Antioxidants encapsulated milk-derived exosomes for functional food development
Reactive oxygen species are known to be involved in various diseases, and antioxidant ingredients are expected to essentially prevent diseases and contribute to improving health. However, antioxidants are easily degraded by enzymes before being absorbed in the intestine, so a means of transport that...
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Veröffentlicht in: | Analytical sciences 2023-05, Vol.39 (5), p.705-712 |
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creator | Onizuka, Yuhei Fujita, Kazuya Ide, Sachiko Naito, Toyohiro Kaji, Noritada |
description | Reactive oxygen species are known to be involved in various diseases, and antioxidant ingredients are expected to essentially prevent diseases and contribute to improving health. However, antioxidants are easily degraded by enzymes before being absorbed in the intestine, so a means of transport that prevents their degradation in the body is necessary. Exosomes, which play an important role in communication between individual cells, have attracted attention as a new transport carrier of miRNA and DNA, but not yet fully exploited in food research. More recently, exosomes extracted from bovine milk began to be widely used as a cost-effective transport carrier not in clinical medicine but also in functional food materials. To develop practical applications as carriers for functional foods, systematic studies are necessary to clarify the introduction efficiency and the properties of encapsulated substances. In this study, we applied electroporation and incubation to encapsulate antioxidants into the exosomes and studied the encapsulation efficiency into the exosomes and the anticancer activity.
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doi_str_mv | 10.1007/s44211-023-00278-9 |
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Graphical abstract</description><subject>Analytical Chemistry</subject><subject>Animals</subject><subject>Antioxidants - analysis</subject><subject>Antioxidants - pharmacology</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Exosomes - chemistry</subject><subject>Functional Food</subject><subject>MicroRNAs - analysis</subject><subject>Milk - chemistry</subject><subject>Special Issue: Original Paper</subject><issn>0910-6340</issn><issn>1348-2246</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kDtPwzAUhS0EoqXwBxhQRhaDX4ntsUK8JKQuMFuOfYNSkrjYSQX_HkMLI9PVOfecM3wInVNyRQmR10kIRikmjGNCmFRYH6A55UJhxkR1iOZEU4IrLsgMnaS0JoQyxdgxmvFKciWImKPVchjb8NF6O4ypgMHZTZo6O4Iv-rZ7wx5iu80CPkIKPaSiCbFopsHl1mC7LIMvPGyhC5sehvEUHTW2S3C2vwv0cnf7fPOAn1b3jzfLJ-wEL0dcK-F8SZpSlXUFgmvqak2zQaXTXhFGuGBWaltrmy2unKyo0wq8EMAk4wt0udvdxPA-QRpN3yYHXWcHCFMyTEpOWUkVzVG2i7oYUorQmE1sexs_DSXmG6TZgTQZpPkBaXQuXez3p7oH_1f5JZcDfBdI-TW8QjTrMMWMJP03-wVm3n6k</recordid><startdate>20230501</startdate><enddate>20230501</enddate><creator>Onizuka, Yuhei</creator><creator>Fujita, Kazuya</creator><creator>Ide, Sachiko</creator><creator>Naito, Toyohiro</creator><creator>Kaji, Noritada</creator><general>Springer Nature Singapore</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9828-873X</orcidid></search><sort><creationdate>20230501</creationdate><title>Antioxidants encapsulated milk-derived exosomes for functional food development</title><author>Onizuka, Yuhei ; Fujita, Kazuya ; Ide, Sachiko ; Naito, Toyohiro ; Kaji, Noritada</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-b84cd50f585b6e4391cb9150f17c9d8020342a79ab9a17c38c761c98ed44e2723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Analytical Chemistry</topic><topic>Animals</topic><topic>Antioxidants - analysis</topic><topic>Antioxidants - pharmacology</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Exosomes - chemistry</topic><topic>Functional Food</topic><topic>MicroRNAs - analysis</topic><topic>Milk - chemistry</topic><topic>Special Issue: Original Paper</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Onizuka, Yuhei</creatorcontrib><creatorcontrib>Fujita, Kazuya</creatorcontrib><creatorcontrib>Ide, Sachiko</creatorcontrib><creatorcontrib>Naito, Toyohiro</creatorcontrib><creatorcontrib>Kaji, Noritada</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Analytical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Onizuka, Yuhei</au><au>Fujita, Kazuya</au><au>Ide, Sachiko</au><au>Naito, Toyohiro</au><au>Kaji, Noritada</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antioxidants encapsulated milk-derived exosomes for functional food development</atitle><jtitle>Analytical sciences</jtitle><stitle>ANAL. SCI</stitle><addtitle>Anal Sci</addtitle><date>2023-05-01</date><risdate>2023</risdate><volume>39</volume><issue>5</issue><spage>705</spage><epage>712</epage><pages>705-712</pages><issn>0910-6340</issn><eissn>1348-2246</eissn><abstract>Reactive oxygen species are known to be involved in various diseases, and antioxidant ingredients are expected to essentially prevent diseases and contribute to improving health. However, antioxidants are easily degraded by enzymes before being absorbed in the intestine, so a means of transport that prevents their degradation in the body is necessary. Exosomes, which play an important role in communication between individual cells, have attracted attention as a new transport carrier of miRNA and DNA, but not yet fully exploited in food research. More recently, exosomes extracted from bovine milk began to be widely used as a cost-effective transport carrier not in clinical medicine but also in functional food materials. To develop practical applications as carriers for functional foods, systematic studies are necessary to clarify the introduction efficiency and the properties of encapsulated substances. In this study, we applied electroporation and incubation to encapsulate antioxidants into the exosomes and studied the encapsulation efficiency into the exosomes and the anticancer activity.
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subjects | Analytical Chemistry Animals Antioxidants - analysis Antioxidants - pharmacology Chemistry Chemistry and Materials Science Exosomes - chemistry Functional Food MicroRNAs - analysis Milk - chemistry Special Issue: Original Paper |
title | Antioxidants encapsulated milk-derived exosomes for functional food development |
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