Discovery of novel 2-hydroxyl-4-benzyloxybenzyl aniline derivatives as potential multifunctional agents for the treatment of Parkinson's disease

To discover novel multifunctional agents for the treatment of Parkinson's disease, a series of 2-hydroxyl-4-benzyloxybenzyl aniline derivatives was designed, synthesized and evaluated. The biological screening indicated that representative compound 6h possessed excellent MAO-B inhibition (IC50 ...

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Veröffentlicht in:	European journal of medicinal chemistry 2023-03, Vol.249, p.115142-115142, Article 115142
Hauptverfasser:	Cao, Zhongcheng, Fu, Xianwu, Wang, Xingyue, Zhang, Tianlong, Zhong, Lei, Xia, Qian, Zhu, Jiang
Format:	Artikel
Sprache:	eng
Schlagworte:	2-hydroxyl-4-benzyloxybenzyl aniline derivatives Animals Anti-neuroinflammatory agents Antioxidants Antioxidants - pharmacology Chelating Agents - pharmacology Hydroxyl Radical MAO-B inhibitors Mice Monoamine Oxidase - metabolism Monoamine Oxidase Inhibitors - pharmacology Monoamine Oxidase Inhibitors - therapeutic use Multifunctional anti-PD agents Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Parkinson Disease - drug therapy Parkinson's disease
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