Endothelial dysfunction predicts bleeding and cardiovascular death in acute coronary syndrome
Recently, there has been increasing awareness that bleeding may lead to adverse outcomes. Endothelial dysfunction is associated with increased risk of cardiovascular and bleeding events. This study aimed to investigate the association of endothelial dysfunction with major bleeding and specific cause...
Gespeichert in:
| Veröffentlicht in: | International journal of cardiology 2023-04, Vol.376, p.11-17 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 17 |
|---|---|
| container_issue | |
| container_start_page | 11 |
| container_title | International journal of cardiology |
| container_volume | 376 |
| creator | Yoshii, Tomohiro Matsuzawa, Yasushi Kato, So Sato, Ryosuke Hanajima, Youhei Kikuchi, Shinnosuke Nakahashi, Hidefumi Konishi, Masaaki Akiyama, Eiichi Minamimoto, Yugo Kimura, Yuichiro Okada, Kozo Maejima, Nobuhiko Iwahashi, Noriaki Ebina, Toshiaki Hibi, Kiyoshi Kosuge, Masami Misumi, Toshihiro Tamura, Kouichi Kimura, Kazuo |
| description | Recently, there has been increasing awareness that bleeding may lead to adverse outcomes. Endothelial dysfunction is associated with increased risk of cardiovascular and bleeding events. This study aimed to investigate the association of endothelial dysfunction with major bleeding and specific causes of death in addition to major adverse cardiovascular events in patients with acute coronary syndrome.
This single-centre retrospective observational study was conducted at a tertiary-care hospital; patients with acute coronary syndrome were included between June 2010 and November 2014 (median follow-up, 6.1 years). The reactive hyperaemia index was assessed before their discharge; reactive hyperaemia index |
| doi_str_mv | 10.1016/j.ijcard.2023.01.079 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2773116092</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0167527323001213</els_id><sourcerecordid>2773116092</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-6bbd47f1e93a6f387bc0a59a357fcc920a1f1415e78cbe6682660fbea8a3a3e3</originalsourceid><addsrcrecordid>eNp9kE1LxDAQhoMoun78A5EcvbQmTZu0F0HELxC8eJUwTaaapZusSSvsvzfLqkdPM4dn5p15CDnnrOSMy6tl6ZYGoi0rVomS8ZKpbo8seKvqgqum3ieLjKmiqZQ4IscpLRljdde1h-RISCWkVHxB3u68DdMHjg5GajdpmL2ZXPB0HdE6MyXaj5g7_07BW7oNdOELkplHiNQiTB_UeQpmnpCaEIOHuKFp420MKzwlBwOMCc9-6gl5vb97vX0snl8enm5vngtTq3oqZN_bWg0cOwFyEK3qDYOmA9GowZiuYsAHXvMGVWt6lLKtpGRDj9CCAIHihFzu1q5j-JwxTXrlksFxBI9hTrpSSnAuWVdltN6hJoaUIg56Hd0q36w501uveql3XvXWq2ZcZ6957OInYe5XaP-GfkVm4HoHYH7zy2HUyTj0JquLaCZtg_s_4RvNn41b</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2773116092</pqid></control><display><type>article</type><title>Endothelial dysfunction predicts bleeding and cardiovascular death in acute coronary syndrome</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Yoshii, Tomohiro ; Matsuzawa, Yasushi ; Kato, So ; Sato, Ryosuke ; Hanajima, Youhei ; Kikuchi, Shinnosuke ; Nakahashi, Hidefumi ; Konishi, Masaaki ; Akiyama, Eiichi ; Minamimoto, Yugo ; Kimura, Yuichiro ; Okada, Kozo ; Maejima, Nobuhiko ; Iwahashi, Noriaki ; Ebina, Toshiaki ; Hibi, Kiyoshi ; Kosuge, Masami ; Misumi, Toshihiro ; Tamura, Kouichi ; Kimura, Kazuo</creator><creatorcontrib>Yoshii, Tomohiro ; Matsuzawa, Yasushi ; Kato, So ; Sato, Ryosuke ; Hanajima, Youhei ; Kikuchi, Shinnosuke ; Nakahashi, Hidefumi ; Konishi, Masaaki ; Akiyama, Eiichi ; Minamimoto, Yugo ; Kimura, Yuichiro ; Okada, Kozo ; Maejima, Nobuhiko ; Iwahashi, Noriaki ; Ebina, Toshiaki ; Hibi, Kiyoshi ; Kosuge, Masami ; Misumi, Toshihiro ; Tamura, Kouichi ; Kimura, Kazuo</creatorcontrib><description>Recently, there has been increasing awareness that bleeding may lead to adverse outcomes. Endothelial dysfunction is associated with increased risk of cardiovascular and bleeding events. This study aimed to investigate the association of endothelial dysfunction with major bleeding and specific causes of death in addition to major adverse cardiovascular events in patients with acute coronary syndrome.
This single-centre retrospective observational study was conducted at a tertiary-care hospital; patients with acute coronary syndrome were included between June 2010 and November 2014 (median follow-up, 6.1 years). The reactive hyperaemia index was assessed before their discharge; reactive hyperaemia index <1.67 was defined as endothelial dysfunction. The main outcomes were the incidence of major bleeding, all-cause death, cardiovascular death, non-cardiovascular death, resuscitated cardiac arrest, non-fatal myocardial infarction, non-fatal stroke, and hospitalisation for heart failure.
Among the included 674 patients with acute coronary syndrome, 264 (39.2%) had endothelial dysfunction. Multivariable Cox-hazard analyses revealed an independent predictive value of endothelial dysfunction for major bleeding (hazard ratio 2.29, 95% confidence interval 1.17–4.48, P = 0.016) and major adverse cardiovascular events (hazard ratio 2.04, 95% confidence interval 1.43–2.89, P < 0.001). The endothelial dysfunction group patients had a 2.5-fold greater risk of cardiovascular death; however, no association was found with non-cardiovascular death.
Endothelial dysfunction assessed using reactive hyperaemia index predicted future major cardiovascular event as well as major bleeding and cardiovascular death in patients with acute coronary syndrome.
[Display omitted]
•Endothelial dysfunction (ED) was related to 2.5-fold higher cardiovascular mortality.•ED was associated with not only atherothrombotic but also bleeding events.•ED could be a comprehensive marker of vascular health.</description><identifier>ISSN: 0167-5273</identifier><identifier>EISSN: 1874-1754</identifier><identifier>DOI: 10.1016/j.ijcard.2023.01.079</identifier><identifier>PMID: 36736671</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Acute Coronary Syndrome ; Bleeding event ; Cardiovascular death ; Cardiovascular event ; Endothelial dysfunction ; Hemorrhage ; Humans ; Hyperemia ; Myocardial Infarction - epidemiology ; Stroke</subject><ispartof>International journal of cardiology, 2023-04, Vol.376, p.11-17</ispartof><rights>2023 Elsevier B.V.</rights><rights>Copyright © 2023 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-6bbd47f1e93a6f387bc0a59a357fcc920a1f1415e78cbe6682660fbea8a3a3e3</citedby><cites>FETCH-LOGICAL-c474t-6bbd47f1e93a6f387bc0a59a357fcc920a1f1415e78cbe6682660fbea8a3a3e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijcard.2023.01.079$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36736671$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yoshii, Tomohiro</creatorcontrib><creatorcontrib>Matsuzawa, Yasushi</creatorcontrib><creatorcontrib>Kato, So</creatorcontrib><creatorcontrib>Sato, Ryosuke</creatorcontrib><creatorcontrib>Hanajima, Youhei</creatorcontrib><creatorcontrib>Kikuchi, Shinnosuke</creatorcontrib><creatorcontrib>Nakahashi, Hidefumi</creatorcontrib><creatorcontrib>Konishi, Masaaki</creatorcontrib><creatorcontrib>Akiyama, Eiichi</creatorcontrib><creatorcontrib>Minamimoto, Yugo</creatorcontrib><creatorcontrib>Kimura, Yuichiro</creatorcontrib><creatorcontrib>Okada, Kozo</creatorcontrib><creatorcontrib>Maejima, Nobuhiko</creatorcontrib><creatorcontrib>Iwahashi, Noriaki</creatorcontrib><creatorcontrib>Ebina, Toshiaki</creatorcontrib><creatorcontrib>Hibi, Kiyoshi</creatorcontrib><creatorcontrib>Kosuge, Masami</creatorcontrib><creatorcontrib>Misumi, Toshihiro</creatorcontrib><creatorcontrib>Tamura, Kouichi</creatorcontrib><creatorcontrib>Kimura, Kazuo</creatorcontrib><title>Endothelial dysfunction predicts bleeding and cardiovascular death in acute coronary syndrome</title><title>International journal of cardiology</title><addtitle>Int J Cardiol</addtitle><description>Recently, there has been increasing awareness that bleeding may lead to adverse outcomes. Endothelial dysfunction is associated with increased risk of cardiovascular and bleeding events. This study aimed to investigate the association of endothelial dysfunction with major bleeding and specific causes of death in addition to major adverse cardiovascular events in patients with acute coronary syndrome.
This single-centre retrospective observational study was conducted at a tertiary-care hospital; patients with acute coronary syndrome were included between June 2010 and November 2014 (median follow-up, 6.1 years). The reactive hyperaemia index was assessed before their discharge; reactive hyperaemia index <1.67 was defined as endothelial dysfunction. The main outcomes were the incidence of major bleeding, all-cause death, cardiovascular death, non-cardiovascular death, resuscitated cardiac arrest, non-fatal myocardial infarction, non-fatal stroke, and hospitalisation for heart failure.
Among the included 674 patients with acute coronary syndrome, 264 (39.2%) had endothelial dysfunction. Multivariable Cox-hazard analyses revealed an independent predictive value of endothelial dysfunction for major bleeding (hazard ratio 2.29, 95% confidence interval 1.17–4.48, P = 0.016) and major adverse cardiovascular events (hazard ratio 2.04, 95% confidence interval 1.43–2.89, P < 0.001). The endothelial dysfunction group patients had a 2.5-fold greater risk of cardiovascular death; however, no association was found with non-cardiovascular death.
Endothelial dysfunction assessed using reactive hyperaemia index predicted future major cardiovascular event as well as major bleeding and cardiovascular death in patients with acute coronary syndrome.
[Display omitted]
•Endothelial dysfunction (ED) was related to 2.5-fold higher cardiovascular mortality.•ED was associated with not only atherothrombotic but also bleeding events.•ED could be a comprehensive marker of vascular health.</description><subject>Acute Coronary Syndrome</subject><subject>Bleeding event</subject><subject>Cardiovascular death</subject><subject>Cardiovascular event</subject><subject>Endothelial dysfunction</subject><subject>Hemorrhage</subject><subject>Humans</subject><subject>Hyperemia</subject><subject>Myocardial Infarction - epidemiology</subject><subject>Stroke</subject><issn>0167-5273</issn><issn>1874-1754</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMoun78A5EcvbQmTZu0F0HELxC8eJUwTaaapZusSSvsvzfLqkdPM4dn5p15CDnnrOSMy6tl6ZYGoi0rVomS8ZKpbo8seKvqgqum3ieLjKmiqZQ4IscpLRljdde1h-RISCWkVHxB3u68DdMHjg5GajdpmL2ZXPB0HdE6MyXaj5g7_07BW7oNdOELkplHiNQiTB_UeQpmnpCaEIOHuKFp420MKzwlBwOMCc9-6gl5vb97vX0snl8enm5vngtTq3oqZN_bWg0cOwFyEK3qDYOmA9GowZiuYsAHXvMGVWt6lLKtpGRDj9CCAIHihFzu1q5j-JwxTXrlksFxBI9hTrpSSnAuWVdltN6hJoaUIg56Hd0q36w501uveql3XvXWq2ZcZ6957OInYe5XaP-GfkVm4HoHYH7zy2HUyTj0JquLaCZtg_s_4RvNn41b</recordid><startdate>20230401</startdate><enddate>20230401</enddate><creator>Yoshii, Tomohiro</creator><creator>Matsuzawa, Yasushi</creator><creator>Kato, So</creator><creator>Sato, Ryosuke</creator><creator>Hanajima, Youhei</creator><creator>Kikuchi, Shinnosuke</creator><creator>Nakahashi, Hidefumi</creator><creator>Konishi, Masaaki</creator><creator>Akiyama, Eiichi</creator><creator>Minamimoto, Yugo</creator><creator>Kimura, Yuichiro</creator><creator>Okada, Kozo</creator><creator>Maejima, Nobuhiko</creator><creator>Iwahashi, Noriaki</creator><creator>Ebina, Toshiaki</creator><creator>Hibi, Kiyoshi</creator><creator>Kosuge, Masami</creator><creator>Misumi, Toshihiro</creator><creator>Tamura, Kouichi</creator><creator>Kimura, Kazuo</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20230401</creationdate><title>Endothelial dysfunction predicts bleeding and cardiovascular death in acute coronary syndrome</title><author>Yoshii, Tomohiro ; Matsuzawa, Yasushi ; Kato, So ; Sato, Ryosuke ; Hanajima, Youhei ; Kikuchi, Shinnosuke ; Nakahashi, Hidefumi ; Konishi, Masaaki ; Akiyama, Eiichi ; Minamimoto, Yugo ; Kimura, Yuichiro ; Okada, Kozo ; Maejima, Nobuhiko ; Iwahashi, Noriaki ; Ebina, Toshiaki ; Hibi, Kiyoshi ; Kosuge, Masami ; Misumi, Toshihiro ; Tamura, Kouichi ; Kimura, Kazuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-6bbd47f1e93a6f387bc0a59a357fcc920a1f1415e78cbe6682660fbea8a3a3e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Acute Coronary Syndrome</topic><topic>Bleeding event</topic><topic>Cardiovascular death</topic><topic>Cardiovascular event</topic><topic>Endothelial dysfunction</topic><topic>Hemorrhage</topic><topic>Humans</topic><topic>Hyperemia</topic><topic>Myocardial Infarction - epidemiology</topic><topic>Stroke</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yoshii, Tomohiro</creatorcontrib><creatorcontrib>Matsuzawa, Yasushi</creatorcontrib><creatorcontrib>Kato, So</creatorcontrib><creatorcontrib>Sato, Ryosuke</creatorcontrib><creatorcontrib>Hanajima, Youhei</creatorcontrib><creatorcontrib>Kikuchi, Shinnosuke</creatorcontrib><creatorcontrib>Nakahashi, Hidefumi</creatorcontrib><creatorcontrib>Konishi, Masaaki</creatorcontrib><creatorcontrib>Akiyama, Eiichi</creatorcontrib><creatorcontrib>Minamimoto, Yugo</creatorcontrib><creatorcontrib>Kimura, Yuichiro</creatorcontrib><creatorcontrib>Okada, Kozo</creatorcontrib><creatorcontrib>Maejima, Nobuhiko</creatorcontrib><creatorcontrib>Iwahashi, Noriaki</creatorcontrib><creatorcontrib>Ebina, Toshiaki</creatorcontrib><creatorcontrib>Hibi, Kiyoshi</creatorcontrib><creatorcontrib>Kosuge, Masami</creatorcontrib><creatorcontrib>Misumi, Toshihiro</creatorcontrib><creatorcontrib>Tamura, Kouichi</creatorcontrib><creatorcontrib>Kimura, Kazuo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yoshii, Tomohiro</au><au>Matsuzawa, Yasushi</au><au>Kato, So</au><au>Sato, Ryosuke</au><au>Hanajima, Youhei</au><au>Kikuchi, Shinnosuke</au><au>Nakahashi, Hidefumi</au><au>Konishi, Masaaki</au><au>Akiyama, Eiichi</au><au>Minamimoto, Yugo</au><au>Kimura, Yuichiro</au><au>Okada, Kozo</au><au>Maejima, Nobuhiko</au><au>Iwahashi, Noriaki</au><au>Ebina, Toshiaki</au><au>Hibi, Kiyoshi</au><au>Kosuge, Masami</au><au>Misumi, Toshihiro</au><au>Tamura, Kouichi</au><au>Kimura, Kazuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endothelial dysfunction predicts bleeding and cardiovascular death in acute coronary syndrome</atitle><jtitle>International journal of cardiology</jtitle><addtitle>Int J Cardiol</addtitle><date>2023-04-01</date><risdate>2023</risdate><volume>376</volume><spage>11</spage><epage>17</epage><pages>11-17</pages><issn>0167-5273</issn><eissn>1874-1754</eissn><abstract>Recently, there has been increasing awareness that bleeding may lead to adverse outcomes. Endothelial dysfunction is associated with increased risk of cardiovascular and bleeding events. This study aimed to investigate the association of endothelial dysfunction with major bleeding and specific causes of death in addition to major adverse cardiovascular events in patients with acute coronary syndrome.
This single-centre retrospective observational study was conducted at a tertiary-care hospital; patients with acute coronary syndrome were included between June 2010 and November 2014 (median follow-up, 6.1 years). The reactive hyperaemia index was assessed before their discharge; reactive hyperaemia index <1.67 was defined as endothelial dysfunction. The main outcomes were the incidence of major bleeding, all-cause death, cardiovascular death, non-cardiovascular death, resuscitated cardiac arrest, non-fatal myocardial infarction, non-fatal stroke, and hospitalisation for heart failure.
Among the included 674 patients with acute coronary syndrome, 264 (39.2%) had endothelial dysfunction. Multivariable Cox-hazard analyses revealed an independent predictive value of endothelial dysfunction for major bleeding (hazard ratio 2.29, 95% confidence interval 1.17–4.48, P = 0.016) and major adverse cardiovascular events (hazard ratio 2.04, 95% confidence interval 1.43–2.89, P < 0.001). The endothelial dysfunction group patients had a 2.5-fold greater risk of cardiovascular death; however, no association was found with non-cardiovascular death.
Endothelial dysfunction assessed using reactive hyperaemia index predicted future major cardiovascular event as well as major bleeding and cardiovascular death in patients with acute coronary syndrome.
[Display omitted]
•Endothelial dysfunction (ED) was related to 2.5-fold higher cardiovascular mortality.•ED was associated with not only atherothrombotic but also bleeding events.•ED could be a comprehensive marker of vascular health.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>36736671</pmid><doi>10.1016/j.ijcard.2023.01.079</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0167-5273 |
| ispartof | International journal of cardiology, 2023-04, Vol.376, p.11-17 |
| issn | 0167-5273 1874-1754 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2773116092 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Acute Coronary Syndrome Bleeding event Cardiovascular death Cardiovascular event Endothelial dysfunction Hemorrhage Humans Hyperemia Myocardial Infarction - epidemiology Stroke |
| title | Endothelial dysfunction predicts bleeding and cardiovascular death in acute coronary syndrome |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T03%3A23%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Endothelial%20dysfunction%20predicts%20bleeding%20and%20cardiovascular%20death%20in%20acute%20coronary%20syndrome&rft.jtitle=International%20journal%20of%20cardiology&rft.au=Yoshii,%20Tomohiro&rft.date=2023-04-01&rft.volume=376&rft.spage=11&rft.epage=17&rft.pages=11-17&rft.issn=0167-5273&rft.eissn=1874-1754&rft_id=info:doi/10.1016/j.ijcard.2023.01.079&rft_dat=%3Cproquest_cross%3E2773116092%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2773116092&rft_id=info:pmid/36736671&rft_els_id=S0167527323001213&rfr_iscdi=true |