Cancer-associated fibroblasts in papillary thyroid carcinoma
Papillary thyroid carcinoma (PTC) has a relatively good prognosis, yet there are some invasive PTC cases with worse clinicopathological features and poor outcome. Cancer-associated fibroblasts (CAFs) play an important role in cancer invasion and metastasis. This study aimed to investigate the expres...
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| Veröffentlicht in: | Clinical and experimental medicine 2023-10, Vol.23 (6), p.2209-2220 |
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| creator | Zhu, Li Zhang, Xuemei Zhang, Shuhan Zhang, Qicheng Cao, Limin Zhang, Yujie Wang, Dan Liang, Xiaohui Wu, Weiming Wu, Shuanghu Jiang, Ruoyu Liu, Yue Zhao, Xue Zhou, Guiming Xu, Ke Meng, Zhaowei |
| description | Papillary thyroid carcinoma (PTC) has a relatively good prognosis, yet there are some invasive PTC cases with worse clinicopathological features and poor outcome. Cancer-associated fibroblasts (CAFs) play an important role in cancer invasion and metastasis. This study aimed to investigate the expression of marker proteins of CAFs in PTC and their correlations with clinicopathological features through immunohistochemistry. The medical records of 125 PTC patients were reviewed in this study, whose specimens were retrieved for immunohistochemistry. Four CAFs marker proteins, FAP fibroblast activated protein (FAP), α-smooth muscle actin (α-SMA), Vimentin and platelet-derived growth factor receptor-α(PDGFR-α), were stained and scored. Then, statistical analyses were performed. The immunoreactivity scores of FAP and α-SMA correlated with tumor size, BRAF mutation, extrathyroidal, invasion, pathological subtype, lymph node metastasis and ATA risk stratification. Moreover, binary logistic regression analysis and receiver operating characteristic curves showed that high FAP and α-SMA immunoreactivity scores were risk factors for extrathyroidal invasion, BRAF mutation, multi-focality and lymph node metastasis (especially N1b) with good sensitivity and accuracy in prediction. A better performance was found in FAP than α-SMA. Strong expressions of CAFs were risk factors for worse thyroid cancer clinicopathological features. FAP was the better CAFs marker for PTC. |
| doi_str_mv | 10.1007/s10238-023-00998-2 |
| format | Article |
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Cancer-associated fibroblasts (CAFs) play an important role in cancer invasion and metastasis. This study aimed to investigate the expression of marker proteins of CAFs in PTC and their correlations with clinicopathological features through immunohistochemistry. The medical records of 125 PTC patients were reviewed in this study, whose specimens were retrieved for immunohistochemistry. Four CAFs marker proteins, FAP fibroblast activated protein (FAP), α-smooth muscle actin (α-SMA), Vimentin and platelet-derived growth factor receptor-α(PDGFR-α), were stained and scored. Then, statistical analyses were performed. The immunoreactivity scores of FAP and α-SMA correlated with tumor size, BRAF mutation, extrathyroidal, invasion, pathological subtype, lymph node metastasis and ATA risk stratification. Moreover, binary logistic regression analysis and receiver operating characteristic curves showed that high FAP and α-SMA immunoreactivity scores were risk factors for extrathyroidal invasion, BRAF mutation, multi-focality and lymph node metastasis (especially N1b) with good sensitivity and accuracy in prediction. A better performance was found in FAP than α-SMA. Strong expressions of CAFs were risk factors for worse thyroid cancer clinicopathological features. FAP was the better CAFs marker for PTC.</description><identifier>ISSN: 1591-9528</identifier><identifier>ISSN: 1591-8890</identifier><identifier>EISSN: 1591-9528</identifier><identifier>DOI: 10.1007/s10238-023-00998-2</identifier><identifier>PMID: 36715834</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Actin ; Clinical Practice ; Fibroblasts ; Hematology ; Immunohistochemistry ; Internal Medicine ; Lymph nodes ; Lymphatic system ; Medical records ; Medicine ; Medicine & Public Health ; Metastases ; Metastasis ; Mutation ; Oncology ; Papillary thyroid carcinoma ; Platelet-derived growth factor ; Platelet-derived growth factor receptors ; Risk factors ; Smooth muscle ; Statistical analysis ; Thyroid cancer ; Vimentin</subject><ispartof>Clinical and experimental medicine, 2023-10, Vol.23 (6), p.2209-2220</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Switzerland AG 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-19a292b7a348b646448d0e942a76a0e37dad53d83e447bb18cc151a1bc8d7b623</citedby><cites>FETCH-LOGICAL-c375t-19a292b7a348b646448d0e942a76a0e37dad53d83e447bb18cc151a1bc8d7b623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10238-023-00998-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10238-023-00998-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36715834$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhu, Li</creatorcontrib><creatorcontrib>Zhang, Xuemei</creatorcontrib><creatorcontrib>Zhang, Shuhan</creatorcontrib><creatorcontrib>Zhang, Qicheng</creatorcontrib><creatorcontrib>Cao, Limin</creatorcontrib><creatorcontrib>Zhang, Yujie</creatorcontrib><creatorcontrib>Wang, Dan</creatorcontrib><creatorcontrib>Liang, Xiaohui</creatorcontrib><creatorcontrib>Wu, Weiming</creatorcontrib><creatorcontrib>Wu, Shuanghu</creatorcontrib><creatorcontrib>Jiang, Ruoyu</creatorcontrib><creatorcontrib>Liu, Yue</creatorcontrib><creatorcontrib>Zhao, Xue</creatorcontrib><creatorcontrib>Zhou, Guiming</creatorcontrib><creatorcontrib>Xu, Ke</creatorcontrib><creatorcontrib>Meng, Zhaowei</creatorcontrib><title>Cancer-associated fibroblasts in papillary thyroid carcinoma</title><title>Clinical and experimental medicine</title><addtitle>Clin Exp Med</addtitle><addtitle>Clin Exp Med</addtitle><description>Papillary thyroid carcinoma (PTC) has a relatively good prognosis, yet there are some invasive PTC cases with worse clinicopathological features and poor outcome. Cancer-associated fibroblasts (CAFs) play an important role in cancer invasion and metastasis. This study aimed to investigate the expression of marker proteins of CAFs in PTC and their correlations with clinicopathological features through immunohistochemistry. The medical records of 125 PTC patients were reviewed in this study, whose specimens were retrieved for immunohistochemistry. Four CAFs marker proteins, FAP fibroblast activated protein (FAP), α-smooth muscle actin (α-SMA), Vimentin and platelet-derived growth factor receptor-α(PDGFR-α), were stained and scored. Then, statistical analyses were performed. The immunoreactivity scores of FAP and α-SMA correlated with tumor size, BRAF mutation, extrathyroidal, invasion, pathological subtype, lymph node metastasis and ATA risk stratification. Moreover, binary logistic regression analysis and receiver operating characteristic curves showed that high FAP and α-SMA immunoreactivity scores were risk factors for extrathyroidal invasion, BRAF mutation, multi-focality and lymph node metastasis (especially N1b) with good sensitivity and accuracy in prediction. A better performance was found in FAP than α-SMA. Strong expressions of CAFs were risk factors for worse thyroid cancer clinicopathological features. FAP was the better CAFs marker for PTC.</description><subject>Actin</subject><subject>Clinical Practice</subject><subject>Fibroblasts</subject><subject>Hematology</subject><subject>Immunohistochemistry</subject><subject>Internal Medicine</subject><subject>Lymph nodes</subject><subject>Lymphatic system</subject><subject>Medical records</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Mutation</subject><subject>Oncology</subject><subject>Papillary thyroid carcinoma</subject><subject>Platelet-derived growth factor</subject><subject>Platelet-derived growth factor receptors</subject><subject>Risk factors</subject><subject>Smooth muscle</subject><subject>Statistical analysis</subject><subject>Thyroid cancer</subject><subject>Vimentin</subject><issn>1591-9528</issn><issn>1591-8890</issn><issn>1591-9528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kDlPAzEQhS0EIiHwByjQSjQ0C-Nj116JBkVcUiQaqC1fAUd7BHu3yL_HYcMhCpqZkfzNm-eH0CmGSwzAryIGQkWeSg5QVSIne2iKiwrnVUHE_q95go5iXAHgQlA4RBNa8u3Ipuh6rlrjQq5i7IxXvbPZ0uvQ6VrFPma-zdZq7etahU3Wv21C521mVDC-7Rp1jA6Wqo7uZNdn6OXu9nn-kC-e7h_nN4vcUF70Oa4UqYjmijKhS1YyJiy4ihHFSwWOcqtsQa2gjjGuNRbG4AIrrI2wXJeEztDFqLsO3fvgYi8bH41LrlrXDVESzjFUgEua0PM_6KobQpvcSSI4cMIFQKLISJnQxRjcUq6Db9IfJQa5zVaO2cpU5Ge2cuvibCc96MbZ75WvMBNARyCmp_bVhZ_b_8h-APsPgyE</recordid><startdate>20231001</startdate><enddate>20231001</enddate><creator>Zhu, Li</creator><creator>Zhang, Xuemei</creator><creator>Zhang, Shuhan</creator><creator>Zhang, Qicheng</creator><creator>Cao, Limin</creator><creator>Zhang, Yujie</creator><creator>Wang, Dan</creator><creator>Liang, Xiaohui</creator><creator>Wu, Weiming</creator><creator>Wu, Shuanghu</creator><creator>Jiang, Ruoyu</creator><creator>Liu, Yue</creator><creator>Zhao, Xue</creator><creator>Zhou, Guiming</creator><creator>Xu, Ke</creator><creator>Meng, Zhaowei</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20231001</creationdate><title>Cancer-associated fibroblasts in papillary thyroid carcinoma</title><author>Zhu, Li ; Zhang, Xuemei ; Zhang, Shuhan ; Zhang, Qicheng ; Cao, Limin ; Zhang, Yujie ; Wang, Dan ; Liang, Xiaohui ; Wu, Weiming ; Wu, Shuanghu ; Jiang, Ruoyu ; Liu, Yue ; Zhao, Xue ; Zhou, Guiming ; Xu, Ke ; Meng, Zhaowei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-19a292b7a348b646448d0e942a76a0e37dad53d83e447bb18cc151a1bc8d7b623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Actin</topic><topic>Clinical Practice</topic><topic>Fibroblasts</topic><topic>Hematology</topic><topic>Immunohistochemistry</topic><topic>Internal Medicine</topic><topic>Lymph nodes</topic><topic>Lymphatic system</topic><topic>Medical records</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Mutation</topic><topic>Oncology</topic><topic>Papillary thyroid carcinoma</topic><topic>Platelet-derived growth factor</topic><topic>Platelet-derived growth factor receptors</topic><topic>Risk factors</topic><topic>Smooth muscle</topic><topic>Statistical analysis</topic><topic>Thyroid cancer</topic><topic>Vimentin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhu, Li</creatorcontrib><creatorcontrib>Zhang, Xuemei</creatorcontrib><creatorcontrib>Zhang, Shuhan</creatorcontrib><creatorcontrib>Zhang, Qicheng</creatorcontrib><creatorcontrib>Cao, Limin</creatorcontrib><creatorcontrib>Zhang, Yujie</creatorcontrib><creatorcontrib>Wang, Dan</creatorcontrib><creatorcontrib>Liang, Xiaohui</creatorcontrib><creatorcontrib>Wu, Weiming</creatorcontrib><creatorcontrib>Wu, Shuanghu</creatorcontrib><creatorcontrib>Jiang, Ruoyu</creatorcontrib><creatorcontrib>Liu, Yue</creatorcontrib><creatorcontrib>Zhao, Xue</creatorcontrib><creatorcontrib>Zhou, Guiming</creatorcontrib><creatorcontrib>Xu, Ke</creatorcontrib><creatorcontrib>Meng, Zhaowei</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhu, Li</au><au>Zhang, Xuemei</au><au>Zhang, Shuhan</au><au>Zhang, Qicheng</au><au>Cao, Limin</au><au>Zhang, Yujie</au><au>Wang, Dan</au><au>Liang, Xiaohui</au><au>Wu, Weiming</au><au>Wu, Shuanghu</au><au>Jiang, Ruoyu</au><au>Liu, Yue</au><au>Zhao, Xue</au><au>Zhou, Guiming</au><au>Xu, Ke</au><au>Meng, Zhaowei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cancer-associated fibroblasts in papillary thyroid carcinoma</atitle><jtitle>Clinical and experimental medicine</jtitle><stitle>Clin Exp Med</stitle><addtitle>Clin Exp Med</addtitle><date>2023-10-01</date><risdate>2023</risdate><volume>23</volume><issue>6</issue><spage>2209</spage><epage>2220</epage><pages>2209-2220</pages><issn>1591-9528</issn><issn>1591-8890</issn><eissn>1591-9528</eissn><abstract>Papillary thyroid carcinoma (PTC) has a relatively good prognosis, yet there are some invasive PTC cases with worse clinicopathological features and poor outcome. Cancer-associated fibroblasts (CAFs) play an important role in cancer invasion and metastasis. This study aimed to investigate the expression of marker proteins of CAFs in PTC and their correlations with clinicopathological features through immunohistochemistry. The medical records of 125 PTC patients were reviewed in this study, whose specimens were retrieved for immunohistochemistry. Four CAFs marker proteins, FAP fibroblast activated protein (FAP), α-smooth muscle actin (α-SMA), Vimentin and platelet-derived growth factor receptor-α(PDGFR-α), were stained and scored. Then, statistical analyses were performed. The immunoreactivity scores of FAP and α-SMA correlated with tumor size, BRAF mutation, extrathyroidal, invasion, pathological subtype, lymph node metastasis and ATA risk stratification. Moreover, binary logistic regression analysis and receiver operating characteristic curves showed that high FAP and α-SMA immunoreactivity scores were risk factors for extrathyroidal invasion, BRAF mutation, multi-focality and lymph node metastasis (especially N1b) with good sensitivity and accuracy in prediction. A better performance was found in FAP than α-SMA. Strong expressions of CAFs were risk factors for worse thyroid cancer clinicopathological features. FAP was the better CAFs marker for PTC.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>36715834</pmid><doi>10.1007/s10238-023-00998-2</doi><tpages>12</tpages></addata></record> |
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| subjects | Actin Clinical Practice Fibroblasts Hematology Immunohistochemistry Internal Medicine Lymph nodes Lymphatic system Medical records Medicine Medicine & Public Health Metastases Metastasis Mutation Oncology Papillary thyroid carcinoma Platelet-derived growth factor Platelet-derived growth factor receptors Risk factors Smooth muscle Statistical analysis Thyroid cancer Vimentin |
| title | Cancer-associated fibroblasts in papillary thyroid carcinoma |
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