KLF14/miR‐1283/TFAP2C axis inhibits HER2‐positive breast cancer progression via declining tumor cell proliferation

MiR‐1283 has been identified as a tumor suppressor in some malignancies. Whereas, the role of miR‐1283 in HER2‐positive (HER2+) breast cancer, particularly its role in regulating cell proliferation, one of the most significant features of tumor progression, is unclear. The related microRNA screened...

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Veröffentlicht in:	Molecular carcinogenesis 2023-04, Vol.62 (4), p.532-545
Hauptverfasser:	Chen, Xue‐Zhong, He, Wen‐Xing, Luo, Rong‐Guang, Xia, Guo‐Jin, Zhong, Jin‐Xiu, Chen, Qing‐Jie, Huang, Yu‐Ying, Guan, Yan‐Xing
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated regions Animals Apoptosis Breast cancer Breast Neoplasms - metabolism Cell growth Cell Line, Tumor Cell proliferation Cell Proliferation - genetics ErbB-2 protein Female Gene Expression Regulation, Neoplastic HER2 Humans KLF14 Kruppel-Like Transcription Factors - genetics Kruppel-Like Transcription Factors - metabolism Malignancy Mice MicroRNAs - metabolism miRNA miR‐1283 mRNA proliferation TFAP2C Transcription Factor AP-2 - genetics Transcription factors Transcription Factors - genetics Tumor cell lines Tumor suppressor genes Tumors Xenografts
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