Filtered Cerebrospinal Fluid From Patients With Amyotrophic Lateral Sclerosis Displays an Altered Proteome and Affects Motor Phenotype in a Mouse Model

Cerebrospinal fluid (CSF) has been implicated in amyotrophic lateral sclerosis (ALS) due to its ability to spread inflammatory proteins throughout the nervous system. We hypothesized that filtration of the CSF could remove pathogenic proteins and prevent them from altering motor phenotypes in a mous...

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Veröffentlicht in:	Curēus (Palo Alto, CA) CA), 2022-12, Vol.14 (12), p.e32980-e32980
Hauptverfasser:	Venkatraman, Vishal, Filiano, Anthony J, Xu, Li, Collins, Leonard, Luo, Emily, Ripple, Katelyn M, de Castro, George C, Boua, Jane-Valeriane K, Marius, Choiselle, Giamberardino, Charles, Lad, Shivanand P, Islam Williams, Taufika, Bereman, Michael S, Bedlack, Richard S
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyotrophic lateral sclerosis Biobanks Cerebrospinal fluid Guillain-Barre syndrome Mass spectrometry Medical research Patients Peptides Proteins Proteomics Review boards Scientific imaging
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