Reproducibility of low-level residual myeloma immunoglobulin detection using ultra-deep sequencing

•Detection of low-level myeloma residual disease using deep sequencing of clonal immunoglobulin rearrangements is reproducible in a controlled setup using the LymphoTrack assay.•Residual myeloma cells can consistently be quantified by employing an internal deoxyribonucleic acid control.•The nontechn...

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Veröffentlicht in:	Experimental hematology 2023-03, Vol.119-120, p.14-20
Hauptverfasser:	Cédile, Oriane, Hansen, Marcus Høy, Dahlmann, Sara Kamuk, Kristensen, Thomas Kielsgaard, Abildgaard, Niels, Nyvold, Charlotte Guldborg
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA High-Throughput Nucleotide Sequencing Humans Multiple Myeloma - diagnosis Multiple Myeloma - genetics Multiple Myeloma - pathology Neoplasm, Residual - diagnosis Neoplasm, Residual - genetics Reproducibility of Results
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