Exploring potential of diacerin nanogel for topical application in arthritis: Formulation development, QbD based optimization and pre-clinical evaluation

Diacerein (DCN) is a chondroprotective agent which shows inadequate oral bioavailability along with gastrointestinal side effects. This study is intended to develop a topical novel DCN delivery system. DCN nanogel was prepared by emulsion solvent diffusion technique. The formulation was optimized by...

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Veröffentlicht in:	Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2023-03, Vol.223, p.113160-113160, Article 113160
Hauptverfasser:	Kesharwani, Disha, Das Paul, Swarnali, Paliwal, Rishi, Satapathy, Trilochan
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Arthritis Bioavailability Diacerein Drug Carriers - chemistry Nanogel Nanogels Particle Size Polyethylene Glycols - chemistry QbD Topical
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