Neonatal Fc receptor inhibition enables adeno-associated virus gene therapy despite pre-existing humoral immunity

Advances in adeno-associated virus-based gene therapy are transforming our ability to treat rare genetic disorders and address other unmet medical needs. However, the natural prevalence of anti-adeno-associated virus neutralizing antibodies in humans currently limits the population who can benefit f...

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Veröffentlicht in:	Human gene therapy 2023-10, Vol.34 (ja), p.1022-1032
Hauptverfasser:	Horiuchi, Makoto, Hinderer, Christian J., Shankle, Hailey N., Hayashi, Peter M., Chichester, Jessica A., Kissel, Casey, Bell, Peter, Dyer, Cecilia, Wilson, James M.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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