Emotion recognition and baseline cortisol levels relationship in early Alzheimer disease
Emotion recognition is often impaired in early Alzheimer’s disease (AD) and can be evaluated using the Reading the Mind in the Eyes Test (RMET). Similarly, cortisol levels can affect cognition and could be considered a biomarker of AD. The aim of this study was to analyse the relationship between th...
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| Veröffentlicht in: | Biological psychology 2023-02, Vol.177, p.108511-108511, Article 108511 |
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| container_title | Biological psychology |
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| creator | Ferrer-Cairols, I. Ferré-González, L. García-Lluch, G. Peña-Bautista, C. Álvarez-Sánchez, L. Baquero, M. Cháfer-Pericás, C. |
| description | Emotion recognition is often impaired in early Alzheimer’s disease (AD) and can be evaluated using the Reading the Mind in the Eyes Test (RMET). Similarly, cortisol levels can affect cognition and could be considered a biomarker of AD.
The aim of this study was to analyse the relationship between the emotion recognition task and cortisol levels in participants with early Alzheimer Disease (AD).
Complex emotion recognition was assessed with RMET, and plasma cortisol levels were determined by mass spectrometry in participants classified into mild cognitive impairment (MCI) due to AD (n = 25), mild dementia (MD) due to AD (n = 20), MCI non-AD (n = 34), MD non-AD (n = 13) and healthy controls (HC) (n = 16) groups.
Significantly lower positive emotion recognition was found in the MCI non-AD group (p = 0.02) and lower emotion recognition in MD (AD and non-AD) groups (p |
| doi_str_mv | 10.1016/j.biopsycho.2023.108511 |
| format | Article |
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The aim of this study was to analyse the relationship between the emotion recognition task and cortisol levels in participants with early Alzheimer Disease (AD).
Complex emotion recognition was assessed with RMET, and plasma cortisol levels were determined by mass spectrometry in participants classified into mild cognitive impairment (MCI) due to AD (n = 25), mild dementia (MD) due to AD (n = 20), MCI non-AD (n = 34), MD non-AD (n = 13) and healthy controls (HC) (n = 16) groups.
Significantly lower positive emotion recognition was found in the MCI non-AD group (p = 0.02) and lower emotion recognition in MD (AD and non-AD) groups (p < 0.01) compared to the healthy group. In addition, significant differences were observed between cortisol and all RMET scores among the MCI and MD groups (p < 0.01). A significant correlation was also obtained between total and neutral RMET scores and cortisol levels in MD groups (p = 0.01).
These outcomes suggest that detection of positive emotion dysfunction could help to identify MCI non-AD patients. Furthermore, general impaired emotion recognition and high cortisol levels may be associated with cognitive impairment at mild dementia level.
•-Significant lower positive emotion recognition in MCI non-AD versus HC.•-Significant lower emotion recognition in the MD groups versus HC.•-Significant differences in cortisol and RMET scores between the MCI and MD groups.•-Association between RMET total and neutral scores and higher levels of cortisol in MD groups.</description><identifier>ISSN: 0301-0511</identifier><identifier>EISSN: 1873-6246</identifier><identifier>DOI: 10.1016/j.biopsycho.2023.108511</identifier><identifier>PMID: 36716987</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Alzheimer disease ; Alzheimer Disease - diagnosis ; Alzheimer Disease - psychology ; Cognitive Dysfunction ; Cortisol ; Dementia ; Emotion recognition ; Emotions ; Humans ; Hydrocortisone ; RMET</subject><ispartof>Biological psychology, 2023-02, Vol.177, p.108511-108511, Article 108511</ispartof><rights>2023 Elsevier B.V.</rights><rights>Copyright © 2023 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-f00df76d678863e11e947d232eac718d21b4b1b3e482351e4833d5695d70b89e3</citedby><cites>FETCH-LOGICAL-c371t-f00df76d678863e11e947d232eac718d21b4b1b3e482351e4833d5695d70b89e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.biopsycho.2023.108511$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36716987$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ferrer-Cairols, I.</creatorcontrib><creatorcontrib>Ferré-González, L.</creatorcontrib><creatorcontrib>García-Lluch, G.</creatorcontrib><creatorcontrib>Peña-Bautista, C.</creatorcontrib><creatorcontrib>Álvarez-Sánchez, L.</creatorcontrib><creatorcontrib>Baquero, M.</creatorcontrib><creatorcontrib>Cháfer-Pericás, C.</creatorcontrib><title>Emotion recognition and baseline cortisol levels relationship in early Alzheimer disease</title><title>Biological psychology</title><addtitle>Biol Psychol</addtitle><description>Emotion recognition is often impaired in early Alzheimer’s disease (AD) and can be evaluated using the Reading the Mind in the Eyes Test (RMET). Similarly, cortisol levels can affect cognition and could be considered a biomarker of AD.
The aim of this study was to analyse the relationship between the emotion recognition task and cortisol levels in participants with early Alzheimer Disease (AD).
Complex emotion recognition was assessed with RMET, and plasma cortisol levels were determined by mass spectrometry in participants classified into mild cognitive impairment (MCI) due to AD (n = 25), mild dementia (MD) due to AD (n = 20), MCI non-AD (n = 34), MD non-AD (n = 13) and healthy controls (HC) (n = 16) groups.
Significantly lower positive emotion recognition was found in the MCI non-AD group (p = 0.02) and lower emotion recognition in MD (AD and non-AD) groups (p < 0.01) compared to the healthy group. In addition, significant differences were observed between cortisol and all RMET scores among the MCI and MD groups (p < 0.01). A significant correlation was also obtained between total and neutral RMET scores and cortisol levels in MD groups (p = 0.01).
These outcomes suggest that detection of positive emotion dysfunction could help to identify MCI non-AD patients. Furthermore, general impaired emotion recognition and high cortisol levels may be associated with cognitive impairment at mild dementia level.
•-Significant lower positive emotion recognition in MCI non-AD versus HC.•-Significant lower emotion recognition in the MD groups versus HC.•-Significant differences in cortisol and RMET scores between the MCI and MD groups.•-Association between RMET total and neutral scores and higher levels of cortisol in MD groups.</description><subject>Alzheimer disease</subject><subject>Alzheimer Disease - diagnosis</subject><subject>Alzheimer Disease - psychology</subject><subject>Cognitive Dysfunction</subject><subject>Cortisol</subject><subject>Dementia</subject><subject>Emotion recognition</subject><subject>Emotions</subject><subject>Humans</subject><subject>Hydrocortisone</subject><subject>RMET</subject><issn>0301-0511</issn><issn>1873-6246</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOwzAQRS0EoqXwC5AlmxRPnNjpsqrKQ6rEBiR2VmJPqSsnLnZaqXw9Lindspqr0bkz0iHkDugYKPCH9bg2bhP2auXGGc1Y3JYFwBkZQilYyrOcn5MhZRRSGvcDchXCmtKYi-KSDBgXwCelGJKPeeM649rEo3KfrfnNVauTugpoTYuJcr4zwdnE4g5tiKCtDlRYmU1i2gQrb_fJ1H6v0DToE20Cxu41uVhWNuDNcY7I--P8bfacLl6fXmbTRaqYgC5dUqqXgmsuypIzBMBJLnTGMqyUgFJnUOc11AzzMmMFxMGYLvik0ILW5QTZiNz3dzfefW0xdLIxQaG1VYtuG2QmBDCWc0EjKnpUeReCx6XceNNUfi-ByoNWuZYnrfKgVfZaY_P2-GRbN6hPvT-PEZj2QDSEO4NeBmWwVahNFNtJ7cy_T34Af-6N7w</recordid><startdate>202302</startdate><enddate>202302</enddate><creator>Ferrer-Cairols, I.</creator><creator>Ferré-González, L.</creator><creator>García-Lluch, G.</creator><creator>Peña-Bautista, C.</creator><creator>Álvarez-Sánchez, L.</creator><creator>Baquero, M.</creator><creator>Cháfer-Pericás, C.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202302</creationdate><title>Emotion recognition and baseline cortisol levels relationship in early Alzheimer disease</title><author>Ferrer-Cairols, I. ; Ferré-González, L. ; García-Lluch, G. ; Peña-Bautista, C. ; Álvarez-Sánchez, L. ; Baquero, M. ; Cháfer-Pericás, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-f00df76d678863e11e947d232eac718d21b4b1b3e482351e4833d5695d70b89e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Alzheimer disease</topic><topic>Alzheimer Disease - diagnosis</topic><topic>Alzheimer Disease - psychology</topic><topic>Cognitive Dysfunction</topic><topic>Cortisol</topic><topic>Dementia</topic><topic>Emotion recognition</topic><topic>Emotions</topic><topic>Humans</topic><topic>Hydrocortisone</topic><topic>RMET</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ferrer-Cairols, I.</creatorcontrib><creatorcontrib>Ferré-González, L.</creatorcontrib><creatorcontrib>García-Lluch, G.</creatorcontrib><creatorcontrib>Peña-Bautista, C.</creatorcontrib><creatorcontrib>Álvarez-Sánchez, L.</creatorcontrib><creatorcontrib>Baquero, M.</creatorcontrib><creatorcontrib>Cháfer-Pericás, C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biological psychology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ferrer-Cairols, I.</au><au>Ferré-González, L.</au><au>García-Lluch, G.</au><au>Peña-Bautista, C.</au><au>Álvarez-Sánchez, L.</au><au>Baquero, M.</au><au>Cháfer-Pericás, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Emotion recognition and baseline cortisol levels relationship in early Alzheimer disease</atitle><jtitle>Biological psychology</jtitle><addtitle>Biol Psychol</addtitle><date>2023-02</date><risdate>2023</risdate><volume>177</volume><spage>108511</spage><epage>108511</epage><pages>108511-108511</pages><artnum>108511</artnum><issn>0301-0511</issn><eissn>1873-6246</eissn><abstract>Emotion recognition is often impaired in early Alzheimer’s disease (AD) and can be evaluated using the Reading the Mind in the Eyes Test (RMET). Similarly, cortisol levels can affect cognition and could be considered a biomarker of AD.
The aim of this study was to analyse the relationship between the emotion recognition task and cortisol levels in participants with early Alzheimer Disease (AD).
Complex emotion recognition was assessed with RMET, and plasma cortisol levels were determined by mass spectrometry in participants classified into mild cognitive impairment (MCI) due to AD (n = 25), mild dementia (MD) due to AD (n = 20), MCI non-AD (n = 34), MD non-AD (n = 13) and healthy controls (HC) (n = 16) groups.
Significantly lower positive emotion recognition was found in the MCI non-AD group (p = 0.02) and lower emotion recognition in MD (AD and non-AD) groups (p < 0.01) compared to the healthy group. In addition, significant differences were observed between cortisol and all RMET scores among the MCI and MD groups (p < 0.01). A significant correlation was also obtained between total and neutral RMET scores and cortisol levels in MD groups (p = 0.01).
These outcomes suggest that detection of positive emotion dysfunction could help to identify MCI non-AD patients. Furthermore, general impaired emotion recognition and high cortisol levels may be associated with cognitive impairment at mild dementia level.
•-Significant lower positive emotion recognition in MCI non-AD versus HC.•-Significant lower emotion recognition in the MD groups versus HC.•-Significant differences in cortisol and RMET scores between the MCI and MD groups.•-Association between RMET total and neutral scores and higher levels of cortisol in MD groups.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>36716987</pmid><doi>10.1016/j.biopsycho.2023.108511</doi><tpages>1</tpages></addata></record> |
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| subjects | Alzheimer disease Alzheimer Disease - diagnosis Alzheimer Disease - psychology Cognitive Dysfunction Cortisol Dementia Emotion recognition Emotions Humans Hydrocortisone RMET |
| title | Emotion recognition and baseline cortisol levels relationship in early Alzheimer disease |
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