Functionalized MoS2: circular economy SERS substrate for label-free detection of bilirubin in clinical diagnosis
A one-pot hydrothermal synthesis of Fe-doped MoS 2 nanoflowers (Fe-MoS 2 NFs) has been developed as a surface-enhanced Raman spectroscopy (SERS) substrate. The Fe-MoS 2 NFs display high reproducibility, stability, and recyclability, which is beneficial for the development of the sustainable ecologic...
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| Veröffentlicht in: | Mikrochimica acta (1966) 2023-03, Vol.190 (3), p.83-83, Article 83 |
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| container_title | Mikrochimica acta (1966) |
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| creator | Li, Jia Yang, Tingru Lang, Jihui Liu, Huilian Gao, Ming |
| description | A one-pot hydrothermal synthesis of Fe-doped MoS
2
nanoflowers (Fe-MoS
2
NFs) has been developed as a surface-enhanced Raman spectroscopy (SERS) substrate. The Fe-MoS
2
NFs display high reproducibility, stability, and recyclability, which is beneficial for the development of the sustainable ecological environment. The SERS substrate provides a high enhancement factor of 10
5
, which can be ascribed to the inducing defects by doping Fe that can improve the charge transfer between probe molecules and MoS
2
. The Fe-MoS
2
NFs have been used to detect bilirubin in serum. The Fe-MoS
2
NF SERS substrate exhibits a linear detection range from 10
−3
to 10
−9
M with a low limit of detection (LOD) of 10
−8
M. The substrate displays an excellent selectivity to bilirubin in the presence of other potentially interfering molecules (dextrose and phosphate). These results provide a novel concept to synthesize ultra-sensitive SERS substrates and open up a wide range of possibilities for new applications of MoS
2
in clinical diagnosis.
Graphical Abstract |
| doi_str_mv | 10.1007/s00604-023-05668-4 |
| format | Article |
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2
nanoflowers (Fe-MoS
2
NFs) has been developed as a surface-enhanced Raman spectroscopy (SERS) substrate. The Fe-MoS
2
NFs display high reproducibility, stability, and recyclability, which is beneficial for the development of the sustainable ecological environment. The SERS substrate provides a high enhancement factor of 10
5
, which can be ascribed to the inducing defects by doping Fe that can improve the charge transfer between probe molecules and MoS
2
. The Fe-MoS
2
NFs have been used to detect bilirubin in serum. The Fe-MoS
2
NF SERS substrate exhibits a linear detection range from 10
−3
to 10
−9
M with a low limit of detection (LOD) of 10
−8
M. The substrate displays an excellent selectivity to bilirubin in the presence of other potentially interfering molecules (dextrose and phosphate). These results provide a novel concept to synthesize ultra-sensitive SERS substrates and open up a wide range of possibilities for new applications of MoS
2
in clinical diagnosis.
Graphical Abstract</description><identifier>ISSN: 0026-3672</identifier><identifier>EISSN: 1436-5073</identifier><identifier>DOI: 10.1007/s00604-023-05668-4</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Analytical Chemistry ; Characterization and Evaluation of Materials ; Charge transfer ; Chemistry ; Chemistry and Materials Science ; Circular economy ; Dextrose ; Diagnosis ; Microengineering ; Molybdenum disulfide ; Nanochemistry ; Nanotechnology ; Original Paper ; Raman spectroscopy ; Recyclability ; Selectivity ; Substrates</subject><ispartof>Mikrochimica acta (1966), 2023-03, Vol.190 (3), p.83-83, Article 83</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c352t-266e40842524029c3926265e0755946de04a015dd3f3c12348eca0452f229ff53</citedby><cites>FETCH-LOGICAL-c352t-266e40842524029c3926265e0755946de04a015dd3f3c12348eca0452f229ff53</cites><orcidid>0000-0003-3830-7393</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00604-023-05668-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00604-023-05668-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids></links><search><creatorcontrib>Li, Jia</creatorcontrib><creatorcontrib>Yang, Tingru</creatorcontrib><creatorcontrib>Lang, Jihui</creatorcontrib><creatorcontrib>Liu, Huilian</creatorcontrib><creatorcontrib>Gao, Ming</creatorcontrib><title>Functionalized MoS2: circular economy SERS substrate for label-free detection of bilirubin in clinical diagnosis</title><title>Mikrochimica acta (1966)</title><addtitle>Microchim Acta</addtitle><description>A one-pot hydrothermal synthesis of Fe-doped MoS
2
nanoflowers (Fe-MoS
2
NFs) has been developed as a surface-enhanced Raman spectroscopy (SERS) substrate. The Fe-MoS
2
NFs display high reproducibility, stability, and recyclability, which is beneficial for the development of the sustainable ecological environment. The SERS substrate provides a high enhancement factor of 10
5
, which can be ascribed to the inducing defects by doping Fe that can improve the charge transfer between probe molecules and MoS
2
. The Fe-MoS
2
NFs have been used to detect bilirubin in serum. The Fe-MoS
2
NF SERS substrate exhibits a linear detection range from 10
−3
to 10
−9
M with a low limit of detection (LOD) of 10
−8
M. The substrate displays an excellent selectivity to bilirubin in the presence of other potentially interfering molecules (dextrose and phosphate). These results provide a novel concept to synthesize ultra-sensitive SERS substrates and open up a wide range of possibilities for new applications of MoS
2
in clinical diagnosis.
Graphical Abstract</description><subject>Analytical Chemistry</subject><subject>Characterization and Evaluation of Materials</subject><subject>Charge transfer</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Circular economy</subject><subject>Dextrose</subject><subject>Diagnosis</subject><subject>Microengineering</subject><subject>Molybdenum disulfide</subject><subject>Nanochemistry</subject><subject>Nanotechnology</subject><subject>Original Paper</subject><subject>Raman spectroscopy</subject><subject>Recyclability</subject><subject>Selectivity</subject><subject>Substrates</subject><issn>0026-3672</issn><issn>1436-5073</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kU1rGzEURUVoIG6SP5CVIJtulL55-hi7u2KctOBSiJO1kDVPQUEeudLMwv31mdiFQheFB29z7l3cw9hNA3cNQPu5AhhQAlAK0MbMhTpjs0ZJIzS08gObAaAR0rR4wT7W-grQtAbVjO3vx94PMfcuxd_U8R95g1-4j8WPyRVOPvd5d-Cb1eOG13Fbh-IG4iEXntyWkgiFiHc00LGE58C3McUybmPPp_Mp9tG7xLvoXvpcY71i58GlStd__iV7vl89Lb-J9c-H78uva-GlxkGgMaRgrlCjAlx4uUCDRhO0Wi-U6QiUg0Z3nQzSNyjVnLwDpTEgLkLQ8pJ9OvXuS_41Uh3sLlZPKbme8lgttq1C04LBCb39B33NY5kWOVJyPk2o1EThifIl11oo2H2JO1cOtgH7LsGeJNhJgj1KsO8heQrVCe5fqPyt_k_qDYo1iMA</recordid><startdate>20230301</startdate><enddate>20230301</enddate><creator>Li, Jia</creator><creator>Yang, Tingru</creator><creator>Lang, Jihui</creator><creator>Liu, Huilian</creator><creator>Gao, Ming</creator><general>Springer Vienna</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3830-7393</orcidid></search><sort><creationdate>20230301</creationdate><title>Functionalized MoS2: circular economy SERS substrate for label-free detection of bilirubin in clinical diagnosis</title><author>Li, Jia ; Yang, Tingru ; Lang, Jihui ; Liu, Huilian ; Gao, Ming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-266e40842524029c3926265e0755946de04a015dd3f3c12348eca0452f229ff53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Analytical Chemistry</topic><topic>Characterization and Evaluation of Materials</topic><topic>Charge transfer</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Circular economy</topic><topic>Dextrose</topic><topic>Diagnosis</topic><topic>Microengineering</topic><topic>Molybdenum disulfide</topic><topic>Nanochemistry</topic><topic>Nanotechnology</topic><topic>Original Paper</topic><topic>Raman spectroscopy</topic><topic>Recyclability</topic><topic>Selectivity</topic><topic>Substrates</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Jia</creatorcontrib><creatorcontrib>Yang, Tingru</creatorcontrib><creatorcontrib>Lang, Jihui</creatorcontrib><creatorcontrib>Liu, Huilian</creatorcontrib><creatorcontrib>Gao, Ming</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Mikrochimica acta (1966)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Jia</au><au>Yang, Tingru</au><au>Lang, Jihui</au><au>Liu, Huilian</au><au>Gao, Ming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functionalized MoS2: circular economy SERS substrate for label-free detection of bilirubin in clinical diagnosis</atitle><jtitle>Mikrochimica acta (1966)</jtitle><stitle>Microchim Acta</stitle><date>2023-03-01</date><risdate>2023</risdate><volume>190</volume><issue>3</issue><spage>83</spage><epage>83</epage><pages>83-83</pages><artnum>83</artnum><issn>0026-3672</issn><eissn>1436-5073</eissn><abstract>A one-pot hydrothermal synthesis of Fe-doped MoS
2
nanoflowers (Fe-MoS
2
NFs) has been developed as a surface-enhanced Raman spectroscopy (SERS) substrate. The Fe-MoS
2
NFs display high reproducibility, stability, and recyclability, which is beneficial for the development of the sustainable ecological environment. The SERS substrate provides a high enhancement factor of 10
5
, which can be ascribed to the inducing defects by doping Fe that can improve the charge transfer between probe molecules and MoS
2
. The Fe-MoS
2
NFs have been used to detect bilirubin in serum. The Fe-MoS
2
NF SERS substrate exhibits a linear detection range from 10
−3
to 10
−9
M with a low limit of detection (LOD) of 10
−8
M. The substrate displays an excellent selectivity to bilirubin in the presence of other potentially interfering molecules (dextrose and phosphate). These results provide a novel concept to synthesize ultra-sensitive SERS substrates and open up a wide range of possibilities for new applications of MoS
2
in clinical diagnosis.
Graphical Abstract</abstract><cop>Vienna</cop><pub>Springer Vienna</pub><doi>10.1007/s00604-023-05668-4</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-3830-7393</orcidid></addata></record> |
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| ispartof | Mikrochimica acta (1966), 2023-03, Vol.190 (3), p.83-83, Article 83 |
| issn | 0026-3672 1436-5073 |
| language | eng |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Analytical Chemistry Characterization and Evaluation of Materials Charge transfer Chemistry Chemistry and Materials Science Circular economy Dextrose Diagnosis Microengineering Molybdenum disulfide Nanochemistry Nanotechnology Original Paper Raman spectroscopy Recyclability Selectivity Substrates |
| title | Functionalized MoS2: circular economy SERS substrate for label-free detection of bilirubin in clinical diagnosis |
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