Endothelial hyperactivation of mutant MAP3K3 induces cerebral cavernous malformation enhanced by PIK3CA GOF mutation

Cerebral cavernous malformations (CCMs) refer to a common vascular abnormality that affects up to 0.5% of the population. A somatic gain-of-function mutation in MAP3K3 (p.I441M) was recently reported in sporadic CCMs, frequently accompanied by somatic activating PIK3CA mutations in diseased endothel...

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Veröffentlicht in:	Angiogenesis (London) 2023-05, Vol.26 (2), p.295-312
Hauptverfasser:	Huo, Ran, Yang, Yingxi, Sun, Yingfan, Zhou, Qiuxia, Zhao, Shaozhi, Mo, Zongchao, Xu, Hongyuan, Wang, Jie, Weng, Jiancong, Jiao, Yuming, Zhang, Junze, He, Qiheng, Wang, Shuo, Zhao, Jizong, Wang, Jiguang, Cao, Yong
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Animals Apoptosis Biomedical and Life Sciences Biomedicine Brain Cancer Research Cardiology CCM2 protein Cell Biology Cell proliferation Class I Phosphatidylinositol 3-Kinases - genetics Class I Phosphatidylinositol 3-Kinases - metabolism Endothelial cells Endothelial Cells - metabolism Endothelium Endothelium - metabolism Gene sequencing Hemangioma, Cavernous, Central Nervous System - genetics Hemangioma, Cavernous, Central Nervous System - pathology Lesions MAP Kinase Kinase Kinase 3 - genetics MAP Kinase Kinase Kinase 3 - metabolism Mice Molecular modelling Mutation Mutation - genetics Oncology Ophthalmology Original Paper Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism Polymerase chain reaction Proto-Oncogene Proteins - genetics Signaling Spinal cord
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