Lactate oxidase/vSIRPα conjugates efficiently consume tumor-produced lactates and locally produce tumor-necrotic H2O2 to suppress tumor growth

Aggressive tumor formation often leads to excessive anaerobic glycolysis and massive production and accumulation of lactate in the tumor microenvironment (TME). To significantly curb lactate accumulation in TME, in this study, lactate oxidase (LOX) was used as a potential therapeutic enzyme and sign...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	International journal of biological macromolecules 2023-03, Vol.231, p.123577-123577, Article 123577
Hauptverfasser:	Kang, Yujin, Yeo, Mirae, Choi, Hyukjun, Jun, Heejin, Eom, Soomin, Park, Seong Guk, Yoon, Haejin, Kim, Eunhee, Kang, Sebyung
Format:	Artikel
Sprache:	eng
Schlagworte:	H2O2 Lactate Lactate oxidase Necrosis vSIRPα
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!