Enhancement of hypericin nanoparticle-mediated sonoinduced disruption of biofilm and persister cells of Streptococcus mutans by dermcidin-derived peptide DCD-1L
•The amount of ROS produced by HypNP-DCD-1 L with the ultrasound waves increased 4.2-fold.•The combination of ultrasound waves with HypNP-DCD-1 L significantly degraded S. mutans biofilm by 5.1 log10 CFU/mL.•HypNP-DCD-1L-mediated aSDT can efficiently reduce the pathogenicity of S. mutans via downreg...
Gespeichert in:
| Veröffentlicht in: | Photodiagnosis and photodynamic therapy 2023-03, Vol.41, p.103308-103308, Article 103308 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 103308 |
|---|---|
| container_issue | |
| container_start_page | 103308 |
| container_title | Photodiagnosis and photodynamic therapy |
| container_volume | 41 |
| creator | Pourhajibagher, Maryam Parker, Steven Pourakbari, Babak Valian, Nasrin Keshavarz Raoofian, Reza Bahador, Abbas |
| description | •The amount of ROS produced by HypNP-DCD-1 L with the ultrasound waves increased 4.2-fold.•The combination of ultrasound waves with HypNP-DCD-1 L significantly degraded S. mutans biofilm by 5.1 log10 CFU/mL.•HypNP-DCD-1L-mediated aSDT can efficiently reduce the pathogenicity of S. mutans via downregulating the biofilm-associated genes.•aSDT using HypNP-DCD-1 L reduce the persistence phenotype by suppressing the expression of genes associated persister cells formation.
Streptococcus mutans is considered a major significant contributor to dental caries and its effective removal is difficult due to the formation of biofilm. Therefore, the development of adjuvant therapeutic strategies with anti-biofilm properties is a promising approach. In the present study, we examined the effect of dermcidin-derived peptide DCD-1 L on the antibacterial activity of hypericin nanoparticle (HypNP)-mediated antimicrobial sonodynamic therapy (aSDT) against persister cells growing- and biofilm cultures of S. mutans.
Following synthesis and confirmation of HypNP, the fractional inhibitory concentration (FIC) index of HypNP and DCD-1 L was determined by checkerboard assay. Cellular uptake of HypNP-DCD-1 L and generation of endogenous reactive oxygen species (ROS) were assessed and followed by the determination of antimicrobial sonoactivity of HypNP-DCD-1 L against persister cells growing- and biofilm cultures of S. mutans. The water-insoluble extracellular polysaccharide (EPS) and expression of the gtfD, comDE, and smuT genes were then evaluated in persister cells growing- and biofilm cultures of S. mutans.
There was a synergistic activity in the combination of HypNP and DCD-1 L against S. mutans with an FIC index value of 0.37. The HypNP-DCD-1L-mediated aSDT also displayed the highest cellular uptake and endogenous ROS generation by bacterial cells. When biofilm and persister cells of S. mutans were treated with HypNP-DCD-1 L and subsequently exposed to ultrasound waves, 5.1 log and 3.8 log reductions, respectively, in bacterial numbers were observed (P |
| doi_str_mv | 10.1016/j.pdpdt.2023.103308 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2770478408</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1572100023000364</els_id><sourcerecordid>2770478408</sourcerecordid><originalsourceid>FETCH-LOGICAL-c359t-e8a618d03e36ffbd86ab5b2545776e073b41b9bbf34ee2afe13ba5d4a679c3973</originalsourceid><addsrcrecordid>eNp9kc1u1DAUhS1E1ZbSJ0BCXrLJYMdJnCxYoGn5kUbqAlhb_rlR7yixg-1UmrfhUXGYwpKVj-xzzrX9EfKGsx1nvHt_3C1ucXlXs1qUHSFY_4Jc816KireDfFl0K-uKM8auyKuUjoyJZmDNJbkSnWQD4_Ka_Lr3j9pbmMFnGkb6eFogokVPvfZh0TGjnaCawaHO4GgKPqB3qy3aYYrrkjH4LWkwjDjNVHtHS0fClCFSC9OUtuNvOcKSgw3WronOa9Y-UXOiDuJs0aGvisIn2MKl0wG9299V_PCaXIx6SnD7vN6QH5_uv--_VIeHz1_3Hw-VFe2QK-h1x3vHBIhuHI3rO21aU7dNK2UHTArTcDMYM4oGoNYjcGF06xrdycGKQYob8u7cu8Twc4WU1Yxpu732ENakailZI_uG9cUqzlYbQ0oRRrVEnHU8Kc7UhkYd1R80akOjzmhK6u3zgNWU7_yX-cuiGD6cDVCe-YQQVbIIhY3DCDYrF_C_A34D7sCk0w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2770478408</pqid></control><display><type>article</type><title>Enhancement of hypericin nanoparticle-mediated sonoinduced disruption of biofilm and persister cells of Streptococcus mutans by dermcidin-derived peptide DCD-1L</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Pourhajibagher, Maryam ; Parker, Steven ; Pourakbari, Babak ; Valian, Nasrin Keshavarz ; Raoofian, Reza ; Bahador, Abbas</creator><creatorcontrib>Pourhajibagher, Maryam ; Parker, Steven ; Pourakbari, Babak ; Valian, Nasrin Keshavarz ; Raoofian, Reza ; Bahador, Abbas</creatorcontrib><description>•The amount of ROS produced by HypNP-DCD-1 L with the ultrasound waves increased 4.2-fold.•The combination of ultrasound waves with HypNP-DCD-1 L significantly degraded S. mutans biofilm by 5.1 log10 CFU/mL.•HypNP-DCD-1L-mediated aSDT can efficiently reduce the pathogenicity of S. mutans via downregulating the biofilm-associated genes.•aSDT using HypNP-DCD-1 L reduce the persistence phenotype by suppressing the expression of genes associated persister cells formation.
Streptococcus mutans is considered a major significant contributor to dental caries and its effective removal is difficult due to the formation of biofilm. Therefore, the development of adjuvant therapeutic strategies with anti-biofilm properties is a promising approach. In the present study, we examined the effect of dermcidin-derived peptide DCD-1 L on the antibacterial activity of hypericin nanoparticle (HypNP)-mediated antimicrobial sonodynamic therapy (aSDT) against persister cells growing- and biofilm cultures of S. mutans.
Following synthesis and confirmation of HypNP, the fractional inhibitory concentration (FIC) index of HypNP and DCD-1 L was determined by checkerboard assay. Cellular uptake of HypNP-DCD-1 L and generation of endogenous reactive oxygen species (ROS) were assessed and followed by the determination of antimicrobial sonoactivity of HypNP-DCD-1 L against persister cells growing- and biofilm cultures of S. mutans. The water-insoluble extracellular polysaccharide (EPS) and expression of the gtfD, comDE, and smuT genes were then evaluated in persister cells growing- and biofilm cultures of S. mutans.
There was a synergistic activity in the combination of HypNP and DCD-1 L against S. mutans with an FIC index value of 0.37. The HypNP-DCD-1L-mediated aSDT also displayed the highest cellular uptake and endogenous ROS generation by bacterial cells. When biofilm and persister cells of S. mutans were treated with HypNP-DCD-1 L and subsequently exposed to ultrasound waves, 5.1 log and 3.8 log reductions, respectively, in bacterial numbers were observed (P<0.05). According to the data, EPS in both persister cells growing- and biofilm cultures of S. mutans were significantly decreased after exposure to the HypNP-DCD-1L-mediated aSDT (P<0.05). In addition, the quantitative real-time PCR data illustrated the high level of similarities in very low-expression profiles of the gtfD before and after all treated groups for persister cells. While, following HypNP-DCD-1L-mediated aSDT treatment, the expression levels of gtfD, comDE, and smuT were significantly lower in treated persister cells growing- and biofilm cultures of S. mutans in comparison with control groups (P<0.05).
Combined, the results of this study indicate that ultrasound waves-activated HypNP-DCD-1 L can sonoinactivate S. mutans biofilms and persister cells, as well as reduce effectively pathogenicity potency of S. mutans. Hence, HypNP-DCD-1L-mediated aSDT may be proposed as a promising adjunctive therapeutic approach for dental caries.</description><identifier>ISSN: 1572-1000</identifier><identifier>EISSN: 1873-1597</identifier><identifier>DOI: 10.1016/j.pdpdt.2023.103308</identifier><identifier>PMID: 36709017</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Anti-Infective Agents - pharmacology ; Antimicrobial sonodynamic therapy ; Biofilms ; ComDE ; Dental Caries ; Dermcidins - metabolism ; Dermcidins - pharmacology ; GtfD ; Humans ; Persister cells ; Photochemotherapy - methods ; Photosensitizing Agents - pharmacology ; Reactive Oxygen Species - metabolism ; SmuT ; Streptococcus mutans</subject><ispartof>Photodiagnosis and photodynamic therapy, 2023-03, Vol.41, p.103308-103308, Article 103308</ispartof><rights>2023</rights><rights>Copyright © 2023. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-e8a618d03e36ffbd86ab5b2545776e073b41b9bbf34ee2afe13ba5d4a679c3973</citedby><cites>FETCH-LOGICAL-c359t-e8a618d03e36ffbd86ab5b2545776e073b41b9bbf34ee2afe13ba5d4a679c3973</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.pdpdt.2023.103308$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36709017$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pourhajibagher, Maryam</creatorcontrib><creatorcontrib>Parker, Steven</creatorcontrib><creatorcontrib>Pourakbari, Babak</creatorcontrib><creatorcontrib>Valian, Nasrin Keshavarz</creatorcontrib><creatorcontrib>Raoofian, Reza</creatorcontrib><creatorcontrib>Bahador, Abbas</creatorcontrib><title>Enhancement of hypericin nanoparticle-mediated sonoinduced disruption of biofilm and persister cells of Streptococcus mutans by dermcidin-derived peptide DCD-1L</title><title>Photodiagnosis and photodynamic therapy</title><addtitle>Photodiagnosis Photodyn Ther</addtitle><description>•The amount of ROS produced by HypNP-DCD-1 L with the ultrasound waves increased 4.2-fold.•The combination of ultrasound waves with HypNP-DCD-1 L significantly degraded S. mutans biofilm by 5.1 log10 CFU/mL.•HypNP-DCD-1L-mediated aSDT can efficiently reduce the pathogenicity of S. mutans via downregulating the biofilm-associated genes.•aSDT using HypNP-DCD-1 L reduce the persistence phenotype by suppressing the expression of genes associated persister cells formation.
Streptococcus mutans is considered a major significant contributor to dental caries and its effective removal is difficult due to the formation of biofilm. Therefore, the development of adjuvant therapeutic strategies with anti-biofilm properties is a promising approach. In the present study, we examined the effect of dermcidin-derived peptide DCD-1 L on the antibacterial activity of hypericin nanoparticle (HypNP)-mediated antimicrobial sonodynamic therapy (aSDT) against persister cells growing- and biofilm cultures of S. mutans.
Following synthesis and confirmation of HypNP, the fractional inhibitory concentration (FIC) index of HypNP and DCD-1 L was determined by checkerboard assay. Cellular uptake of HypNP-DCD-1 L and generation of endogenous reactive oxygen species (ROS) were assessed and followed by the determination of antimicrobial sonoactivity of HypNP-DCD-1 L against persister cells growing- and biofilm cultures of S. mutans. The water-insoluble extracellular polysaccharide (EPS) and expression of the gtfD, comDE, and smuT genes were then evaluated in persister cells growing- and biofilm cultures of S. mutans.
There was a synergistic activity in the combination of HypNP and DCD-1 L against S. mutans with an FIC index value of 0.37. The HypNP-DCD-1L-mediated aSDT also displayed the highest cellular uptake and endogenous ROS generation by bacterial cells. When biofilm and persister cells of S. mutans were treated with HypNP-DCD-1 L and subsequently exposed to ultrasound waves, 5.1 log and 3.8 log reductions, respectively, in bacterial numbers were observed (P<0.05). According to the data, EPS in both persister cells growing- and biofilm cultures of S. mutans were significantly decreased after exposure to the HypNP-DCD-1L-mediated aSDT (P<0.05). In addition, the quantitative real-time PCR data illustrated the high level of similarities in very low-expression profiles of the gtfD before and after all treated groups for persister cells. While, following HypNP-DCD-1L-mediated aSDT treatment, the expression levels of gtfD, comDE, and smuT were significantly lower in treated persister cells growing- and biofilm cultures of S. mutans in comparison with control groups (P<0.05).
Combined, the results of this study indicate that ultrasound waves-activated HypNP-DCD-1 L can sonoinactivate S. mutans biofilms and persister cells, as well as reduce effectively pathogenicity potency of S. mutans. Hence, HypNP-DCD-1L-mediated aSDT may be proposed as a promising adjunctive therapeutic approach for dental caries.</description><subject>Anti-Infective Agents - pharmacology</subject><subject>Antimicrobial sonodynamic therapy</subject><subject>Biofilms</subject><subject>ComDE</subject><subject>Dental Caries</subject><subject>Dermcidins - metabolism</subject><subject>Dermcidins - pharmacology</subject><subject>GtfD</subject><subject>Humans</subject><subject>Persister cells</subject><subject>Photochemotherapy - methods</subject><subject>Photosensitizing Agents - pharmacology</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>SmuT</subject><subject>Streptococcus mutans</subject><issn>1572-1000</issn><issn>1873-1597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAUhS1E1ZbSJ0BCXrLJYMdJnCxYoGn5kUbqAlhb_rlR7yixg-1UmrfhUXGYwpKVj-xzzrX9EfKGsx1nvHt_3C1ucXlXs1qUHSFY_4Jc816KireDfFl0K-uKM8auyKuUjoyJZmDNJbkSnWQD4_Ka_Lr3j9pbmMFnGkb6eFogokVPvfZh0TGjnaCawaHO4GgKPqB3qy3aYYrrkjH4LWkwjDjNVHtHS0fClCFSC9OUtuNvOcKSgw3WronOa9Y-UXOiDuJs0aGvisIn2MKl0wG9299V_PCaXIx6SnD7vN6QH5_uv--_VIeHz1_3Hw-VFe2QK-h1x3vHBIhuHI3rO21aU7dNK2UHTArTcDMYM4oGoNYjcGF06xrdycGKQYob8u7cu8Twc4WU1Yxpu732ENakailZI_uG9cUqzlYbQ0oRRrVEnHU8Kc7UhkYd1R80akOjzmhK6u3zgNWU7_yX-cuiGD6cDVCe-YQQVbIIhY3DCDYrF_C_A34D7sCk0w</recordid><startdate>202303</startdate><enddate>202303</enddate><creator>Pourhajibagher, Maryam</creator><creator>Parker, Steven</creator><creator>Pourakbari, Babak</creator><creator>Valian, Nasrin Keshavarz</creator><creator>Raoofian, Reza</creator><creator>Bahador, Abbas</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202303</creationdate><title>Enhancement of hypericin nanoparticle-mediated sonoinduced disruption of biofilm and persister cells of Streptococcus mutans by dermcidin-derived peptide DCD-1L</title><author>Pourhajibagher, Maryam ; Parker, Steven ; Pourakbari, Babak ; Valian, Nasrin Keshavarz ; Raoofian, Reza ; Bahador, Abbas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-e8a618d03e36ffbd86ab5b2545776e073b41b9bbf34ee2afe13ba5d4a679c3973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Anti-Infective Agents - pharmacology</topic><topic>Antimicrobial sonodynamic therapy</topic><topic>Biofilms</topic><topic>ComDE</topic><topic>Dental Caries</topic><topic>Dermcidins - metabolism</topic><topic>Dermcidins - pharmacology</topic><topic>GtfD</topic><topic>Humans</topic><topic>Persister cells</topic><topic>Photochemotherapy - methods</topic><topic>Photosensitizing Agents - pharmacology</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>SmuT</topic><topic>Streptococcus mutans</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pourhajibagher, Maryam</creatorcontrib><creatorcontrib>Parker, Steven</creatorcontrib><creatorcontrib>Pourakbari, Babak</creatorcontrib><creatorcontrib>Valian, Nasrin Keshavarz</creatorcontrib><creatorcontrib>Raoofian, Reza</creatorcontrib><creatorcontrib>Bahador, Abbas</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Photodiagnosis and photodynamic therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pourhajibagher, Maryam</au><au>Parker, Steven</au><au>Pourakbari, Babak</au><au>Valian, Nasrin Keshavarz</au><au>Raoofian, Reza</au><au>Bahador, Abbas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhancement of hypericin nanoparticle-mediated sonoinduced disruption of biofilm and persister cells of Streptococcus mutans by dermcidin-derived peptide DCD-1L</atitle><jtitle>Photodiagnosis and photodynamic therapy</jtitle><addtitle>Photodiagnosis Photodyn Ther</addtitle><date>2023-03</date><risdate>2023</risdate><volume>41</volume><spage>103308</spage><epage>103308</epage><pages>103308-103308</pages><artnum>103308</artnum><issn>1572-1000</issn><eissn>1873-1597</eissn><abstract>•The amount of ROS produced by HypNP-DCD-1 L with the ultrasound waves increased 4.2-fold.•The combination of ultrasound waves with HypNP-DCD-1 L significantly degraded S. mutans biofilm by 5.1 log10 CFU/mL.•HypNP-DCD-1L-mediated aSDT can efficiently reduce the pathogenicity of S. mutans via downregulating the biofilm-associated genes.•aSDT using HypNP-DCD-1 L reduce the persistence phenotype by suppressing the expression of genes associated persister cells formation.
Streptococcus mutans is considered a major significant contributor to dental caries and its effective removal is difficult due to the formation of biofilm. Therefore, the development of adjuvant therapeutic strategies with anti-biofilm properties is a promising approach. In the present study, we examined the effect of dermcidin-derived peptide DCD-1 L on the antibacterial activity of hypericin nanoparticle (HypNP)-mediated antimicrobial sonodynamic therapy (aSDT) against persister cells growing- and biofilm cultures of S. mutans.
Following synthesis and confirmation of HypNP, the fractional inhibitory concentration (FIC) index of HypNP and DCD-1 L was determined by checkerboard assay. Cellular uptake of HypNP-DCD-1 L and generation of endogenous reactive oxygen species (ROS) were assessed and followed by the determination of antimicrobial sonoactivity of HypNP-DCD-1 L against persister cells growing- and biofilm cultures of S. mutans. The water-insoluble extracellular polysaccharide (EPS) and expression of the gtfD, comDE, and smuT genes were then evaluated in persister cells growing- and biofilm cultures of S. mutans.
There was a synergistic activity in the combination of HypNP and DCD-1 L against S. mutans with an FIC index value of 0.37. The HypNP-DCD-1L-mediated aSDT also displayed the highest cellular uptake and endogenous ROS generation by bacterial cells. When biofilm and persister cells of S. mutans were treated with HypNP-DCD-1 L and subsequently exposed to ultrasound waves, 5.1 log and 3.8 log reductions, respectively, in bacterial numbers were observed (P<0.05). According to the data, EPS in both persister cells growing- and biofilm cultures of S. mutans were significantly decreased after exposure to the HypNP-DCD-1L-mediated aSDT (P<0.05). In addition, the quantitative real-time PCR data illustrated the high level of similarities in very low-expression profiles of the gtfD before and after all treated groups for persister cells. While, following HypNP-DCD-1L-mediated aSDT treatment, the expression levels of gtfD, comDE, and smuT were significantly lower in treated persister cells growing- and biofilm cultures of S. mutans in comparison with control groups (P<0.05).
Combined, the results of this study indicate that ultrasound waves-activated HypNP-DCD-1 L can sonoinactivate S. mutans biofilms and persister cells, as well as reduce effectively pathogenicity potency of S. mutans. Hence, HypNP-DCD-1L-mediated aSDT may be proposed as a promising adjunctive therapeutic approach for dental caries.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>36709017</pmid><doi>10.1016/j.pdpdt.2023.103308</doi><tpages>1</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1572-1000 |
| ispartof | Photodiagnosis and photodynamic therapy, 2023-03, Vol.41, p.103308-103308, Article 103308 |
| issn | 1572-1000 1873-1597 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2770478408 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Anti-Infective Agents - pharmacology Antimicrobial sonodynamic therapy Biofilms ComDE Dental Caries Dermcidins - metabolism Dermcidins - pharmacology GtfD Humans Persister cells Photochemotherapy - methods Photosensitizing Agents - pharmacology Reactive Oxygen Species - metabolism SmuT Streptococcus mutans |
| title | Enhancement of hypericin nanoparticle-mediated sonoinduced disruption of biofilm and persister cells of Streptococcus mutans by dermcidin-derived peptide DCD-1L |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T11%3A22%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Enhancement%20of%20hypericin%20nanoparticle-mediated%20sonoinduced%20disruption%20of%20biofilm%20and%20persister%20cells%20of%20Streptococcus%20mutans%20by%20dermcidin-derived%20peptide%20DCD-1L&rft.jtitle=Photodiagnosis%20and%20photodynamic%20therapy&rft.au=Pourhajibagher,%20Maryam&rft.date=2023-03&rft.volume=41&rft.spage=103308&rft.epage=103308&rft.pages=103308-103308&rft.artnum=103308&rft.issn=1572-1000&rft.eissn=1873-1597&rft_id=info:doi/10.1016/j.pdpdt.2023.103308&rft_dat=%3Cproquest_cross%3E2770478408%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2770478408&rft_id=info:pmid/36709017&rft_els_id=S1572100023000364&rfr_iscdi=true |