Generation and reaction of alanyl radicals in open flasks

The generation and Giese-type reaction of alanyl radicals under metal-free reaction conditions is described. The procedure is operationally simple, occurring at ambient temperature in an open reaction vessel, and requiring short reaction times (≤5 min). The reaction occurs without epimerization and...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2023-02, Vol.59 (15), p.294-297
Hauptverfasser:	Tatunashvili, Elene, Maloney, Callan J, Chan, Bun, McErlean, Christopher S. P
Format:	Artikel
Sprache:	eng
Schlagworte:	Ambient temperature Amino acids Electromagnetic absorption Flasks Fluorescence Peptides
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creator	Tatunashvili, Elene Maloney, Callan J Chan, Bun McErlean, Christopher S. P
description	The generation and Giese-type reaction of alanyl radicals under metal-free reaction conditions is described. The procedure is operationally simple, occurring at ambient temperature in an open reaction vessel, and requiring short reaction times (≤5 min). The reaction occurs without epimerization and provides ready access to non-proteinogenic amino acids and peptides. Importantly, the process is tolerant of light absorbing groups including commonly used fluorescent tags. The generation and Giese-type reaction of alanyl radicals under metal-free reaction conditions is described.
doi_str_mv	10.1039/d2cc06211a
format	Article
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source	Royal Society Of Chemistry Journals; Alma/SFX Local Collection
subjects	Ambient temperature Amino acids Electromagnetic absorption Flasks Fluorescence Peptides
title	Generation and reaction of alanyl radicals in open flasks
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