Development and implementation of a pneumatic micro-feeder for poorly-flowing solid pharmaceutical materials
[Display omitted] Consistent powder micro-feeding (
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| Veröffentlicht in: | International journal of pharmaceutics 2023-03, Vol.635, p.122691-122691, Article 122691 |
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| container_title | International journal of pharmaceutics |
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| creator | Hou, P. Besenhard, M.O. Halbert, G. Naftaly, M. Markl, D. |
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Consistent powder micro-feeding ( |
| doi_str_mv | 10.1016/j.ijpharm.2023.122691 |
| format | Article |
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Consistent powder micro-feeding (<100 g/h) is a significant challenge in manufacturing solid oral dosage forms. The low dose feeding can well control the content consistency of the dosage forms, which improves drug efficiency and reduces manufacturing waste. Current commercial micro-feeders are limited in their ability to feed < 20 g/h of cohesive (i.e. powders of poor flowability) active pharmaceutical ingredients (API) and excipients (e.g. lubricants) with low fluctuation. To breach this gap, this study presents an advanced micro-feeder design capable of feeding a range of pharmaceutical-grade powders consistently at flow rates as low as 0.7 g/h with <20 % flow rate variation. This was possible due to a novel powder conveying concept utilising particle re-entrainment to minimise flow rate variations. This work details the design of this pneumatic micro-feeder and its excellent micro-feeding performance even for cohesive powders. The experimental studies investigated the influence of the process parameters (air pressure and air flow rate) and equipment configurations (insert size and plug position) on the feeding performance of different pharmaceutical-relevant powders, i.e., microcrystalline cellulose (MCC), croscarmellose sodium (CCS), crospovidone (XPVP) and paracetamol (APAP). It was shown that the system is capable of delivering consistent powder flow rates with good repeatability and stability.</description><identifier>ISSN: 0378-5173</identifier><identifier>EISSN: 1873-3476</identifier><identifier>DOI: 10.1016/j.ijpharm.2023.122691</identifier><identifier>PMID: 36764420</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Carboxymethylcellulose Sodium ; Continuous feeding ; Excipients - chemistry ; High accuracy ; Micro-feeding ; Particle Size ; Pneumatic transferring ; Powder feeding ; Powders - chemistry ; Technology, Pharmaceutical</subject><ispartof>International journal of pharmaceutics, 2023-03, Vol.635, p.122691-122691, Article 122691</ispartof><rights>2023 The Author(s)</rights><rights>Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c360t-bfe09c3be94de22573026ecd9c23e7f182997c63f9ef7bbb537f00822c9f80a03</cites><orcidid>0000-0003-0411-733X ; 0000-0002-0671-822X ; 0000-0001-5166-8869</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijpharm.2023.122691$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>315,782,786,3554,27933,27934,46004</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36764420$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hou, P.</creatorcontrib><creatorcontrib>Besenhard, M.O.</creatorcontrib><creatorcontrib>Halbert, G.</creatorcontrib><creatorcontrib>Naftaly, M.</creatorcontrib><creatorcontrib>Markl, D.</creatorcontrib><title>Development and implementation of a pneumatic micro-feeder for poorly-flowing solid pharmaceutical materials</title><title>International journal of pharmaceutics</title><addtitle>Int J Pharm</addtitle><description>[Display omitted]
Consistent powder micro-feeding (<100 g/h) is a significant challenge in manufacturing solid oral dosage forms. The low dose feeding can well control the content consistency of the dosage forms, which improves drug efficiency and reduces manufacturing waste. Current commercial micro-feeders are limited in their ability to feed < 20 g/h of cohesive (i.e. powders of poor flowability) active pharmaceutical ingredients (API) and excipients (e.g. lubricants) with low fluctuation. To breach this gap, this study presents an advanced micro-feeder design capable of feeding a range of pharmaceutical-grade powders consistently at flow rates as low as 0.7 g/h with <20 % flow rate variation. This was possible due to a novel powder conveying concept utilising particle re-entrainment to minimise flow rate variations. This work details the design of this pneumatic micro-feeder and its excellent micro-feeding performance even for cohesive powders. The experimental studies investigated the influence of the process parameters (air pressure and air flow rate) and equipment configurations (insert size and plug position) on the feeding performance of different pharmaceutical-relevant powders, i.e., microcrystalline cellulose (MCC), croscarmellose sodium (CCS), crospovidone (XPVP) and paracetamol (APAP). It was shown that the system is capable of delivering consistent powder flow rates with good repeatability and stability.</description><subject>Carboxymethylcellulose Sodium</subject><subject>Continuous feeding</subject><subject>Excipients - chemistry</subject><subject>High accuracy</subject><subject>Micro-feeding</subject><subject>Particle Size</subject><subject>Pneumatic transferring</subject><subject>Powder feeding</subject><subject>Powders - chemistry</subject><subject>Technology, Pharmaceutical</subject><issn>0378-5173</issn><issn>1873-3476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtPwzAQhC0EgvL4CSAfuaT40djJCSHeEhIXOFuOswZXThzsBNR_j0sLV06jlWZ2dj-ETimZU0LFxXLulsO7jt2cEcbnlDFR0x00o5XkBV9IsYtmhMuqKKnkB-gwpSUhRDDK99EBF1IsFozMkL-BT_Bh6KAfse5b7LrBw3rSows9DhZrPPQwdXk2uHMmhsICtBCxDREPIUS_KqwPX65_wyl41-Kfu7SBKUe0xzkK0WmfjtGezQInWz1Cr3e3L9cPxdPz_eP11VNhuCBj0VggteEN1IsWGCslJ0yAaWvDOEhLK1bX0ghua7CyaZqSS0tIxZipbUU04UfofLN3iOFjgjSqziUD3usewpQUk7IUlFFaZWu5sea_Uopg1RBdp-NKUaLWoNVSbUGrNWi1AZ1zZ9uKqemg_Uv9ks2Gy40B8qOfDqJKxkFvoHURzKja4P6p-Aa8rZPt</recordid><startdate>20230325</startdate><enddate>20230325</enddate><creator>Hou, P.</creator><creator>Besenhard, M.O.</creator><creator>Halbert, G.</creator><creator>Naftaly, M.</creator><creator>Markl, D.</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0411-733X</orcidid><orcidid>https://orcid.org/0000-0002-0671-822X</orcidid><orcidid>https://orcid.org/0000-0001-5166-8869</orcidid></search><sort><creationdate>20230325</creationdate><title>Development and implementation of a pneumatic micro-feeder for poorly-flowing solid pharmaceutical materials</title><author>Hou, P. ; Besenhard, M.O. ; Halbert, G. ; Naftaly, M. ; Markl, D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-bfe09c3be94de22573026ecd9c23e7f182997c63f9ef7bbb537f00822c9f80a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Carboxymethylcellulose Sodium</topic><topic>Continuous feeding</topic><topic>Excipients - chemistry</topic><topic>High accuracy</topic><topic>Micro-feeding</topic><topic>Particle Size</topic><topic>Pneumatic transferring</topic><topic>Powder feeding</topic><topic>Powders - chemistry</topic><topic>Technology, Pharmaceutical</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hou, P.</creatorcontrib><creatorcontrib>Besenhard, M.O.</creatorcontrib><creatorcontrib>Halbert, G.</creatorcontrib><creatorcontrib>Naftaly, M.</creatorcontrib><creatorcontrib>Markl, D.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hou, P.</au><au>Besenhard, M.O.</au><au>Halbert, G.</au><au>Naftaly, M.</au><au>Markl, D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development and implementation of a pneumatic micro-feeder for poorly-flowing solid pharmaceutical materials</atitle><jtitle>International journal of pharmaceutics</jtitle><addtitle>Int J Pharm</addtitle><date>2023-03-25</date><risdate>2023</risdate><volume>635</volume><spage>122691</spage><epage>122691</epage><pages>122691-122691</pages><artnum>122691</artnum><issn>0378-5173</issn><eissn>1873-3476</eissn><abstract>[Display omitted]
Consistent powder micro-feeding (<100 g/h) is a significant challenge in manufacturing solid oral dosage forms. The low dose feeding can well control the content consistency of the dosage forms, which improves drug efficiency and reduces manufacturing waste. Current commercial micro-feeders are limited in their ability to feed < 20 g/h of cohesive (i.e. powders of poor flowability) active pharmaceutical ingredients (API) and excipients (e.g. lubricants) with low fluctuation. To breach this gap, this study presents an advanced micro-feeder design capable of feeding a range of pharmaceutical-grade powders consistently at flow rates as low as 0.7 g/h with <20 % flow rate variation. This was possible due to a novel powder conveying concept utilising particle re-entrainment to minimise flow rate variations. This work details the design of this pneumatic micro-feeder and its excellent micro-feeding performance even for cohesive powders. The experimental studies investigated the influence of the process parameters (air pressure and air flow rate) and equipment configurations (insert size and plug position) on the feeding performance of different pharmaceutical-relevant powders, i.e., microcrystalline cellulose (MCC), croscarmellose sodium (CCS), crospovidone (XPVP) and paracetamol (APAP). It was shown that the system is capable of delivering consistent powder flow rates with good repeatability and stability.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>36764420</pmid><doi>10.1016/j.ijpharm.2023.122691</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-0411-733X</orcidid><orcidid>https://orcid.org/0000-0002-0671-822X</orcidid><orcidid>https://orcid.org/0000-0001-5166-8869</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | International journal of pharmaceutics, 2023-03, Vol.635, p.122691-122691, Article 122691 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Carboxymethylcellulose Sodium Continuous feeding Excipients - chemistry High accuracy Micro-feeding Particle Size Pneumatic transferring Powder feeding Powders - chemistry Technology, Pharmaceutical |
| title | Development and implementation of a pneumatic micro-feeder for poorly-flowing solid pharmaceutical materials |
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