A three‐gene leukaemic stem cell signature score is robustly prognostic in chronic myelomonocytic leukaemia
Summary Leukaemic stem cell (LSC) gene expression has recently been linked to prognosis in patients with acute myeloid leukaemia (17‐gene LSC score, LSC‐17) and myelodysplastic syndromes. Although chronic myelomonocytic leukaemia (CMML) is regarded as a stem cell disorder, the clinical and biologica...
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| Veröffentlicht in: | British journal of haematology 2023-04, Vol.201 (2), p.302-307 |
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| creator | Wang, Yu‐Hung Yao, Chi‐Yuan Lin, Chien‐Chin Gurashi, Kristian Amaral, Fabio M. R. Bossenbroek, Hasse Jerez, Andres Somervaille, Tim C. P. Binder, Moritz Patnaik, Mrinal M. Hou, Hsin‐An Chou, Wen‐Chien Batta, Kiran Wiseman, Daniel H. Tien, Hwei‐Fang |
| description | Summary
Leukaemic stem cell (LSC) gene expression has recently been linked to prognosis in patients with acute myeloid leukaemia (17‐gene LSC score, LSC‐17) and myelodysplastic syndromes. Although chronic myelomonocytic leukaemia (CMML) is regarded as a stem cell disorder, the clinical and biological impact of LSCs on CMML patients remains elusive. Making use of multiple independent validation cohorts, we here describe a concise three‐gene expression signature (LSC‐3, derived from the LSC‐17 score) as an independent and robust prognostic factor for leukaemia‐free and overall survival in CMML. We propose that LSC‐3 could be used to supplement existing risk stratification systems, to improve prognostic performance and guide management decisions. |
| doi_str_mv | 10.1111/bjh.18681 |
| format | Article |
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Leukaemic stem cell (LSC) gene expression has recently been linked to prognosis in patients with acute myeloid leukaemia (17‐gene LSC score, LSC‐17) and myelodysplastic syndromes. Although chronic myelomonocytic leukaemia (CMML) is regarded as a stem cell disorder, the clinical and biological impact of LSCs on CMML patients remains elusive. Making use of multiple independent validation cohorts, we here describe a concise three‐gene expression signature (LSC‐3, derived from the LSC‐17 score) as an independent and robust prognostic factor for leukaemia‐free and overall survival in CMML. We propose that LSC‐3 could be used to supplement existing risk stratification systems, to improve prognostic performance and guide management decisions.</description><identifier>ISSN: 0007-1048</identifier><identifier>EISSN: 1365-2141</identifier><identifier>DOI: 10.1111/bjh.18681</identifier><identifier>PMID: 36746431</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Acute myeloid leukemia ; chronic myelomonocytic leukaemia ; Chronic myelomonocytic leukemia ; Gene expression ; Hematology ; Humans ; leukaemia stem cell ; Leukemia, Myeloid, Acute ; Leukemia, Myelomonocytic, Chronic - diagnosis ; Leukemia, Myelomonocytic, Chronic - genetics ; Myelodysplastic syndrome ; Myelodysplastic Syndromes ; Prognosis ; prognostic scoring system ; Stem Cells</subject><ispartof>British journal of haematology, 2023-04, Vol.201 (2), p.302-307</ispartof><rights>2023 British Society for Haematology and John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3131-b61d93ff019df4947017079901eab8e44a52d6d2b0d79911cdc398c8cf50f19f3</cites><orcidid>0000-0003-2967-698X ; 0000-0001-9014-9658 ; 0000-0003-4483-5627 ; 0000-0001-7160-2285 ; 0000-0001-5052-9445 ; 0000-0002-2079-6638 ; 0000-0003-0715-1402</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fbjh.18681$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fbjh.18681$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36746431$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Yu‐Hung</creatorcontrib><creatorcontrib>Yao, Chi‐Yuan</creatorcontrib><creatorcontrib>Lin, Chien‐Chin</creatorcontrib><creatorcontrib>Gurashi, Kristian</creatorcontrib><creatorcontrib>Amaral, Fabio M. R.</creatorcontrib><creatorcontrib>Bossenbroek, Hasse</creatorcontrib><creatorcontrib>Jerez, Andres</creatorcontrib><creatorcontrib>Somervaille, Tim C. P.</creatorcontrib><creatorcontrib>Binder, Moritz</creatorcontrib><creatorcontrib>Patnaik, Mrinal M.</creatorcontrib><creatorcontrib>Hou, Hsin‐An</creatorcontrib><creatorcontrib>Chou, Wen‐Chien</creatorcontrib><creatorcontrib>Batta, Kiran</creatorcontrib><creatorcontrib>Wiseman, Daniel H.</creatorcontrib><creatorcontrib>Tien, Hwei‐Fang</creatorcontrib><title>A three‐gene leukaemic stem cell signature score is robustly prognostic in chronic myelomonocytic leukaemia</title><title>British journal of haematology</title><addtitle>Br J Haematol</addtitle><description>Summary
Leukaemic stem cell (LSC) gene expression has recently been linked to prognosis in patients with acute myeloid leukaemia (17‐gene LSC score, LSC‐17) and myelodysplastic syndromes. Although chronic myelomonocytic leukaemia (CMML) is regarded as a stem cell disorder, the clinical and biological impact of LSCs on CMML patients remains elusive. Making use of multiple independent validation cohorts, we here describe a concise three‐gene expression signature (LSC‐3, derived from the LSC‐17 score) as an independent and robust prognostic factor for leukaemia‐free and overall survival in CMML. We propose that LSC‐3 could be used to supplement existing risk stratification systems, to improve prognostic performance and guide management decisions.</description><subject>Acute myeloid leukemia</subject><subject>chronic myelomonocytic leukaemia</subject><subject>Chronic myelomonocytic leukemia</subject><subject>Gene expression</subject><subject>Hematology</subject><subject>Humans</subject><subject>leukaemia stem cell</subject><subject>Leukemia, Myeloid, Acute</subject><subject>Leukemia, Myelomonocytic, Chronic - diagnosis</subject><subject>Leukemia, Myelomonocytic, Chronic - genetics</subject><subject>Myelodysplastic syndrome</subject><subject>Myelodysplastic Syndromes</subject><subject>Prognosis</subject><subject>prognostic scoring system</subject><subject>Stem Cells</subject><issn>0007-1048</issn><issn>1365-2141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1OwzAQhS0EglJYcAFkiQ0s0npix4mXgPgVEhtYR4kzaVOSGOxEKDuOwBk5CS5tWSDhxdgaf_P07EfIEbAJ-DXNF_MJJDKBLTICLqMgBAHbZMQYiwNgItkj-84tGAPOItgle1zGQgoOI9Kc025uEb8-PmfYIq2xf8mwqTR1HTZUY11TV83arOstUqeNr5Wj1uS96-qBvloza43r_EDVUj23pvXHZsDaNKY1eljebESzA7JTZrXDw_U-Js_XV0-Xt8HD483d5flDoDlwCHIJheJlyUAVpVAiZhCzWCkGmOUJCpFFYSGLMGeF7wLoQnOV6ESXEStBlXxMTle63t5bj65Lm8ot35K1aHqXhnEsQimTKPboyR90YXrbeneeUlEYytB7GpOzFaWtcc5imb7aqsnskAJLlxmkPoP0JwPPHq8V-7zB4pfcfLoHpivgvapx-F8pvbi_XUl-A2y8ke4</recordid><startdate>202304</startdate><enddate>202304</enddate><creator>Wang, Yu‐Hung</creator><creator>Yao, Chi‐Yuan</creator><creator>Lin, Chien‐Chin</creator><creator>Gurashi, Kristian</creator><creator>Amaral, Fabio M. R.</creator><creator>Bossenbroek, Hasse</creator><creator>Jerez, Andres</creator><creator>Somervaille, Tim C. P.</creator><creator>Binder, Moritz</creator><creator>Patnaik, Mrinal M.</creator><creator>Hou, Hsin‐An</creator><creator>Chou, Wen‐Chien</creator><creator>Batta, Kiran</creator><creator>Wiseman, Daniel H.</creator><creator>Tien, Hwei‐Fang</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2967-698X</orcidid><orcidid>https://orcid.org/0000-0001-9014-9658</orcidid><orcidid>https://orcid.org/0000-0003-4483-5627</orcidid><orcidid>https://orcid.org/0000-0001-7160-2285</orcidid><orcidid>https://orcid.org/0000-0001-5052-9445</orcidid><orcidid>https://orcid.org/0000-0002-2079-6638</orcidid><orcidid>https://orcid.org/0000-0003-0715-1402</orcidid></search><sort><creationdate>202304</creationdate><title>A three‐gene leukaemic stem cell signature score is robustly prognostic in chronic myelomonocytic leukaemia</title><author>Wang, Yu‐Hung ; Yao, Chi‐Yuan ; Lin, Chien‐Chin ; Gurashi, Kristian ; Amaral, Fabio M. R. ; Bossenbroek, Hasse ; Jerez, Andres ; Somervaille, Tim C. P. ; Binder, Moritz ; Patnaik, Mrinal M. ; Hou, Hsin‐An ; Chou, Wen‐Chien ; Batta, Kiran ; Wiseman, Daniel H. ; Tien, Hwei‐Fang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3131-b61d93ff019df4947017079901eab8e44a52d6d2b0d79911cdc398c8cf50f19f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Acute myeloid leukemia</topic><topic>chronic myelomonocytic leukaemia</topic><topic>Chronic myelomonocytic leukemia</topic><topic>Gene expression</topic><topic>Hematology</topic><topic>Humans</topic><topic>leukaemia stem cell</topic><topic>Leukemia, Myeloid, Acute</topic><topic>Leukemia, Myelomonocytic, Chronic - diagnosis</topic><topic>Leukemia, Myelomonocytic, Chronic - genetics</topic><topic>Myelodysplastic syndrome</topic><topic>Myelodysplastic Syndromes</topic><topic>Prognosis</topic><topic>prognostic scoring system</topic><topic>Stem Cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Yu‐Hung</creatorcontrib><creatorcontrib>Yao, Chi‐Yuan</creatorcontrib><creatorcontrib>Lin, Chien‐Chin</creatorcontrib><creatorcontrib>Gurashi, Kristian</creatorcontrib><creatorcontrib>Amaral, Fabio M. R.</creatorcontrib><creatorcontrib>Bossenbroek, Hasse</creatorcontrib><creatorcontrib>Jerez, Andres</creatorcontrib><creatorcontrib>Somervaille, Tim C. P.</creatorcontrib><creatorcontrib>Binder, Moritz</creatorcontrib><creatorcontrib>Patnaik, Mrinal M.</creatorcontrib><creatorcontrib>Hou, Hsin‐An</creatorcontrib><creatorcontrib>Chou, Wen‐Chien</creatorcontrib><creatorcontrib>Batta, Kiran</creatorcontrib><creatorcontrib>Wiseman, Daniel H.</creatorcontrib><creatorcontrib>Tien, Hwei‐Fang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Yu‐Hung</au><au>Yao, Chi‐Yuan</au><au>Lin, Chien‐Chin</au><au>Gurashi, Kristian</au><au>Amaral, Fabio M. R.</au><au>Bossenbroek, Hasse</au><au>Jerez, Andres</au><au>Somervaille, Tim C. P.</au><au>Binder, Moritz</au><au>Patnaik, Mrinal M.</au><au>Hou, Hsin‐An</au><au>Chou, Wen‐Chien</au><au>Batta, Kiran</au><au>Wiseman, Daniel H.</au><au>Tien, Hwei‐Fang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A three‐gene leukaemic stem cell signature score is robustly prognostic in chronic myelomonocytic leukaemia</atitle><jtitle>British journal of haematology</jtitle><addtitle>Br J Haematol</addtitle><date>2023-04</date><risdate>2023</risdate><volume>201</volume><issue>2</issue><spage>302</spage><epage>307</epage><pages>302-307</pages><issn>0007-1048</issn><eissn>1365-2141</eissn><abstract>Summary
Leukaemic stem cell (LSC) gene expression has recently been linked to prognosis in patients with acute myeloid leukaemia (17‐gene LSC score, LSC‐17) and myelodysplastic syndromes. Although chronic myelomonocytic leukaemia (CMML) is regarded as a stem cell disorder, the clinical and biological impact of LSCs on CMML patients remains elusive. Making use of multiple independent validation cohorts, we here describe a concise three‐gene expression signature (LSC‐3, derived from the LSC‐17 score) as an independent and robust prognostic factor for leukaemia‐free and overall survival in CMML. We propose that LSC‐3 could be used to supplement existing risk stratification systems, to improve prognostic performance and guide management decisions.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>36746431</pmid><doi>10.1111/bjh.18681</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-2967-698X</orcidid><orcidid>https://orcid.org/0000-0001-9014-9658</orcidid><orcidid>https://orcid.org/0000-0003-4483-5627</orcidid><orcidid>https://orcid.org/0000-0001-7160-2285</orcidid><orcidid>https://orcid.org/0000-0001-5052-9445</orcidid><orcidid>https://orcid.org/0000-0002-2079-6638</orcidid><orcidid>https://orcid.org/0000-0003-0715-1402</orcidid></addata></record> |
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| subjects | Acute myeloid leukemia chronic myelomonocytic leukaemia Chronic myelomonocytic leukemia Gene expression Hematology Humans leukaemia stem cell Leukemia, Myeloid, Acute Leukemia, Myelomonocytic, Chronic - diagnosis Leukemia, Myelomonocytic, Chronic - genetics Myelodysplastic syndrome Myelodysplastic Syndromes Prognosis prognostic scoring system Stem Cells |
| title | A three‐gene leukaemic stem cell signature score is robustly prognostic in chronic myelomonocytic leukaemia |
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