Alterations of ATG4A and LC3B in neurons derived from Alzheimer's disease patients

We investigated the alterations in autophagy‐related molecules in neurons differentiated from induced pluripotent stem cells obtained from patients with Alzheimer's disease (AD). Consistent with our previous microarray data, ATG4A protein was upregulated in the neurons derived from a familial A...

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Veröffentlicht in:	Genes to cells : devoted to molecular & cellular mechanisms 2023-04, Vol.28 (4), p.319-325
Hauptverfasser:	Shirotani, Keiro, Watanabe, Kaori, Hatta, Daisuke, Kutoku, Yumiko, Ohsawa, Yutaka, Sunada, Yoshihide, Kondo, Takayuki, Inoue, Haruhisa, Iwata, Nobuhisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - genetics Alzheimer Disease - pathology Alzheimer's disease Amyloid beta-Peptides - genetics Amyloid beta-Peptides - metabolism amyloid β ATG4A Autophagy Autophagy-Related Proteins - genetics Autophagy-Related Proteins - metabolism Cell differentiation Cysteine Endopeptidases - genetics Cysteine Endopeptidases - metabolism Humans Induced Pluripotent Stem Cells - metabolism Intracellular iPSC LC3B Mutation Neurodegenerative diseases Neurons Neurons - metabolism Pluripotency Protein arrays β-Amyloid
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