Kinetics of Covid-19 antibodies in terms of titre and duration among healthcare workers: A longitudinal study
Background Most individuals with Covid-19 infection develop antibodies specific to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the dynamics of these antibodies is variable and not well-studied. We aimed to determine the titres of naturally acquired antibodies over a 12...
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| Veröffentlicht in: | The National medical journal of India 2022-07, Vol.35 (4), p.201-205, Article 201 |
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| creator | Goenka, Mahesh Kumar Goenka, Usha Patil, Vikram Uttam Das, Sudipta Sekhar Afzalpurkar, Shivaraj Jajodia, Surabhi Mukherjee, Muhuya Shah, Bhavik Bharat Moitra, Saibal |
| description | Background Most individuals with Covid-19 infection develop antibodies specific to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the dynamics of these antibodies is variable and not well-studied. We aimed to determine the titres of naturally acquired antibodies over a 12-week follow-up. Methods We recruited healthcare workers who had tested positive on a specific quantitative reverse transcription-polymerase chain reaction (qRT-PCR) for SARS-CoV-2, and then tested for the presence of immunoglobulin G (IgG) antibody against the same virus at baseline and again at 6 and 12 weeks. The antibody titre was determined by a semi-quantitative assay based on signal/cut-off ratio. Healthcare workers with antibody positivity were divided into those with high titre (ratio ≥12) and low titre ( |
| doi_str_mv | 10.25259/NMJI_109_21 |
| format | Article |
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However, the dynamics of these antibodies is variable and not well-studied. We aimed to determine the titres of naturally acquired antibodies over a 12-week follow-up. Methods We recruited healthcare workers who had tested positive on a specific quantitative reverse transcription-polymerase chain reaction (qRT-PCR) for SARS-CoV-2, and then tested for the presence of immunoglobulin G (IgG) antibody against the same virus at baseline and again at 6 and 12 weeks. The antibody titre was determined by a semi-quantitative assay based on signal/cut-off ratio. Healthcare workers with antibody positivity were divided into those with high titre (ratio ≥12) and low titre (<12). Their demographic details and risk factors were surveyed through a Google form and analysed in relation to the antibody titres at three time-points. Results Of the 286 healthcare workers, 10.48% had high antibody titres. Healthcare workers who had tested positive by qRT-PCR and those who had received the Bacille Calmette-Guérin (BCG) vaccination or other immune-boosters had a higher frequency of high antibody titres. While there was a significant decline in antibody titres at 6 and 12 weeks, 87.46% of individuals positive for IgG antibody persisted to have the antibody even at 12 weeks. Conclusion Healthcare workers who tested positive for SARS-CoV-2 on qRT-PCR had a high positivity for the specific antibody, which continued to express in them even at 12 weeks. Further follow-up is likely to enhance our understanding of antibody kinetics following SARS-CoV-2 infection.</description><identifier>ISSN: 0970-258X</identifier><identifier>EISSN: 0970-258X</identifier><identifier>DOI: 10.25259/NMJI_109_21</identifier><identifier>PMID: 36715043</identifier><language>eng</language><publisher>India</publisher><subject>Antibodies, Viral ; COVID-19 - diagnosis ; COVID-19 - epidemiology ; Health Personnel ; Humans ; Longitudinal Studies ; Risk Factors ; SARS-CoV-2</subject><ispartof>The National medical journal of India, 2022-07, Vol.35 (4), p.201-205, Article 201</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c286t-d07a1b175aee3101778577c56288f21cfdb54373dedd090452688e798ca4d6b33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36715043$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Goenka, Mahesh Kumar</creatorcontrib><creatorcontrib>Goenka, Usha</creatorcontrib><creatorcontrib>Patil, Vikram Uttam</creatorcontrib><creatorcontrib>Das, Sudipta Sekhar</creatorcontrib><creatorcontrib>Afzalpurkar, Shivaraj</creatorcontrib><creatorcontrib>Jajodia, Surabhi</creatorcontrib><creatorcontrib>Mukherjee, Muhuya</creatorcontrib><creatorcontrib>Shah, Bhavik Bharat</creatorcontrib><creatorcontrib>Moitra, Saibal</creatorcontrib><title>Kinetics of Covid-19 antibodies in terms of titre and duration among healthcare workers: A longitudinal study</title><title>The National medical journal of India</title><addtitle>Natl Med J India</addtitle><description>Background Most individuals with Covid-19 infection develop antibodies specific to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the dynamics of these antibodies is variable and not well-studied. We aimed to determine the titres of naturally acquired antibodies over a 12-week follow-up. Methods We recruited healthcare workers who had tested positive on a specific quantitative reverse transcription-polymerase chain reaction (qRT-PCR) for SARS-CoV-2, and then tested for the presence of immunoglobulin G (IgG) antibody against the same virus at baseline and again at 6 and 12 weeks. The antibody titre was determined by a semi-quantitative assay based on signal/cut-off ratio. Healthcare workers with antibody positivity were divided into those with high titre (ratio ≥12) and low titre (<12). Their demographic details and risk factors were surveyed through a Google form and analysed in relation to the antibody titres at three time-points. Results Of the 286 healthcare workers, 10.48% had high antibody titres. Healthcare workers who had tested positive by qRT-PCR and those who had received the Bacille Calmette-Guérin (BCG) vaccination or other immune-boosters had a higher frequency of high antibody titres. While there was a significant decline in antibody titres at 6 and 12 weeks, 87.46% of individuals positive for IgG antibody persisted to have the antibody even at 12 weeks. Conclusion Healthcare workers who tested positive for SARS-CoV-2 on qRT-PCR had a high positivity for the specific antibody, which continued to express in them even at 12 weeks. Further follow-up is likely to enhance our understanding of antibody kinetics following SARS-CoV-2 infection.</description><subject>Antibodies, Viral</subject><subject>COVID-19 - diagnosis</subject><subject>COVID-19 - epidemiology</subject><subject>Health Personnel</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Risk Factors</subject><subject>SARS-CoV-2</subject><issn>0970-258X</issn><issn>0970-258X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkDtPwzAURi0EouWxMSOPDAT8iGOHrap4vxaQ2CInvqGGJC62A-q_J2oL6nSvdI6-4SB0RMkZE0zk50-Pd7cFJXnB6BYak1yShAn1tr3xj9BeCB-EZJwKuotGPJNUkJSPUXtvO4i2CtjVeOq-rUlojnUXbemMhYBthyP4dsmjjR4GaLDpvY7WdVi3rnvHM9BNnFV6oD_Of4IPF3iCmwHZ2Bvb6QaH4VkcoJ1aNwEO13cfvV5dvkxvkofn69vp5CGpmMpiYojUtKRSaABOCZVSCSkrkTGlakar2pQi5ZIbMIbkJBUsUwpkriqdmqzkfB-drHbn3n31EGLR2lBB0-gOXB8KJiUlSqVCDurpSq28C8FDXcy9bbVfDEmLZeBiI_CgH6-X-7IF8y__FeW_4tV2xg</recordid><startdate>20220701</startdate><enddate>20220701</enddate><creator>Goenka, Mahesh Kumar</creator><creator>Goenka, Usha</creator><creator>Patil, Vikram Uttam</creator><creator>Das, Sudipta Sekhar</creator><creator>Afzalpurkar, Shivaraj</creator><creator>Jajodia, Surabhi</creator><creator>Mukherjee, Muhuya</creator><creator>Shah, Bhavik Bharat</creator><creator>Moitra, Saibal</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20220701</creationdate><title>Kinetics of Covid-19 antibodies in terms of titre and duration among healthcare workers: A longitudinal study</title><author>Goenka, Mahesh Kumar ; Goenka, Usha ; Patil, Vikram Uttam ; Das, Sudipta Sekhar ; Afzalpurkar, Shivaraj ; Jajodia, Surabhi ; Mukherjee, Muhuya ; Shah, Bhavik Bharat ; Moitra, Saibal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c286t-d07a1b175aee3101778577c56288f21cfdb54373dedd090452688e798ca4d6b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Antibodies, Viral</topic><topic>COVID-19 - diagnosis</topic><topic>COVID-19 - epidemiology</topic><topic>Health Personnel</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Risk Factors</topic><topic>SARS-CoV-2</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goenka, Mahesh Kumar</creatorcontrib><creatorcontrib>Goenka, Usha</creatorcontrib><creatorcontrib>Patil, Vikram Uttam</creatorcontrib><creatorcontrib>Das, Sudipta Sekhar</creatorcontrib><creatorcontrib>Afzalpurkar, Shivaraj</creatorcontrib><creatorcontrib>Jajodia, Surabhi</creatorcontrib><creatorcontrib>Mukherjee, Muhuya</creatorcontrib><creatorcontrib>Shah, Bhavik Bharat</creatorcontrib><creatorcontrib>Moitra, Saibal</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The National medical journal of India</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goenka, Mahesh Kumar</au><au>Goenka, Usha</au><au>Patil, Vikram Uttam</au><au>Das, Sudipta Sekhar</au><au>Afzalpurkar, Shivaraj</au><au>Jajodia, Surabhi</au><au>Mukherjee, Muhuya</au><au>Shah, Bhavik Bharat</au><au>Moitra, Saibal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Kinetics of Covid-19 antibodies in terms of titre and duration among healthcare workers: A longitudinal study</atitle><jtitle>The National medical journal of India</jtitle><addtitle>Natl Med J India</addtitle><date>2022-07-01</date><risdate>2022</risdate><volume>35</volume><issue>4</issue><spage>201</spage><epage>205</epage><pages>201-205</pages><artnum>201</artnum><issn>0970-258X</issn><eissn>0970-258X</eissn><abstract>Background Most individuals with Covid-19 infection develop antibodies specific to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the dynamics of these antibodies is variable and not well-studied. We aimed to determine the titres of naturally acquired antibodies over a 12-week follow-up. Methods We recruited healthcare workers who had tested positive on a specific quantitative reverse transcription-polymerase chain reaction (qRT-PCR) for SARS-CoV-2, and then tested for the presence of immunoglobulin G (IgG) antibody against the same virus at baseline and again at 6 and 12 weeks. The antibody titre was determined by a semi-quantitative assay based on signal/cut-off ratio. Healthcare workers with antibody positivity were divided into those with high titre (ratio ≥12) and low titre (<12). Their demographic details and risk factors were surveyed through a Google form and analysed in relation to the antibody titres at three time-points. Results Of the 286 healthcare workers, 10.48% had high antibody titres. Healthcare workers who had tested positive by qRT-PCR and those who had received the Bacille Calmette-Guérin (BCG) vaccination or other immune-boosters had a higher frequency of high antibody titres. While there was a significant decline in antibody titres at 6 and 12 weeks, 87.46% of individuals positive for IgG antibody persisted to have the antibody even at 12 weeks. Conclusion Healthcare workers who tested positive for SARS-CoV-2 on qRT-PCR had a high positivity for the specific antibody, which continued to express in them even at 12 weeks. Further follow-up is likely to enhance our understanding of antibody kinetics following SARS-CoV-2 infection.</abstract><cop>India</cop><pmid>36715043</pmid><doi>10.25259/NMJI_109_21</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Antibodies, Viral COVID-19 - diagnosis COVID-19 - epidemiology Health Personnel Humans Longitudinal Studies Risk Factors SARS-CoV-2 |
| title | Kinetics of Covid-19 antibodies in terms of titre and duration among healthcare workers: A longitudinal study |
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