Aucubin protects mouse cochlear hair cells from cisplatin-induced ototoxicity via activation of the PI3K/AKT/STAT3 pathway

[Display omitted] Cisplatin is commonly used to treat cancers and is associated with a significant risk of irreversible sensorineural hearing loss. However, no effective preventive strategies are available for cisplatin-induced HL. Therefore, significant efforts have been made to discover new drugs...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemical pharmacology 2023-03, Vol.209, p.115440-115440, Article 115440
Hauptverfasser:	Jiang, Yumeng, Li, Zhuangzhuang, Ma, Qiang, Dong, Wenqi, Yao, Qingxiu, Yu, Dongzhen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Apoptosis Aucubin Cisplatin Cisplatin - pharmacology Cochlea - metabolism Hair Cells, Auditory Hearing Loss - chemically induced Hearing Loss - drug therapy Hearing Loss - prevention & control Hearing Loss, Sensorineural - drug therapy Hearing Loss, Sensorineural - metabolism Mice Ototoxicity Ototoxicity - metabolism p-STAT3 Phosphatidylinositol 3-Kinases - metabolism PI3K/AKT Proto-Oncogene Proteins c-akt - metabolism Reactive Oxygen Species - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!