The regulatory roles of socio‐economic status, social and intellectual activity in the relationship between alcohol consumption and cognitive decline trajectory in middle‐aged and elderly Chinese: A prospective cohort study
Objectives To determine the relationship between alcohol consumption and cognitive decline, and to further explore the potential regulatory role of education, socio‐economic status (SES), and social or intellectual activity in this relationship. Methods 6197 participants aged 45–75 years with four r...
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| Veröffentlicht in: | International journal of geriatric psychiatry 2023-02, Vol.38 (2), p.e5877-n/a |
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| creator | Cheng, Fang Ju, Yanli Chen, Xueyu Jia, Hongying |
| description | Objectives
To determine the relationship between alcohol consumption and cognitive decline, and to further explore the potential regulatory role of education, socio‐economic status (SES), and social or intellectual activity in this relationship.
Methods
6197 participants aged 45–75 years with four repeated measures data from 2011 to 2018 were included. A mixed‐effect model was used to explore the relationship between alcohol consumption and the rate of change in cognitive decline, a latent class growth mixed model (LCGMM) was applied to determine the potential trajectory of cognitive decline, and finally, the mediating and moderating analyses were used to determine the regulatory effect of all four variables on the relationship between alcohol consumption and potential trajectory.
Results
Compared to never‐drinkers, moderate alcohol consumption was a protective factor for overall cognitive function (β = 0.13, 95% CI: 0.04–0.20, p |
| doi_str_mv | 10.1002/gps.5877 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2773114691</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2773114691</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3497-27da1f6ab120041409351202e40a28b1aae1c16087e520e9b1e43cf8a105b99b3</originalsourceid><addsrcrecordid>eNp1kc9u1DAQhy0EoktB4gmQJS4cSPE4_7lVKyhIlUCinCPHmd31yomD7VDlxiP0GcuLMEkLSEicbHm--fyzh7HnIM5ACPlmP4azvCrLB2wDoq4TgKJ4yDaiqvKkkKk4YU9COApBNages5O0KNMMCrlhP68OyD3uJ6ui8zP3zmLgbseD08bd_rhB7QbXG81DVHEKr9eCslwNHTdDRGtRx2k50NF8N3GmUx5XKSmNG8LBjLzFeI04cGW1OzjLSRqmflzqq0m7_WCoH3mH2poBefTqSOYlEwl703UWKY7aY7d2oO3Q25lvD0QHfMvP-ehdGFGvmuUaHyn01M1P2aOdsgGf3a-n7Ov7d1fbD8nlp4uP2_PLRKdZXSay7BTsCtWCFCKDTNRpTluJmVCyakEpBA2FqErMpcC6BcxSvasUiLyt6zY9Za_uvBTk24QhNr0Jmn5IDeim0MiyTAGyogZCX_6DHt3kB0q3UHVa5rKq_go1vSx43DWjN73ycwOiWQbf0OCbZfCEvrgXTm2P3R_w96QJSO6Aa2Nx_q-oufj8ZRX-Aoekvqc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2779375288</pqid></control><display><type>article</type><title>The regulatory roles of socio‐economic status, social and intellectual activity in the relationship between alcohol consumption and cognitive decline trajectory in middle‐aged and elderly Chinese: A prospective cohort study</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Cheng, Fang ; Ju, Yanli ; Chen, Xueyu ; Jia, Hongying</creator><creatorcontrib>Cheng, Fang ; Ju, Yanli ; Chen, Xueyu ; Jia, Hongying</creatorcontrib><description><![CDATA[Objectives
To determine the relationship between alcohol consumption and cognitive decline, and to further explore the potential regulatory role of education, socio‐economic status (SES), and social or intellectual activity in this relationship.
Methods
6197 participants aged 45–75 years with four repeated measures data from 2011 to 2018 were included. A mixed‐effect model was used to explore the relationship between alcohol consumption and the rate of change in cognitive decline, a latent class growth mixed model (LCGMM) was applied to determine the potential trajectory of cognitive decline, and finally, the mediating and moderating analyses were used to determine the regulatory effect of all four variables on the relationship between alcohol consumption and potential trajectory.
Results
Compared to never‐drinkers, moderate alcohol consumption was a protective factor for overall cognitive function (β = 0.13, 95% CI: 0.04–0.20, p < 0.001), but there was no statistical correlation with the decline rate of cognitive function. And this protective effect was no longer significant after additional adjustments for education, SES, social and intellectual activity. The LCGMM model divided participants into two trajectories, a high‐level‐to‐decline group including 79.75% of participants (quadratic: β [SE]: −0.90 [0.07], p < 0.001), and a low‐level‐to‐decline group including 20.25% participants (linear: β [SE]: −3.05 [0.49], p < 0.001). With the latter as the reference, SES played a reverse regulation role in the harmful effect of heavy drinking on cognitive trajectories (odd ratio [OR] = 0.46, 95% CI: 0.23–0.93, p < 0.05). Social and intellectual activities played a negative mediating role in the harmful effect of alcohol consumption on cognitive trajectories (light: OR = 0.96, p < 0.001; moderate: OR = 0.96, p < 0.001; heavy: OR = 0.97, p < 0.01).
Conclusions
Alcohol itself has no protective effect on the decline of longitudinal cognitive trajectory. But the regulatory effect of SES, social and intellectual activities slows down the harm of alcohol consumption on the decline of cognitive function.
Clinical Trial Registration
The data used in this study are from publicly available databases. They are retrospective cohort studies without any intervention. Therefore, no clinical trial registration has been conducted.
Key points
Previous results on the association between alcohol consumption and cognitive function are inconsistent, and the role of socio‐economic status (SES), social and intellectual activities in this association has not been explored.
In this study of 6197 Chinese people aged 45–75, it was observed that drinking is a risk factor for the decline of the longitudinal cognitive trajectory, and the negative regulatory effects of SES, social and intellectual activities slows down the harm of alcohol consumption on the decline of cognitive function.]]></description><identifier>ISSN: 0885-6230</identifier><identifier>EISSN: 1099-1166</identifier><identifier>DOI: 10.1002/gps.5877</identifier><identifier>PMID: 36734162</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Aged ; Alcohol ; alcohol consumption ; Alcohol Drinking - adverse effects ; Alcohol Drinking - epidemiology ; Alcohol Drinking - psychology ; Alcohol use ; Clinical trials ; Cognitive ability ; Cognitive Dysfunction - epidemiology ; cognitive function ; Cohort analysis ; Drinking behavior ; East Asian People ; Economic Status ; Geriatric psychiatry ; Humans ; intellectual activity ; Middle Aged ; Older people ; Prospective Studies ; Retrospective Studies ; social activity ; socio‐economic status</subject><ispartof>International journal of geriatric psychiatry, 2023-02, Vol.38 (2), p.e5877-n/a</ispartof><rights>2023 John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3497-27da1f6ab120041409351202e40a28b1aae1c16087e520e9b1e43cf8a105b99b3</citedby><cites>FETCH-LOGICAL-c3497-27da1f6ab120041409351202e40a28b1aae1c16087e520e9b1e43cf8a105b99b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fgps.5877$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fgps.5877$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36734162$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheng, Fang</creatorcontrib><creatorcontrib>Ju, Yanli</creatorcontrib><creatorcontrib>Chen, Xueyu</creatorcontrib><creatorcontrib>Jia, Hongying</creatorcontrib><title>The regulatory roles of socio‐economic status, social and intellectual activity in the relationship between alcohol consumption and cognitive decline trajectory in middle‐aged and elderly Chinese: A prospective cohort study</title><title>International journal of geriatric psychiatry</title><addtitle>Int J Geriatr Psychiatry</addtitle><description><![CDATA[Objectives
To determine the relationship between alcohol consumption and cognitive decline, and to further explore the potential regulatory role of education, socio‐economic status (SES), and social or intellectual activity in this relationship.
Methods
6197 participants aged 45–75 years with four repeated measures data from 2011 to 2018 were included. A mixed‐effect model was used to explore the relationship between alcohol consumption and the rate of change in cognitive decline, a latent class growth mixed model (LCGMM) was applied to determine the potential trajectory of cognitive decline, and finally, the mediating and moderating analyses were used to determine the regulatory effect of all four variables on the relationship between alcohol consumption and potential trajectory.
Results
Compared to never‐drinkers, moderate alcohol consumption was a protective factor for overall cognitive function (β = 0.13, 95% CI: 0.04–0.20, p < 0.001), but there was no statistical correlation with the decline rate of cognitive function. And this protective effect was no longer significant after additional adjustments for education, SES, social and intellectual activity. The LCGMM model divided participants into two trajectories, a high‐level‐to‐decline group including 79.75% of participants (quadratic: β [SE]: −0.90 [0.07], p < 0.001), and a low‐level‐to‐decline group including 20.25% participants (linear: β [SE]: −3.05 [0.49], p < 0.001). With the latter as the reference, SES played a reverse regulation role in the harmful effect of heavy drinking on cognitive trajectories (odd ratio [OR] = 0.46, 95% CI: 0.23–0.93, p < 0.05). Social and intellectual activities played a negative mediating role in the harmful effect of alcohol consumption on cognitive trajectories (light: OR = 0.96, p < 0.001; moderate: OR = 0.96, p < 0.001; heavy: OR = 0.97, p < 0.01).
Conclusions
Alcohol itself has no protective effect on the decline of longitudinal cognitive trajectory. But the regulatory effect of SES, social and intellectual activities slows down the harm of alcohol consumption on the decline of cognitive function.
Clinical Trial Registration
The data used in this study are from publicly available databases. They are retrospective cohort studies without any intervention. Therefore, no clinical trial registration has been conducted.
Key points
Previous results on the association between alcohol consumption and cognitive function are inconsistent, and the role of socio‐economic status (SES), social and intellectual activities in this association has not been explored.
In this study of 6197 Chinese people aged 45–75, it was observed that drinking is a risk factor for the decline of the longitudinal cognitive trajectory, and the negative regulatory effects of SES, social and intellectual activities slows down the harm of alcohol consumption on the decline of cognitive function.]]></description><subject>Aged</subject><subject>Alcohol</subject><subject>alcohol consumption</subject><subject>Alcohol Drinking - adverse effects</subject><subject>Alcohol Drinking - epidemiology</subject><subject>Alcohol Drinking - psychology</subject><subject>Alcohol use</subject><subject>Clinical trials</subject><subject>Cognitive ability</subject><subject>Cognitive Dysfunction - epidemiology</subject><subject>cognitive function</subject><subject>Cohort analysis</subject><subject>Drinking behavior</subject><subject>East Asian People</subject><subject>Economic Status</subject><subject>Geriatric psychiatry</subject><subject>Humans</subject><subject>intellectual activity</subject><subject>Middle Aged</subject><subject>Older people</subject><subject>Prospective Studies</subject><subject>Retrospective Studies</subject><subject>social activity</subject><subject>socio‐economic status</subject><issn>0885-6230</issn><issn>1099-1166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc9u1DAQhy0EoktB4gmQJS4cSPE4_7lVKyhIlUCinCPHmd31yomD7VDlxiP0GcuLMEkLSEicbHm--fyzh7HnIM5ACPlmP4azvCrLB2wDoq4TgKJ4yDaiqvKkkKk4YU9COApBNages5O0KNMMCrlhP68OyD3uJ6ui8zP3zmLgbseD08bd_rhB7QbXG81DVHEKr9eCslwNHTdDRGtRx2k50NF8N3GmUx5XKSmNG8LBjLzFeI04cGW1OzjLSRqmflzqq0m7_WCoH3mH2poBefTqSOYlEwl703UWKY7aY7d2oO3Q25lvD0QHfMvP-ehdGFGvmuUaHyn01M1P2aOdsgGf3a-n7Ov7d1fbD8nlp4uP2_PLRKdZXSay7BTsCtWCFCKDTNRpTluJmVCyakEpBA2FqErMpcC6BcxSvasUiLyt6zY9Za_uvBTk24QhNr0Jmn5IDeim0MiyTAGyogZCX_6DHt3kB0q3UHVa5rKq_go1vSx43DWjN73ycwOiWQbf0OCbZfCEvrgXTm2P3R_w96QJSO6Aa2Nx_q-oufj8ZRX-Aoekvqc</recordid><startdate>202302</startdate><enddate>202302</enddate><creator>Cheng, Fang</creator><creator>Ju, Yanli</creator><creator>Chen, Xueyu</creator><creator>Jia, Hongying</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>202302</creationdate><title>The regulatory roles of socio‐economic status, social and intellectual activity in the relationship between alcohol consumption and cognitive decline trajectory in middle‐aged and elderly Chinese: A prospective cohort study</title><author>Cheng, Fang ; Ju, Yanli ; Chen, Xueyu ; Jia, Hongying</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3497-27da1f6ab120041409351202e40a28b1aae1c16087e520e9b1e43cf8a105b99b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Aged</topic><topic>Alcohol</topic><topic>alcohol consumption</topic><topic>Alcohol Drinking - adverse effects</topic><topic>Alcohol Drinking - epidemiology</topic><topic>Alcohol Drinking - psychology</topic><topic>Alcohol use</topic><topic>Clinical trials</topic><topic>Cognitive ability</topic><topic>Cognitive Dysfunction - epidemiology</topic><topic>cognitive function</topic><topic>Cohort analysis</topic><topic>Drinking behavior</topic><topic>East Asian People</topic><topic>Economic Status</topic><topic>Geriatric psychiatry</topic><topic>Humans</topic><topic>intellectual activity</topic><topic>Middle Aged</topic><topic>Older people</topic><topic>Prospective Studies</topic><topic>Retrospective Studies</topic><topic>social activity</topic><topic>socio‐economic status</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheng, Fang</creatorcontrib><creatorcontrib>Ju, Yanli</creatorcontrib><creatorcontrib>Chen, Xueyu</creatorcontrib><creatorcontrib>Jia, Hongying</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of geriatric psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheng, Fang</au><au>Ju, Yanli</au><au>Chen, Xueyu</au><au>Jia, Hongying</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The regulatory roles of socio‐economic status, social and intellectual activity in the relationship between alcohol consumption and cognitive decline trajectory in middle‐aged and elderly Chinese: A prospective cohort study</atitle><jtitle>International journal of geriatric psychiatry</jtitle><addtitle>Int J Geriatr Psychiatry</addtitle><date>2023-02</date><risdate>2023</risdate><volume>38</volume><issue>2</issue><spage>e5877</spage><epage>n/a</epage><pages>e5877-n/a</pages><issn>0885-6230</issn><eissn>1099-1166</eissn><abstract><![CDATA[Objectives
To determine the relationship between alcohol consumption and cognitive decline, and to further explore the potential regulatory role of education, socio‐economic status (SES), and social or intellectual activity in this relationship.
Methods
6197 participants aged 45–75 years with four repeated measures data from 2011 to 2018 were included. A mixed‐effect model was used to explore the relationship between alcohol consumption and the rate of change in cognitive decline, a latent class growth mixed model (LCGMM) was applied to determine the potential trajectory of cognitive decline, and finally, the mediating and moderating analyses were used to determine the regulatory effect of all four variables on the relationship between alcohol consumption and potential trajectory.
Results
Compared to never‐drinkers, moderate alcohol consumption was a protective factor for overall cognitive function (β = 0.13, 95% CI: 0.04–0.20, p < 0.001), but there was no statistical correlation with the decline rate of cognitive function. And this protective effect was no longer significant after additional adjustments for education, SES, social and intellectual activity. The LCGMM model divided participants into two trajectories, a high‐level‐to‐decline group including 79.75% of participants (quadratic: β [SE]: −0.90 [0.07], p < 0.001), and a low‐level‐to‐decline group including 20.25% participants (linear: β [SE]: −3.05 [0.49], p < 0.001). With the latter as the reference, SES played a reverse regulation role in the harmful effect of heavy drinking on cognitive trajectories (odd ratio [OR] = 0.46, 95% CI: 0.23–0.93, p < 0.05). Social and intellectual activities played a negative mediating role in the harmful effect of alcohol consumption on cognitive trajectories (light: OR = 0.96, p < 0.001; moderate: OR = 0.96, p < 0.001; heavy: OR = 0.97, p < 0.01).
Conclusions
Alcohol itself has no protective effect on the decline of longitudinal cognitive trajectory. But the regulatory effect of SES, social and intellectual activities slows down the harm of alcohol consumption on the decline of cognitive function.
Clinical Trial Registration
The data used in this study are from publicly available databases. They are retrospective cohort studies without any intervention. Therefore, no clinical trial registration has been conducted.
Key points
Previous results on the association between alcohol consumption and cognitive function are inconsistent, and the role of socio‐economic status (SES), social and intellectual activities in this association has not been explored.
In this study of 6197 Chinese people aged 45–75, it was observed that drinking is a risk factor for the decline of the longitudinal cognitive trajectory, and the negative regulatory effects of SES, social and intellectual activities slows down the harm of alcohol consumption on the decline of cognitive function.]]></abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>36734162</pmid><doi>10.1002/gps.5877</doi><tpages>11</tpages></addata></record> |
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| subjects | Aged Alcohol alcohol consumption Alcohol Drinking - adverse effects Alcohol Drinking - epidemiology Alcohol Drinking - psychology Alcohol use Clinical trials Cognitive ability Cognitive Dysfunction - epidemiology cognitive function Cohort analysis Drinking behavior East Asian People Economic Status Geriatric psychiatry Humans intellectual activity Middle Aged Older people Prospective Studies Retrospective Studies social activity socio‐economic status |
| title | The regulatory roles of socio‐economic status, social and intellectual activity in the relationship between alcohol consumption and cognitive decline trajectory in middle‐aged and elderly Chinese: A prospective cohort study |
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