Studies of Cytotoxicity Effects, SARS‐CoV‐2 Main Protease Inhibition, and in Silico Interactions of Synthetic Chalcones

SARS‐CoV‐2 main protease (Mpro) plays an essential role in proteolysis cleavage that promotes coronavirus replication. Thus, attenuating the activity of this enzyme represents a strategy to develop antiviral agents. We report inhibitory effects against Mpro of 40 synthetic chalcones, and cytotoxicit...

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Veröffentlicht in:	Chemistry & biodiversity 2023-03, Vol.20 (3), p.e202201151-n/a
Hauptverfasser:	Guterres Fernandes, Octavio L., Tizziani, Tiago, Dambrós, Bibiana P., Ferreira de Sousa, Natália, Mansur Pontes, Carime L., Silva, Layzon A. L., Escorteganha Pollo, Luiz A., Assis, Francisco F., Scotti, Marcus T., Scotti, Luciana, Braga, Antonio L., Steindel, Mario, Sandjo, Louis P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral agents Antiviral Agents - chemistry Antiviral Agents - pharmacology Binding Cell lines Chalcones - chemistry Chalcones - pharmacology Coronaviruses COVID-19 Cyclohexanethiol Cytotoxicity Hemolysis heterocyclic chalcones Humans inhibitory effects Molecular docking Molecular Docking Simulation Molecular Dynamics Simulation Protease Protease Inhibitors - chemistry Protease Inhibitors - pharmacology Proteolysis SARS-CoV-2 SARS-CoV-2 Mpro Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Toxicity
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