A phase 1 trial of NY‐ESO‐1‐specific TCR‐engineered T‐cell therapy combined with a lymph node‐targeting nanoparticulate peptide vaccine for the treatment of advanced soft tissue sarcoma

The efficacy of immune checkpoint inhibitors is limited in refractory solid tumors. T‐cell receptor gene‐modified T (TCR‐T)‐cell therapy has attracted attention as a new immunotherapy for refractory cold tumors. We first investigated the preclinical efficacy and mode of action of TCR‐T cells combine...

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Veröffentlicht in:	International journal of cancer 2023-06, Vol.152 (12), p.2554-2566
Hauptverfasser:	Ishihara, Mikiya, Nishida, Yoshihiro, Kitano, Shigehisa, Kawai, Akira, Muraoka, Daisuke, Momose, Fumiyasu, Harada, Naozumi, Miyahara, Yoshihiro, Seo, Naohiro, Hattori, Hiroyoshi, Takada, Kohichi, Emori, Makoto, Kakunaga, Shigeki, Endo, Makoto, Matsumoto, Yoshihiro, Sasada, Tetsuro, Sato, Eiichi, Yamada, Tomomi, Matsumine, Akihiko, Nagata, Yasuhiro, Watanabe, Takashi, Kageyama, Shinichi, Shiku, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	adoptive cell therapy Animals Antigens, Neoplasm Cancer Cell therapy Cell- and Tissue-Based Therapy Combined vaccines CXCR3 protein Cytokines Epitopes Esophageal cancer Esophageal Neoplasms Esophageal Squamous Cell Carcinoma Immune checkpoint inhibitors Immunotherapy Lymph nodes Lymphatic system Lymphocytes Lymphocytes T Medical research Mice Nanogels Nanoparticles nanoparticulate vaccine NY‐ESO‐1 Peptides Pullulan Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - metabolism Sarcoma Sarcoma, Synovial - therapy Soft Tissue Neoplasms Soft tissue sarcoma Solid tumors Squamous cell carcinoma Synovial sarcoma T cell receptors TCR‐T‐cell Tumors Vaccines
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