Polymorphisms in hormonal-related genes might be associated with variations in permanent tooth crown size
The variability in tooth crown size (TCS) is influenced by genetic factors and might be regulated by the difference in hormonal response. This study aimed to evaluate the association between variations in TCS of permanent teeth with associated factors and genetic polymorphisms in hormonal-related ge...
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| Veröffentlicht in: | Orthodontics & craniofacial research 2023-11, Vol.26 (4), p.539-545 |
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| creator | Gerber, Jennifer Tsi Weiss, Suyany Gabriely Mijolaro, Laura Vidal Silva, Carolina Siqueira Petinati, Maria Fernanda Pivetta Meger, Michelle Nascimento Honório, Heitor Marques Rebellato, Nelson Luis Barbosa Sebastiani, Aline Monise Küchler, Erika Calvano Scariot, Rafaela |
| description | The variability in tooth crown size (TCS) is influenced by genetic factors and might be regulated by the difference in hormonal response.
This study aimed to evaluate the association between variations in TCS of permanent teeth with associated factors and genetic polymorphisms in hormonal-related genes (ESR1, ESR2 and PTH). This cross-sectional study involved dental casts from 86 individuals of both sexes. Dental casts were used to determine the maximum TCS of all fully erupted permanent teeth (except third molars) in the mesiodistal (MD) and buccolingual (BL) dimensions. Data such as sex, ethnicity, dental group (incisor, canine, premolar and molar), dental arch (upper and lower) and genetic polymorphisms of hormonal-related genes were used. The DNA from each patient was collected to evaluate the genetic polymorphisms in ESR1 (rs2234693 and rs9340799), ESR2 (rs1256049 and rs4986938) and PTH (rs694, rs6256 and rs307247) through real-time PCR. The data were submitted to statistical analysis with a significance level of 0.05.
In the MD dimension, the sex, dental group and dental arch were associated with variation in TCS (P |
| doi_str_mv | 10.1111/ocr.12638 |
| format | Article |
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This study aimed to evaluate the association between variations in TCS of permanent teeth with associated factors and genetic polymorphisms in hormonal-related genes (ESR1, ESR2 and PTH). This cross-sectional study involved dental casts from 86 individuals of both sexes. Dental casts were used to determine the maximum TCS of all fully erupted permanent teeth (except third molars) in the mesiodistal (MD) and buccolingual (BL) dimensions. Data such as sex, ethnicity, dental group (incisor, canine, premolar and molar), dental arch (upper and lower) and genetic polymorphisms of hormonal-related genes were used. The DNA from each patient was collected to evaluate the genetic polymorphisms in ESR1 (rs2234693 and rs9340799), ESR2 (rs1256049 and rs4986938) and PTH (rs694, rs6256 and rs307247) through real-time PCR. The data were submitted to statistical analysis with a significance level of 0.05.
In the MD dimension, the sex, dental group and dental arch were associated with variation in TCS (P < .05). In the BL dimension, the sex, dental group, dental arch and polymorphism in rs694 and rs307247 were associated with variation in TCS.
In short, this study suggests that genetic polymorphisms of PTH are associated with variations in the BL TCS of permanent human teeth.</description><identifier>ISSN: 1601-6335</identifier><identifier>EISSN: 1601-6343</identifier><identifier>DOI: 10.1111/ocr.12638</identifier><identifier>PMID: 36756694</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>ESR1 protein ; Gene polymorphism ; Genetic factors ; Molars ; Parathyroid hormone ; Sex ; Statistical analysis ; Teeth ; Variation</subject><ispartof>Orthodontics & craniofacial research, 2023-11, Vol.26 (4), p.539-545</ispartof><rights>2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2023 John Wiley & Sons A/S</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c313t-551f56c2ef21a809db6034f67fc2d4b270be9653a9b1517594c4034bd663460a3</citedby><cites>FETCH-LOGICAL-c313t-551f56c2ef21a809db6034f67fc2d4b270be9653a9b1517594c4034bd663460a3</cites><orcidid>0000-0002-4911-6413 ; 0000-0003-0231-3409</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36756694$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gerber, Jennifer Tsi</creatorcontrib><creatorcontrib>Weiss, Suyany Gabriely</creatorcontrib><creatorcontrib>Mijolaro, Laura Vidal</creatorcontrib><creatorcontrib>Silva, Carolina Siqueira</creatorcontrib><creatorcontrib>Petinati, Maria Fernanda Pivetta</creatorcontrib><creatorcontrib>Meger, Michelle Nascimento</creatorcontrib><creatorcontrib>Honório, Heitor Marques</creatorcontrib><creatorcontrib>Rebellato, Nelson Luis Barbosa</creatorcontrib><creatorcontrib>Sebastiani, Aline Monise</creatorcontrib><creatorcontrib>Küchler, Erika Calvano</creatorcontrib><creatorcontrib>Scariot, Rafaela</creatorcontrib><title>Polymorphisms in hormonal-related genes might be associated with variations in permanent tooth crown size</title><title>Orthodontics & craniofacial research</title><addtitle>Orthod Craniofac Res</addtitle><description>The variability in tooth crown size (TCS) is influenced by genetic factors and might be regulated by the difference in hormonal response.
This study aimed to evaluate the association between variations in TCS of permanent teeth with associated factors and genetic polymorphisms in hormonal-related genes (ESR1, ESR2 and PTH). This cross-sectional study involved dental casts from 86 individuals of both sexes. Dental casts were used to determine the maximum TCS of all fully erupted permanent teeth (except third molars) in the mesiodistal (MD) and buccolingual (BL) dimensions. Data such as sex, ethnicity, dental group (incisor, canine, premolar and molar), dental arch (upper and lower) and genetic polymorphisms of hormonal-related genes were used. The DNA from each patient was collected to evaluate the genetic polymorphisms in ESR1 (rs2234693 and rs9340799), ESR2 (rs1256049 and rs4986938) and PTH (rs694, rs6256 and rs307247) through real-time PCR. The data were submitted to statistical analysis with a significance level of 0.05.
In the MD dimension, the sex, dental group and dental arch were associated with variation in TCS (P < .05). In the BL dimension, the sex, dental group, dental arch and polymorphism in rs694 and rs307247 were associated with variation in TCS.
In short, this study suggests that genetic polymorphisms of PTH are associated with variations in the BL TCS of permanent human teeth.</description><subject>ESR1 protein</subject><subject>Gene polymorphism</subject><subject>Genetic factors</subject><subject>Molars</subject><subject>Parathyroid hormone</subject><subject>Sex</subject><subject>Statistical analysis</subject><subject>Teeth</subject><subject>Variation</subject><issn>1601-6335</issn><issn>1601-6343</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpdkDtPwzAUhS0EoqUw8AeQJRYYUvxOMqKKl1QJBpgjx3EaV3Ec7JSq_HpMWzpwF1_rfD7yOQBcYjTFce6c8lNMBM2OwBgLhBNBGT0-7JSPwFkIS4QIIkScghEVKRciZ2Ng3ly7sc73jQk2QNPBxnnrOtkmXrdy0BVc6E4HaM2iGWCpoQzBKbNV1mZo4Jf08WZct33da29lp7sBDs5FVXm37mAw3_ocnNSyDfpif07Ax-PD--w5mb8-vczu54mimA4J57jmQhFdEywzlFelQJTVIq0VqVhJUlTqXHAq8xJznPKcKRaBshIxtECSTsDNzrf37nOlw1BYE5Ru2_gttwoFSVOW5QxF2wm4_ocu3crH7JHKUswFJySL1O2OillC8Louem-s9JsCo-K3_yL2X2z7j-zV3nFVWl0dyL_C6Q_RyYCw</recordid><startdate>20231101</startdate><enddate>20231101</enddate><creator>Gerber, Jennifer Tsi</creator><creator>Weiss, Suyany Gabriely</creator><creator>Mijolaro, Laura Vidal</creator><creator>Silva, Carolina Siqueira</creator><creator>Petinati, Maria Fernanda Pivetta</creator><creator>Meger, Michelle Nascimento</creator><creator>Honório, Heitor Marques</creator><creator>Rebellato, Nelson Luis Barbosa</creator><creator>Sebastiani, Aline Monise</creator><creator>Küchler, Erika Calvano</creator><creator>Scariot, Rafaela</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4911-6413</orcidid><orcidid>https://orcid.org/0000-0003-0231-3409</orcidid></search><sort><creationdate>20231101</creationdate><title>Polymorphisms in hormonal-related genes might be associated with variations in permanent tooth crown size</title><author>Gerber, Jennifer Tsi ; Weiss, Suyany Gabriely ; Mijolaro, Laura Vidal ; Silva, Carolina Siqueira ; Petinati, Maria Fernanda Pivetta ; Meger, Michelle Nascimento ; Honório, Heitor Marques ; Rebellato, Nelson Luis Barbosa ; Sebastiani, Aline Monise ; Küchler, Erika Calvano ; Scariot, Rafaela</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c313t-551f56c2ef21a809db6034f67fc2d4b270be9653a9b1517594c4034bd663460a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>ESR1 protein</topic><topic>Gene polymorphism</topic><topic>Genetic factors</topic><topic>Molars</topic><topic>Parathyroid hormone</topic><topic>Sex</topic><topic>Statistical analysis</topic><topic>Teeth</topic><topic>Variation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gerber, Jennifer Tsi</creatorcontrib><creatorcontrib>Weiss, Suyany Gabriely</creatorcontrib><creatorcontrib>Mijolaro, Laura Vidal</creatorcontrib><creatorcontrib>Silva, Carolina Siqueira</creatorcontrib><creatorcontrib>Petinati, Maria Fernanda Pivetta</creatorcontrib><creatorcontrib>Meger, Michelle Nascimento</creatorcontrib><creatorcontrib>Honório, Heitor Marques</creatorcontrib><creatorcontrib>Rebellato, Nelson Luis Barbosa</creatorcontrib><creatorcontrib>Sebastiani, Aline Monise</creatorcontrib><creatorcontrib>Küchler, Erika Calvano</creatorcontrib><creatorcontrib>Scariot, Rafaela</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Orthodontics & craniofacial research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gerber, Jennifer Tsi</au><au>Weiss, Suyany Gabriely</au><au>Mijolaro, Laura Vidal</au><au>Silva, Carolina Siqueira</au><au>Petinati, Maria Fernanda Pivetta</au><au>Meger, Michelle Nascimento</au><au>Honório, Heitor Marques</au><au>Rebellato, Nelson Luis Barbosa</au><au>Sebastiani, Aline Monise</au><au>Küchler, Erika Calvano</au><au>Scariot, Rafaela</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polymorphisms in hormonal-related genes might be associated with variations in permanent tooth crown size</atitle><jtitle>Orthodontics & craniofacial research</jtitle><addtitle>Orthod Craniofac Res</addtitle><date>2023-11-01</date><risdate>2023</risdate><volume>26</volume><issue>4</issue><spage>539</spage><epage>545</epage><pages>539-545</pages><issn>1601-6335</issn><eissn>1601-6343</eissn><abstract>The variability in tooth crown size (TCS) is influenced by genetic factors and might be regulated by the difference in hormonal response.
This study aimed to evaluate the association between variations in TCS of permanent teeth with associated factors and genetic polymorphisms in hormonal-related genes (ESR1, ESR2 and PTH). This cross-sectional study involved dental casts from 86 individuals of both sexes. Dental casts were used to determine the maximum TCS of all fully erupted permanent teeth (except third molars) in the mesiodistal (MD) and buccolingual (BL) dimensions. Data such as sex, ethnicity, dental group (incisor, canine, premolar and molar), dental arch (upper and lower) and genetic polymorphisms of hormonal-related genes were used. The DNA from each patient was collected to evaluate the genetic polymorphisms in ESR1 (rs2234693 and rs9340799), ESR2 (rs1256049 and rs4986938) and PTH (rs694, rs6256 and rs307247) through real-time PCR. The data were submitted to statistical analysis with a significance level of 0.05.
In the MD dimension, the sex, dental group and dental arch were associated with variation in TCS (P < .05). In the BL dimension, the sex, dental group, dental arch and polymorphism in rs694 and rs307247 were associated with variation in TCS.
In short, this study suggests that genetic polymorphisms of PTH are associated with variations in the BL TCS of permanent human teeth.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>36756694</pmid><doi>10.1111/ocr.12638</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-4911-6413</orcidid><orcidid>https://orcid.org/0000-0003-0231-3409</orcidid></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | ESR1 protein Gene polymorphism Genetic factors Molars Parathyroid hormone Sex Statistical analysis Teeth Variation |
| title | Polymorphisms in hormonal-related genes might be associated with variations in permanent tooth crown size |
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