The cysteine S–H stretching mode reports on long‐range conformational changes in pyruvate oxidase from E. coli

The pyruvate oxidases from Escherichia coli (EcPOX) and Lactobacillus plantarum (LpPOX) are both thiamin‐dependent flavoenzymes. Their sequence and structure are closely related, and they catalyse similar reactions—but they differ in their activity pattern: LpPOX is always highly active, EcPOX only...

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Veröffentlicht in:	The FEBS journal 2023-06, Vol.290 (12), p.3258-3269
Hauptverfasser:	Deniz, Erhan, Oberle, Michael, Ulrich, Kristina, Mäntele, Werner, Wille, Georg
Format:	Artikel
Sprache:	eng
Schlagworte:	Activity patterns allostery Cysteine - metabolism cysteines E coli Escherichia coli - metabolism Flavin Flavins - metabolism flavoproteins infrared difference spectroscopy Infrared radiation Lipids Oxidation-Reduction Peptides Proteins Proteolysis Pyruvate oxidase Pyruvate Oxidase - chemistry Pyruvate Oxidase - genetics Pyruvate Oxidase - metabolism Pyruvic acid redox
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