The atheroprotective role of fucoidan involves the reduction of foam cell formation by altering cholesterol flux-associated factors in macrophages

Atherosclerosis is characterized by the accumulation of lipid-laden cells in the arterial walls, resulting from dysregulation of cholesterol homeostasis in the macrophage, triggered by oxidized low-density lipoprotein (oxLDL). Previous studies have shown that fucoidan, a sulfated polysaccharide from...

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Veröffentlicht in:	Biochemical and biophysical research communications 2023-04, Vol.650, p.21-29
Hauptverfasser:	Fernandes-Braga, Weslley, Aguilar, Edenil Costa, Navia-Pelaez, Juliana Maria, Ávila, Danielle Lima, Rezende, Luisa, Andrade, Luciana de Oliveira, Miranda, Sued Eustáquio Mendes, Barros, Andre Luis Branco de, Capettini, Luciano dos Santos Aggum, Alvarez-Leite, Jacqueline Isaura
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apolipoproteins E - metabolism Atherosclerosis Atherosclerosis - metabolism brown algae Cholesterol - metabolism Dyslipidemia Foam Cells - metabolism Fucoidan absorption Lipoproteins, LDL - metabolism Macrophages - metabolism Mice Mice, Knockout, ApoE oxLDL Polysaccharides - metabolism Receptors, Scavenger - metabolism Tissue Distribution
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