Dermaplaning for Transdermal Drug Permeation Enhancement: A Qualitative and Quantitative Assessment
In this study, we sought to investigate the effect of dermaplaning, a popular cosmeceutical skin rejuvenation technique on the permeation of drugs. Baclofen and diclofenac were used as hydrophilic and hydrophobic model drugs, respectively. A specific area of skin was treated with 4 strokes of a derm...
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| Veröffentlicht in: | AAPS PharmSciTech 2023-02, Vol.24 (2), p.54-54, Article 54 |
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| creator | Tijani, Akeemat O. Frempong, Dorcas Kaur, Jagroop Sergent, Sophia Shaw, Kara Lessaint, Rebecca Al Shawi, Maryam Verana, Gabrielle Puri, Ashana |
| description | In this study, we sought to investigate the effect of dermaplaning, a popular cosmeceutical skin rejuvenation technique on the permeation of drugs. Baclofen and diclofenac were used as hydrophilic and hydrophobic model drugs, respectively. A specific area of skin was treated with 4 strokes of a dermaplane device. Interindividual variability was assessed by having multiple users operate the device for the study. Dermaplaned skin was histologically evaluated and characterized for resistance drop and the depletion of the stratum corneum (SC). The effect of dermaplaning on drug permeation was investigated via
in vitro
permeation studies. Histology studies depicted the removal of SC and some parts of viable epidermis by dermaplaning. A significant drop in electrical resistance post skin dermaplaning was observed for all treatment groups, signifying the depletion of barrier properties of SC (
p
|
| doi_str_mv | 10.1208/s12249-023-02505-y |
| format | Article |
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in vitro
permeation studies. Histology studies depicted the removal of SC and some parts of viable epidermis by dermaplaning. A significant drop in electrical resistance post skin dermaplaning was observed for all treatment groups, signifying the depletion of barrier properties of SC (
p
< 0.05). Consequently, significant drug flux and permeation were observed over 24 h for the model drugs across dermaplaned skin. However, varied absorption profile was observed
in vitro
for both drugs across dermaplaned skin. Dermaplaning displayed a better suitability for significantly enhancing the permeation of the hydrophilic drug, baclofen. Evidence of variation in results post dermaplaning was observed amidst multiple users as well (
p
< 0.05).
Graphical Abstract</description><identifier>ISSN: 1530-9932</identifier><identifier>EISSN: 1530-9932</identifier><identifier>DOI: 10.1208/s12249-023-02505-y</identifier><identifier>PMID: 36725790</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Administration, Cutaneous ; Baclofen - analysis ; Baclofen - metabolism ; Baclofen - pharmacology ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Biotechnology ; Epidermis - metabolism ; Pharmacology/Toxicology ; Pharmacy ; Research Article ; Skin - metabolism ; Skin Absorption</subject><ispartof>AAPS PharmSciTech, 2023-02, Vol.24 (2), p.54-54, Article 54</ispartof><rights>The Author(s), under exclusive licence to American Association of Pharmaceutical Scientists 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to American Association of Pharmaceutical Scientists.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c277t-d971798d4a3bef325e066864f39557c94a88b3ec2141a24b0b3eb6566ea8e48e3</citedby><cites>FETCH-LOGICAL-c277t-d971798d4a3bef325e066864f39557c94a88b3ec2141a24b0b3eb6566ea8e48e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1208/s12249-023-02505-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1208/s12249-023-02505-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36725790$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tijani, Akeemat O.</creatorcontrib><creatorcontrib>Frempong, Dorcas</creatorcontrib><creatorcontrib>Kaur, Jagroop</creatorcontrib><creatorcontrib>Sergent, Sophia</creatorcontrib><creatorcontrib>Shaw, Kara</creatorcontrib><creatorcontrib>Lessaint, Rebecca</creatorcontrib><creatorcontrib>Al Shawi, Maryam</creatorcontrib><creatorcontrib>Verana, Gabrielle</creatorcontrib><creatorcontrib>Puri, Ashana</creatorcontrib><title>Dermaplaning for Transdermal Drug Permeation Enhancement: A Qualitative and Quantitative Assessment</title><title>AAPS PharmSciTech</title><addtitle>AAPS PharmSciTech</addtitle><addtitle>AAPS PharmSciTech</addtitle><description>In this study, we sought to investigate the effect of dermaplaning, a popular cosmeceutical skin rejuvenation technique on the permeation of drugs. Baclofen and diclofenac were used as hydrophilic and hydrophobic model drugs, respectively. A specific area of skin was treated with 4 strokes of a dermaplane device. Interindividual variability was assessed by having multiple users operate the device for the study. Dermaplaned skin was histologically evaluated and characterized for resistance drop and the depletion of the stratum corneum (SC). The effect of dermaplaning on drug permeation was investigated via
in vitro
permeation studies. Histology studies depicted the removal of SC and some parts of viable epidermis by dermaplaning. A significant drop in electrical resistance post skin dermaplaning was observed for all treatment groups, signifying the depletion of barrier properties of SC (
p
< 0.05). Consequently, significant drug flux and permeation were observed over 24 h for the model drugs across dermaplaned skin. However, varied absorption profile was observed
in vitro
for both drugs across dermaplaned skin. Dermaplaning displayed a better suitability for significantly enhancing the permeation of the hydrophilic drug, baclofen. Evidence of variation in results post dermaplaning was observed amidst multiple users as well (
p
< 0.05).
Graphical Abstract</description><subject>Administration, Cutaneous</subject><subject>Baclofen - analysis</subject><subject>Baclofen - metabolism</subject><subject>Baclofen - pharmacology</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Biotechnology</subject><subject>Epidermis - metabolism</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><subject>Research Article</subject><subject>Skin - metabolism</subject><subject>Skin Absorption</subject><issn>1530-9932</issn><issn>1530-9932</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOwzAQRS0EoqXwAyyQl2wCfiYxu4qWh1QJkMracpJJSZU4xU6Q-ve4pEWsWFiex5k7movQJSU3lJH01lPGhIoI4-FJIqPtERpTyUmkFGfHf-IROvN-TQJJFT9FIx4nTCaKjFE-A9eYTW1sZVe4bB1eOmN9savWeOb6FX4NMZiuai2e2w9jc2jAdnd4it96U1ddaH0BNrbY5bY7FKbeg_c79BydlKb2cLH_J-j9Yb68f4oWL4_P99NFlLMk6aJCJTRRaSEMz6DkTAKJ4zQWJVdSJrkSJk0zDjmjghomMhKSLJZxDCYFkQKfoOtBd-Pazx58p5vK51CH46DtvQ5bqBKMERVQNqC5a713UOqNqxrjtpoSvTNXD-bqYJn-MVdvw9DVXr_PGih-Rw5uBoAPgA8tuwKn123vbLj5P9lvIJaGWw</recordid><startdate>20230201</startdate><enddate>20230201</enddate><creator>Tijani, Akeemat O.</creator><creator>Frempong, Dorcas</creator><creator>Kaur, Jagroop</creator><creator>Sergent, Sophia</creator><creator>Shaw, Kara</creator><creator>Lessaint, Rebecca</creator><creator>Al Shawi, Maryam</creator><creator>Verana, Gabrielle</creator><creator>Puri, Ashana</creator><general>Springer International Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20230201</creationdate><title>Dermaplaning for Transdermal Drug Permeation Enhancement: A Qualitative and Quantitative Assessment</title><author>Tijani, Akeemat O. ; Frempong, Dorcas ; Kaur, Jagroop ; Sergent, Sophia ; Shaw, Kara ; Lessaint, Rebecca ; Al Shawi, Maryam ; Verana, Gabrielle ; Puri, Ashana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c277t-d971798d4a3bef325e066864f39557c94a88b3ec2141a24b0b3eb6566ea8e48e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Administration, Cutaneous</topic><topic>Baclofen - analysis</topic><topic>Baclofen - metabolism</topic><topic>Baclofen - pharmacology</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Biotechnology</topic><topic>Epidermis - metabolism</topic><topic>Pharmacology/Toxicology</topic><topic>Pharmacy</topic><topic>Research Article</topic><topic>Skin - metabolism</topic><topic>Skin Absorption</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tijani, Akeemat O.</creatorcontrib><creatorcontrib>Frempong, Dorcas</creatorcontrib><creatorcontrib>Kaur, Jagroop</creatorcontrib><creatorcontrib>Sergent, Sophia</creatorcontrib><creatorcontrib>Shaw, Kara</creatorcontrib><creatorcontrib>Lessaint, Rebecca</creatorcontrib><creatorcontrib>Al Shawi, Maryam</creatorcontrib><creatorcontrib>Verana, Gabrielle</creatorcontrib><creatorcontrib>Puri, Ashana</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>AAPS PharmSciTech</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tijani, Akeemat O.</au><au>Frempong, Dorcas</au><au>Kaur, Jagroop</au><au>Sergent, Sophia</au><au>Shaw, Kara</au><au>Lessaint, Rebecca</au><au>Al Shawi, Maryam</au><au>Verana, Gabrielle</au><au>Puri, Ashana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dermaplaning for Transdermal Drug Permeation Enhancement: A Qualitative and Quantitative Assessment</atitle><jtitle>AAPS PharmSciTech</jtitle><stitle>AAPS PharmSciTech</stitle><addtitle>AAPS PharmSciTech</addtitle><date>2023-02-01</date><risdate>2023</risdate><volume>24</volume><issue>2</issue><spage>54</spage><epage>54</epage><pages>54-54</pages><artnum>54</artnum><issn>1530-9932</issn><eissn>1530-9932</eissn><abstract>In this study, we sought to investigate the effect of dermaplaning, a popular cosmeceutical skin rejuvenation technique on the permeation of drugs. Baclofen and diclofenac were used as hydrophilic and hydrophobic model drugs, respectively. A specific area of skin was treated with 4 strokes of a dermaplane device. Interindividual variability was assessed by having multiple users operate the device for the study. Dermaplaned skin was histologically evaluated and characterized for resistance drop and the depletion of the stratum corneum (SC). The effect of dermaplaning on drug permeation was investigated via
in vitro
permeation studies. Histology studies depicted the removal of SC and some parts of viable epidermis by dermaplaning. A significant drop in electrical resistance post skin dermaplaning was observed for all treatment groups, signifying the depletion of barrier properties of SC (
p
< 0.05). Consequently, significant drug flux and permeation were observed over 24 h for the model drugs across dermaplaned skin. However, varied absorption profile was observed
in vitro
for both drugs across dermaplaned skin. Dermaplaning displayed a better suitability for significantly enhancing the permeation of the hydrophilic drug, baclofen. Evidence of variation in results post dermaplaning was observed amidst multiple users as well (
p
< 0.05).
Graphical Abstract</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>36725790</pmid><doi>10.1208/s12249-023-02505-y</doi><tpages>1</tpages></addata></record> |
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| subjects | Administration, Cutaneous Baclofen - analysis Baclofen - metabolism Baclofen - pharmacology Biochemistry Biomedical and Life Sciences Biomedicine Biotechnology Epidermis - metabolism Pharmacology/Toxicology Pharmacy Research Article Skin - metabolism Skin Absorption |
| title | Dermaplaning for Transdermal Drug Permeation Enhancement: A Qualitative and Quantitative Assessment |
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