Genipin Attenuates Sepsis-Induced Splenocyte Apoptosis via the Inhibition of Endoplasmic Reticulum Stress

Endoplasmic reticulum (ER) dysfunction is characterized by ER stress, which can be triggered by sepsis. Recent studies have reported that lessening ER stress is a promising therapeutic approach to improving the outcome of sepsis. Genipin is derived from gardenia fruit, which is a traditional Chinese...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2023/02/01, Vol.46(2), pp.187-193
Hauptverfasser:	Luo, Ning, Chen, Gui-bing, Zhang, Teng, Zhao, Jie, Fu, Jing-nan, Lu, Ning, Ma, Tao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Caspase-3 CCAAT/enhancer-binding protein Endoplasmic reticulum Endoplasmic Reticulum Chaperone BiP Endoplasmic Reticulum Stress Genipin Herbal medicine Inflammation Initiation factor eIF-2α Interleukin 6 Kinases Medicinal plants Mice Protein kinase R Proteins Sepsis Sepsis - complications Sepsis - drug therapy Spleen - metabolism Survival Transcription Factor CHOP - metabolism
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