The mechanism of rh-endostatin-induced cardiotoxicity and its protection by dihydromyricetin[in vivo/in vitro, C57BL/6 mice, AC16 and hiPSC-CMs]

Recombinant human endostatin (rh-endostatin) is an anti-angiogenic drug, which is used for the treatment of advanced non-small-cell lung cancer (NSCLC) and other cancers. However, its side effects, especially the cardiotoxicity with unclear mechanisms limit its wide application in clinical practice....

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Veröffentlicht in:	Toxicology letters 2023-03, Vol.377, p.29-37
Hauptverfasser:	Guan, Xiaoran, Li, Wuquan, Wang, Yong, Zhao, Qun, Yu, Xinru, Jiang, Jing, Bian, Weihua, Xu, Cong, Sun, Yeying, Zhang, Chunxiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinoma, Non-Small-Cell Lung - metabolism Cardiotoxicity Drug-Related Side Effects and Adverse Reactions - metabolism Endostatins - metabolism Endostatins - toxicity Humans Induced Pluripotent Stem Cells Lung Neoplasms - metabolism Mechanism Mice Mice, Inbred C57BL Mitochondrial dysfunction Myocytes, Cardiac Recombinant human endostatin
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