Development of a population pharmacokinetic model and optimal dosing regimen of leflunomide in Korean population

Leflunomide is an immunosuppressive drug indicated for the treatment of rheumatoid arthritis (RA). While the pharmacokinetics (PK) of its active metabolite A771726 reportedly show large interindividual variability, no efficient dose individualization strategy is currently available. The goal of this...

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Veröffentlicht in:	European journal of pharmaceutical sciences 2023-05, Vol.184, p.106402-106402, Article 106402
Hauptverfasser:	Shin, Yesong, Chae, Dongwoo, Park, Kyungsoo
Format:	Artikel
Sprache:	eng
Schlagworte:	Allometry Crotonates Dose optimization Enterohepatic circulation Humans Leflunomide Male Population pharmacokinetic model Republic of Korea Toluidines
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