THE VALUE OF SERUM SEROMUCOID IN THE DIFFERENTIAL DIAGNOSIS OF BACTERIAL PNEUMONIA AND TUBERCULOSIS IN HIV-POSITIVE PATIENTS
The aim: To optimize the differential diagnosis of bacterial pneumonia and tuberculosis in HIV-positive patients based on the value of serum seromucoid. Materials and methods: The study included 77 HIV-positive patients with lung pathology. The 1st group consisted of 44 HIV-infected patients with BP...
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| Veröffentlicht in: | Wiadomości lekarskie (1960) 2022, Vol.75 (12), p.3036-3040 |
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| container_title | Wiadomości lekarskie (1960) |
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| creator | Tsyko, Olena V Kozko, Volodymyr M Yurko, Kateryna V Solomennyk, Ganna O Mohylenets, Olena I Merkulova, Nina F |
| description | The aim: To optimize the differential diagnosis of bacterial pneumonia and tuberculosis in HIV-positive patients based on the value of serum seromucoid.
Materials and methods: The study included 77 HIV-positive patients with lung pathology. The 1st group consisted of 44 HIV-infected patients with BP; the 2nd group - of 33 patients with HIV/TB co-infection. Level of SSM, CD4+ T-lymphocytes, HIV-1 RNA viral load was determined. Сlinical, laboratory, microscopic, radiological, microbiological, and statistical methods were used in the research.
Results: In patients with HIV/TB co-infection CD4+ T-lymphocyte level was lower, and viral load was higher than in HIV-infected patients with BP. The level of SSM was statistically significantly elevated in patients of both groups compared with the control (p |
| doi_str_mv | 10.36740/WLek202212124 |
| format | Article |
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Materials and methods: The study included 77 HIV-positive patients with lung pathology. The 1st group consisted of 44 HIV-infected patients with BP; the 2nd group - of 33 patients with HIV/TB co-infection. Level of SSM, CD4+ T-lymphocytes, HIV-1 RNA viral load was determined. Сlinical, laboratory, microscopic, radiological, microbiological, and statistical methods were used in the research.
Results: In patients with HIV/TB co-infection CD4+ T-lymphocyte level was lower, and viral load was higher than in HIV-infected patients with BP. The level of SSM was statistically significantly elevated in patients of both groups compared with the control (p<0,001), but in patients with HIV/TB co-infection the values were statistically significantly higher (p<0,001). In patients with BP, the content of SSM≤15,95 TU occurred statistically significantly more often than in patients with TB (χ2= 65,5; p <0,001). No statistically significant relationship between SSM content and CD4+ T-lymphocyte levels was found.
Conclusions: The content of SSM in patients with HIV/TB co-infection is statistically significantly higher than in the group of HIV-infected patients with BP. Determination of SSM level can be used as a rapid method of differential diagnosis of BP and TB in HIV-positive patients that will allow to optimize the diagnostic algorithm at the early stage of hospitalization and to receive the necessary timely treatment for HIV-infected patients.</description><identifier>ISSN: 0043-5147</identifier><identifier>DOI: 10.36740/WLek202212124</identifier><identifier>PMID: 36723323</identifier><language>eng</language><publisher>Poland</publisher><subject>Coinfection ; Diagnosis, Differential ; HIV Infections - complications ; HIV Infections - diagnosis ; Humans ; Orosomucoid ; Pneumonia, Bacterial - diagnosis ; Tuberculosis</subject><ispartof>Wiadomości lekarskie (1960), 2022, Vol.75 (12), p.3036-3040</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c165t-4238b132b4a7e9edf703789b5ec9690d5732877b8e7a8772993d133edf368a223</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36723323$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tsyko, Olena V</creatorcontrib><creatorcontrib>Kozko, Volodymyr M</creatorcontrib><creatorcontrib>Yurko, Kateryna V</creatorcontrib><creatorcontrib>Solomennyk, Ganna O</creatorcontrib><creatorcontrib>Mohylenets, Olena I</creatorcontrib><creatorcontrib>Merkulova, Nina F</creatorcontrib><title>THE VALUE OF SERUM SEROMUCOID IN THE DIFFERENTIAL DIAGNOSIS OF BACTERIAL PNEUMONIA AND TUBERCULOSIS IN HIV-POSITIVE PATIENTS</title><title>Wiadomości lekarskie (1960)</title><addtitle>Wiad Lek</addtitle><description>The aim: To optimize the differential diagnosis of bacterial pneumonia and tuberculosis in HIV-positive patients based on the value of serum seromucoid.
Materials and methods: The study included 77 HIV-positive patients with lung pathology. The 1st group consisted of 44 HIV-infected patients with BP; the 2nd group - of 33 patients with HIV/TB co-infection. Level of SSM, CD4+ T-lymphocytes, HIV-1 RNA viral load was determined. Сlinical, laboratory, microscopic, radiological, microbiological, and statistical methods were used in the research.
Results: In patients with HIV/TB co-infection CD4+ T-lymphocyte level was lower, and viral load was higher than in HIV-infected patients with BP. The level of SSM was statistically significantly elevated in patients of both groups compared with the control (p<0,001), but in patients with HIV/TB co-infection the values were statistically significantly higher (p<0,001). In patients with BP, the content of SSM≤15,95 TU occurred statistically significantly more often than in patients with TB (χ2= 65,5; p <0,001). No statistically significant relationship between SSM content and CD4+ T-lymphocyte levels was found.
Conclusions: The content of SSM in patients with HIV/TB co-infection is statistically significantly higher than in the group of HIV-infected patients with BP. Determination of SSM level can be used as a rapid method of differential diagnosis of BP and TB in HIV-positive patients that will allow to optimize the diagnostic algorithm at the early stage of hospitalization and to receive the necessary timely treatment for HIV-infected patients.</description><subject>Coinfection</subject><subject>Diagnosis, Differential</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - diagnosis</subject><subject>Humans</subject><subject>Orosomucoid</subject><subject>Pneumonia, Bacterial - diagnosis</subject><subject>Tuberculosis</subject><issn>0043-5147</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkMtPwkAQxvegEaJcPZo9einuo91tj6VsYZPSkj7w2PSxJCgIduFg4h_vFtDEmWQmM_l93-ED4BGjMWXcRi-vkXoniBBs2r4BQ4RsajnY5gMw0voNmWIORsy7AwOjIJQSOgTf-VzAlR8VAiYhzERaLPqZLIogkVMoY9gDUxmGIhVxLv3IHP4sTjKZ9YqJH-Qi7d_LWBSLJJY-9OMpzIuJSIMiOnPGZS5X1tIcuVwJuPRzacyyB3C7rrZaja77HhShyIO5FSUzGfiR1WDmHC2bULfGlNR2xZWn2jVHlLte7ajGYx5qHU6Jy3ntKl6ZTTyPtphSA1LmVoTQe_B88T10-8-T0sdyt9GN2m6rD7U_6ZJwjhl1GerR8QVtur3WnVqXh26zq7qvEqPyHHT5L2gjeLp6n-qdav_w34jpD2AKbyc</recordid><startdate>2022</startdate><enddate>2022</enddate><creator>Tsyko, Olena V</creator><creator>Kozko, Volodymyr M</creator><creator>Yurko, Kateryna V</creator><creator>Solomennyk, Ganna O</creator><creator>Mohylenets, Olena I</creator><creator>Merkulova, Nina F</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2022</creationdate><title>THE VALUE OF SERUM SEROMUCOID IN THE DIFFERENTIAL DIAGNOSIS OF BACTERIAL PNEUMONIA AND TUBERCULOSIS IN HIV-POSITIVE PATIENTS</title><author>Tsyko, Olena V ; Kozko, Volodymyr M ; Yurko, Kateryna V ; Solomennyk, Ganna O ; Mohylenets, Olena I ; Merkulova, Nina F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c165t-4238b132b4a7e9edf703789b5ec9690d5732877b8e7a8772993d133edf368a223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Coinfection</topic><topic>Diagnosis, Differential</topic><topic>HIV Infections - complications</topic><topic>HIV Infections - diagnosis</topic><topic>Humans</topic><topic>Orosomucoid</topic><topic>Pneumonia, Bacterial - diagnosis</topic><topic>Tuberculosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tsyko, Olena V</creatorcontrib><creatorcontrib>Kozko, Volodymyr M</creatorcontrib><creatorcontrib>Yurko, Kateryna V</creatorcontrib><creatorcontrib>Solomennyk, Ganna O</creatorcontrib><creatorcontrib>Mohylenets, Olena I</creatorcontrib><creatorcontrib>Merkulova, Nina F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Wiadomości lekarskie (1960)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tsyko, Olena V</au><au>Kozko, Volodymyr M</au><au>Yurko, Kateryna V</au><au>Solomennyk, Ganna O</au><au>Mohylenets, Olena I</au><au>Merkulova, Nina F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>THE VALUE OF SERUM SEROMUCOID IN THE DIFFERENTIAL DIAGNOSIS OF BACTERIAL PNEUMONIA AND TUBERCULOSIS IN HIV-POSITIVE PATIENTS</atitle><jtitle>Wiadomości lekarskie (1960)</jtitle><addtitle>Wiad Lek</addtitle><date>2022</date><risdate>2022</risdate><volume>75</volume><issue>12</issue><spage>3036</spage><epage>3040</epage><pages>3036-3040</pages><issn>0043-5147</issn><abstract>The aim: To optimize the differential diagnosis of bacterial pneumonia and tuberculosis in HIV-positive patients based on the value of serum seromucoid.
Materials and methods: The study included 77 HIV-positive patients with lung pathology. The 1st group consisted of 44 HIV-infected patients with BP; the 2nd group - of 33 patients with HIV/TB co-infection. Level of SSM, CD4+ T-lymphocytes, HIV-1 RNA viral load was determined. Сlinical, laboratory, microscopic, radiological, microbiological, and statistical methods were used in the research.
Results: In patients with HIV/TB co-infection CD4+ T-lymphocyte level was lower, and viral load was higher than in HIV-infected patients with BP. The level of SSM was statistically significantly elevated in patients of both groups compared with the control (p<0,001), but in patients with HIV/TB co-infection the values were statistically significantly higher (p<0,001). In patients with BP, the content of SSM≤15,95 TU occurred statistically significantly more often than in patients with TB (χ2= 65,5; p <0,001). No statistically significant relationship between SSM content and CD4+ T-lymphocyte levels was found.
Conclusions: The content of SSM in patients with HIV/TB co-infection is statistically significantly higher than in the group of HIV-infected patients with BP. Determination of SSM level can be used as a rapid method of differential diagnosis of BP and TB in HIV-positive patients that will allow to optimize the diagnostic algorithm at the early stage of hospitalization and to receive the necessary timely treatment for HIV-infected patients.</abstract><cop>Poland</cop><pmid>36723323</pmid><doi>10.36740/WLek202212124</doi><tpages>5</tpages></addata></record> |
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| subjects | Coinfection Diagnosis, Differential HIV Infections - complications HIV Infections - diagnosis Humans Orosomucoid Pneumonia, Bacterial - diagnosis Tuberculosis |
| title | THE VALUE OF SERUM SEROMUCOID IN THE DIFFERENTIAL DIAGNOSIS OF BACTERIAL PNEUMONIA AND TUBERCULOSIS IN HIV-POSITIVE PATIENTS |
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