Next-generation sequencing-based HLA typing reveals the association of HLA-B46:01:01 and HLA-DRB109:01:02 alleles with carbamazepine-induced hypersensitivity reactions in Vietnamese patients with epilepsy

Several studies have reported an association between certain human leukocyte antigen (HLA) alleles and carbamazepine (CBZ)-induced hypersensitivity reactions in patients with epilepsy. Here, the relationship between the clinical spectrum and the HLA allele profiles in patients with CBZ-induced hyper...

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Veröffentlicht in:	Human immunology 2023-03, Vol.84 (3), p.186-195
Hauptverfasser:	Bui, Thao Phuong, Nguyen, Linh Thi Tu, Le, Phuong Lan, Le, Nhan Thi Thanh, Nguyen, Thuy Doan, Van Nguyen, Lieu, Van Nguyen, Anh Thi, Trinh, Thai Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Anticonvulsants - adverse effects Carbamazepine Carbamazepine - adverse effects Drug Hypersensitivity - genetics Epilepsy Epilepsy - drug therapy High-Throughput Nucleotide Sequencing Histocompatibility Testing HLA-B Antigens - genetics HLA-B46:01:01 HLA-DRB1 Chains - genetics HLA-DRB109:01:02 Humans Hypersensitivity Southeast Asian People
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