosus Tyk2 protein Viral diseases Virology
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