Thrombocytopenia Following Perceval Sutureless Aortic Valve Replacement in Asian Patients
Background: This study analyzed the safety and performance of the Perceval valve for aortic valve replacement (AVR) in patients at 1 year after undergoing aortic stenosis (AS) treatment, and its effect on significant declines in the platelet count during the immediate postoperative period.Methods an...
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| Veröffentlicht in: | Circulation Journal 2024/03/25, Vol.88(4), pp.549-558 |
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| creator | Nakayama, Taisuke Nakamura, Yoshitsugu Shikata, Fumiaki Ushijima, Masaki Yasumoto, Yuto Yoshiyama, Daiki Kuroda, Miho Sawa, Shintaro Tsuruta, Ryo Furutachi, Akira Narita, Takuya Ito, Yujiro |
| description | Background: This study analyzed the safety and performance of the Perceval valve for aortic valve replacement (AVR) in patients at 1 year after undergoing aortic stenosis (AS) treatment, and its effect on significant declines in the platelet count during the immediate postoperative period.Methods and Results: Data were collected retrospectively for the initial 121 patients (median age 77 years; 47.1% females) who underwent Perceval sutureless AVR between May 2019 and July 2022. Implantation was successful in all (100%), with median cross-clamp and CPB times of 59 and 100 min, respectively. Postoperative thrombocytopenia (platelet count 80 years), preoperative low platelet count ( |
| doi_str_mv | 10.1253/circj.CJ-22-0587 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2771083963</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2771083963</sourcerecordid><originalsourceid>FETCH-LOGICAL-c554t-b4fd98e3abc21e2416ded798c124e3bdda78b94f3b08dd04d160cc02d38a4d4a3</originalsourceid><addsrcrecordid>eNpFkElPwzAQRi0EYr9zQj5yCXhLYh-rirIICcQmcbIcewqunLjYCYh_T0sLXGZGo_d9h4fQESWnlJX8zPpkZ6fj64KxgpSy3kC7lIu6EJKRzZ-7KpQUfAft5TwjhClSqm20w6uaKCX5Lnp5fEuxbaL96uMcOm_wJIYQP333iu8gWfgwAT8M_ZAgQM54FFPvLX424QPwPcyDsdBC12Pf4VH2psN3pveLRz5AW1MTMhyu9z56mpw_ji-Lm9uLq_HoprBlKfqiEVOnJHDTWEaBCVo5cLWSljIBvHHO1LJRYsobIp0jwtGKWEuY49IIJwzfRyer3nmK7wPkXrc-WwjBdBCHrFldUyK5qvgCJSvUpphzgqmeJ9-a9KUp0Uuh-keoHl9rxvRS6CJyvG4fmhbcX-DX4AKYrIBZ7s0r_AFm6SnAulFKLZbjv_kfeDNJQ8e_Adjcjb4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2771083963</pqid></control><display><type>article</type><title>Thrombocytopenia Following Perceval Sutureless Aortic Valve Replacement in Asian Patients</title><source>J-STAGE Free</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Nakayama, Taisuke ; Nakamura, Yoshitsugu ; Shikata, Fumiaki ; Ushijima, Masaki ; Yasumoto, Yuto ; Yoshiyama, Daiki ; Kuroda, Miho ; Sawa, Shintaro ; Tsuruta, Ryo ; Furutachi, Akira ; Narita, Takuya ; Ito, Yujiro</creator><creatorcontrib>Nakayama, Taisuke ; Nakamura, Yoshitsugu ; Shikata, Fumiaki ; Ushijima, Masaki ; Yasumoto, Yuto ; Yoshiyama, Daiki ; Kuroda, Miho ; Sawa, Shintaro ; Tsuruta, Ryo ; Furutachi, Akira ; Narita, Takuya ; Ito, Yujiro</creatorcontrib><description>Background: This study analyzed the safety and performance of the Perceval valve for aortic valve replacement (AVR) in patients at 1 year after undergoing aortic stenosis (AS) treatment, and its effect on significant declines in the platelet count during the immediate postoperative period.Methods and Results: Data were collected retrospectively for the initial 121 patients (median age 77 years; 47.1% females) who underwent Perceval sutureless AVR between May 2019 and July 2022. Implantation was successful in all (100%), with median cross-clamp and CPB times of 59 and 100 min, respectively. Postoperative thrombocytopenia (platelet count <50×103/μL) was noted in 80 (66.1%) patients. Multivariate analysis showed advanced age (>80 years), preoperative low platelet count (<200×103/μL), and a sternotomy approach as significant risk factors for postoperative thrombocytopenia. One (0.8%) patient died within 30 days after the procedure. The 2-year site-reported event rate was 14% (n=17) for all-cause mortality, 0.8% (n=1) for cardiac mortality, 4.1% (n=5) for stroke, and 1.7% (n=2) for endocarditis and valve-related reoperation; there were no instances of paravalvular leakage or structural valve deterioration.Conclusions: Thrombocytopenia was common after Perceval sutureless AVR, although its impact was not significant. Although Perceval sutureless AVR was found to be a safe and effective option, preoperative assessment of potential bleeding should be performed and the Perceval valve should not be used for patients with a high bleeding risk.</description><identifier>ISSN: 1346-9843</identifier><identifier>ISSN: 1347-4820</identifier><identifier>EISSN: 1347-4820</identifier><identifier>DOI: 10.1253/circj.CJ-22-0587</identifier><identifier>PMID: 36709983</identifier><language>eng</language><publisher>Japan: The Japanese Circulation Society</publisher><subject>Aged ; Aged, 80 and over ; Aortic Valve - surgery ; Aortic Valve Stenosis ; Bioprosthesis - adverse effects ; Female ; Heart Valve Prosthesis - adverse effects ; Heart Valve Prosthesis Implantation ; Humans ; Male ; Perceval valve ; Prosthesis Design ; Retrospective Studies ; Sutureless aortic valve replacement ; Thrombocytopenia ; Thrombocytopenia - etiology ; Treatment Outcome</subject><ispartof>Circulation Journal, 2024/03/25, Vol.88(4), pp.549-558</ispartof><rights>2024, THE JAPANESE CIRCULATION SOCIETY</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c554t-b4fd98e3abc21e2416ded798c124e3bdda78b94f3b08dd04d160cc02d38a4d4a3</citedby><cites>FETCH-LOGICAL-c554t-b4fd98e3abc21e2416ded798c124e3bdda78b94f3b08dd04d160cc02d38a4d4a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36709983$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakayama, Taisuke</creatorcontrib><creatorcontrib>Nakamura, Yoshitsugu</creatorcontrib><creatorcontrib>Shikata, Fumiaki</creatorcontrib><creatorcontrib>Ushijima, Masaki</creatorcontrib><creatorcontrib>Yasumoto, Yuto</creatorcontrib><creatorcontrib>Yoshiyama, Daiki</creatorcontrib><creatorcontrib>Kuroda, Miho</creatorcontrib><creatorcontrib>Sawa, Shintaro</creatorcontrib><creatorcontrib>Tsuruta, Ryo</creatorcontrib><creatorcontrib>Furutachi, Akira</creatorcontrib><creatorcontrib>Narita, Takuya</creatorcontrib><creatorcontrib>Ito, Yujiro</creatorcontrib><title>Thrombocytopenia Following Perceval Sutureless Aortic Valve Replacement in Asian Patients</title><title>Circulation Journal</title><addtitle>Circ J</addtitle><description>Background: This study analyzed the safety and performance of the Perceval valve for aortic valve replacement (AVR) in patients at 1 year after undergoing aortic stenosis (AS) treatment, and its effect on significant declines in the platelet count during the immediate postoperative period.Methods and Results: Data were collected retrospectively for the initial 121 patients (median age 77 years; 47.1% females) who underwent Perceval sutureless AVR between May 2019 and July 2022. Implantation was successful in all (100%), with median cross-clamp and CPB times of 59 and 100 min, respectively. Postoperative thrombocytopenia (platelet count <50×103/μL) was noted in 80 (66.1%) patients. Multivariate analysis showed advanced age (>80 years), preoperative low platelet count (<200×103/μL), and a sternotomy approach as significant risk factors for postoperative thrombocytopenia. One (0.8%) patient died within 30 days after the procedure. The 2-year site-reported event rate was 14% (n=17) for all-cause mortality, 0.8% (n=1) for cardiac mortality, 4.1% (n=5) for stroke, and 1.7% (n=2) for endocarditis and valve-related reoperation; there were no instances of paravalvular leakage or structural valve deterioration.Conclusions: Thrombocytopenia was common after Perceval sutureless AVR, although its impact was not significant. Although Perceval sutureless AVR was found to be a safe and effective option, preoperative assessment of potential bleeding should be performed and the Perceval valve should not be used for patients with a high bleeding risk.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aortic Valve - surgery</subject><subject>Aortic Valve Stenosis</subject><subject>Bioprosthesis - adverse effects</subject><subject>Female</subject><subject>Heart Valve Prosthesis - adverse effects</subject><subject>Heart Valve Prosthesis Implantation</subject><subject>Humans</subject><subject>Male</subject><subject>Perceval valve</subject><subject>Prosthesis Design</subject><subject>Retrospective Studies</subject><subject>Sutureless aortic valve replacement</subject><subject>Thrombocytopenia</subject><subject>Thrombocytopenia - etiology</subject><subject>Treatment Outcome</subject><issn>1346-9843</issn><issn>1347-4820</issn><issn>1347-4820</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkElPwzAQRi0EYr9zQj5yCXhLYh-rirIICcQmcbIcewqunLjYCYh_T0sLXGZGo_d9h4fQESWnlJX8zPpkZ6fj64KxgpSy3kC7lIu6EJKRzZ-7KpQUfAft5TwjhClSqm20w6uaKCX5Lnp5fEuxbaL96uMcOm_wJIYQP333iu8gWfgwAT8M_ZAgQM54FFPvLX424QPwPcyDsdBC12Pf4VH2psN3pveLRz5AW1MTMhyu9z56mpw_ji-Lm9uLq_HoprBlKfqiEVOnJHDTWEaBCVo5cLWSljIBvHHO1LJRYsobIp0jwtGKWEuY49IIJwzfRyer3nmK7wPkXrc-WwjBdBCHrFldUyK5qvgCJSvUpphzgqmeJ9-a9KUp0Uuh-keoHl9rxvRS6CJyvG4fmhbcX-DX4AKYrIBZ7s0r_AFm6SnAulFKLZbjv_kfeDNJQ8e_Adjcjb4</recordid><startdate>20240325</startdate><enddate>20240325</enddate><creator>Nakayama, Taisuke</creator><creator>Nakamura, Yoshitsugu</creator><creator>Shikata, Fumiaki</creator><creator>Ushijima, Masaki</creator><creator>Yasumoto, Yuto</creator><creator>Yoshiyama, Daiki</creator><creator>Kuroda, Miho</creator><creator>Sawa, Shintaro</creator><creator>Tsuruta, Ryo</creator><creator>Furutachi, Akira</creator><creator>Narita, Takuya</creator><creator>Ito, Yujiro</creator><general>The Japanese Circulation Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20240325</creationdate><title>Thrombocytopenia Following Perceval Sutureless Aortic Valve Replacement in Asian Patients</title><author>Nakayama, Taisuke ; Nakamura, Yoshitsugu ; Shikata, Fumiaki ; Ushijima, Masaki ; Yasumoto, Yuto ; Yoshiyama, Daiki ; Kuroda, Miho ; Sawa, Shintaro ; Tsuruta, Ryo ; Furutachi, Akira ; Narita, Takuya ; Ito, Yujiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c554t-b4fd98e3abc21e2416ded798c124e3bdda78b94f3b08dd04d160cc02d38a4d4a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aortic Valve - surgery</topic><topic>Aortic Valve Stenosis</topic><topic>Bioprosthesis - adverse effects</topic><topic>Female</topic><topic>Heart Valve Prosthesis - adverse effects</topic><topic>Heart Valve Prosthesis Implantation</topic><topic>Humans</topic><topic>Male</topic><topic>Perceval valve</topic><topic>Prosthesis Design</topic><topic>Retrospective Studies</topic><topic>Sutureless aortic valve replacement</topic><topic>Thrombocytopenia</topic><topic>Thrombocytopenia - etiology</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakayama, Taisuke</creatorcontrib><creatorcontrib>Nakamura, Yoshitsugu</creatorcontrib><creatorcontrib>Shikata, Fumiaki</creatorcontrib><creatorcontrib>Ushijima, Masaki</creatorcontrib><creatorcontrib>Yasumoto, Yuto</creatorcontrib><creatorcontrib>Yoshiyama, Daiki</creatorcontrib><creatorcontrib>Kuroda, Miho</creatorcontrib><creatorcontrib>Sawa, Shintaro</creatorcontrib><creatorcontrib>Tsuruta, Ryo</creatorcontrib><creatorcontrib>Furutachi, Akira</creatorcontrib><creatorcontrib>Narita, Takuya</creatorcontrib><creatorcontrib>Ito, Yujiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakayama, Taisuke</au><au>Nakamura, Yoshitsugu</au><au>Shikata, Fumiaki</au><au>Ushijima, Masaki</au><au>Yasumoto, Yuto</au><au>Yoshiyama, Daiki</au><au>Kuroda, Miho</au><au>Sawa, Shintaro</au><au>Tsuruta, Ryo</au><au>Furutachi, Akira</au><au>Narita, Takuya</au><au>Ito, Yujiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thrombocytopenia Following Perceval Sutureless Aortic Valve Replacement in Asian Patients</atitle><jtitle>Circulation Journal</jtitle><addtitle>Circ J</addtitle><date>2024-03-25</date><risdate>2024</risdate><volume>88</volume><issue>4</issue><spage>549</spage><epage>558</epage><pages>549-558</pages><artnum>CJ-22-0587</artnum><issn>1346-9843</issn><issn>1347-4820</issn><eissn>1347-4820</eissn><abstract>Background: This study analyzed the safety and performance of the Perceval valve for aortic valve replacement (AVR) in patients at 1 year after undergoing aortic stenosis (AS) treatment, and its effect on significant declines in the platelet count during the immediate postoperative period.Methods and Results: Data were collected retrospectively for the initial 121 patients (median age 77 years; 47.1% females) who underwent Perceval sutureless AVR between May 2019 and July 2022. Implantation was successful in all (100%), with median cross-clamp and CPB times of 59 and 100 min, respectively. Postoperative thrombocytopenia (platelet count <50×103/μL) was noted in 80 (66.1%) patients. Multivariate analysis showed advanced age (>80 years), preoperative low platelet count (<200×103/μL), and a sternotomy approach as significant risk factors for postoperative thrombocytopenia. One (0.8%) patient died within 30 days after the procedure. The 2-year site-reported event rate was 14% (n=17) for all-cause mortality, 0.8% (n=1) for cardiac mortality, 4.1% (n=5) for stroke, and 1.7% (n=2) for endocarditis and valve-related reoperation; there were no instances of paravalvular leakage or structural valve deterioration.Conclusions: Thrombocytopenia was common after Perceval sutureless AVR, although its impact was not significant. Although Perceval sutureless AVR was found to be a safe and effective option, preoperative assessment of potential bleeding should be performed and the Perceval valve should not be used for patients with a high bleeding risk.</abstract><cop>Japan</cop><pub>The Japanese Circulation Society</pub><pmid>36709983</pmid><doi>10.1253/circj.CJ-22-0587</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aged, 80 and over Aortic Valve - surgery Aortic Valve Stenosis Bioprosthesis - adverse effects Female Heart Valve Prosthesis - adverse effects Heart Valve Prosthesis Implantation Humans Male Perceval valve Prosthesis Design Retrospective Studies Sutureless aortic valve replacement Thrombocytopenia Thrombocytopenia - etiology Treatment Outcome |
| title | Thrombocytopenia Following Perceval Sutureless Aortic Valve Replacement in Asian Patients |
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