Inhibitor of nuclear factor kappa B kinase subunit epsilon regulates murine acetaminophen toxicity via RIPK1/JNK

Drug-induced liver injury (DILI) still poses a major clinical challenge and is a leading cause of acute liver failure. Inhibitor of nuclear factor kappa B kinase subunit epsilon (IKBKE) is essential for inflammation and metabolic disorders. However, it is unclear how IKBKE regulates cellular damage...

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Veröffentlicht in:	Cell biology and toxicology 2023-12, Vol.39 (6), p.2709-2724
Hauptverfasser:	Xu, Yujie, Xu, Haozhe, Ling, Tao, Cui, Yachao, Zhang, Junwei, Mu, Xianmin, Zhou, Desheng, Zhao, Ting, Li, Yingchang, Su, Zhongping, You, Qiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen Acetaminophen - toxicity Analgesics Animals Biochemistry Biomedical and Life Sciences Cell Biology Chemical and Drug Induced Liver Injury - metabolism Damage Glutathione Glutathione - metabolism Hepatocytes Hepatocytes - metabolism Hepatotoxicity Inflammation Injuries JNK Mitogen-Activated Protein Kinases - metabolism Kinases Leukocytes (neutrophilic) Life Sciences Liver Metabolic disorders Mice Mice, Inbred C57BL Mitochondria - metabolism Monocytes NF-kappaB-Inducing Kinase Pharmacology/Toxicology Translocation
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