Antioxidants encapsulated milk-derived exosomes for functional food development

Reactive oxygen species are known to be involved in various diseases, and antioxidant ingredients are expected to essentially prevent diseases and contribute to improving health. However, antioxidants are easily degraded by enzymes before being absorbed in the intestine, so a means of transport that...

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Veröffentlicht in:Analytical sciences 2023-05, Vol.39 (5), p.705-712
Hauptverfasser: Onizuka, Yuhei, Fujita, Kazuya, Ide, Sachiko, Naito, Toyohiro, Kaji, Noritada
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container_issue 5
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container_title Analytical sciences
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creator Onizuka, Yuhei
Fujita, Kazuya
Ide, Sachiko
Naito, Toyohiro
Kaji, Noritada
description Reactive oxygen species are known to be involved in various diseases, and antioxidant ingredients are expected to essentially prevent diseases and contribute to improving health. However, antioxidants are easily degraded by enzymes before being absorbed in the intestine, so a means of transport that prevents their degradation in the body is necessary. Exosomes, which play an important role in communication between individual cells, have attracted attention as a new transport carrier of miRNA and DNA, but not yet fully exploited in food research. More recently, exosomes extracted from bovine milk began to be widely used as a cost-effective transport carrier not in clinical medicine but also in functional food materials. To develop practical applications as carriers for functional foods, systematic studies are necessary to clarify the introduction efficiency and the properties of encapsulated substances. In this study, we applied electroporation and incubation to encapsulate antioxidants into the exosomes and studied the encapsulation efficiency into the exosomes and the anticancer activity. Graphical abstract
doi_str_mv 10.1007/s44211-023-00278-9
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source MEDLINE; Open Access Titles of Japan; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SpringerLink Journals - AutoHoldings
subjects Analytical Chemistry
Animals
Antioxidants - analysis
Antioxidants - pharmacology
Chemistry
Chemistry and Materials Science
Exosomes - chemistry
Functional Food
MicroRNAs - analysis
Milk - chemistry
Special Issue: Original Paper
title Antioxidants encapsulated milk-derived exosomes for functional food development
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