The Prevalence of Inflammatory Bowel Disease in Greenland

The Prevalence of Inflammatory Bowel Disease in Greenland

Abstract Background Inflammatory bowel disease (IBD) is sparsely investigated in Arctic populations. The aim of this study was to estimate the prevalence of ulcerative colitis (UC) and Crohn’s disease (CD) in Greenland. Methods Cross-sectional nationwide data on demography, anthropometry, biochemist...

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Veröffentlicht in:Inflammatory bowel diseases 2023-12, Vol.29 (12), p.1879-1885
Hauptverfasser: Gantzel, Rasmus Hvidbjerg, Vesterdal, Jos Dalvad, Haase, Anne-Mette, Petersen, Alice Juhl, Grønbæk, Henning, Pedersen, Michael Lynge
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container_end_page 1885
container_issue 12
container_start_page 1879
container_title Inflammatory bowel diseases
container_volume 29
creator Gantzel, Rasmus Hvidbjerg
Vesterdal, Jos Dalvad
Haase, Anne-Mette
Petersen, Alice Juhl
Grønbæk, Henning
Pedersen, Michael Lynge
description Abstract Background Inflammatory bowel disease (IBD) is sparsely investigated in Arctic populations. The aim of this study was to estimate the prevalence of ulcerative colitis (UC) and Crohn’s disease (CD) in Greenland. Methods Cross-sectional nationwide data on demography, anthropometry, biochemistry, and pharmacotherapy were extracted from the electronic medical records in Greenland. Diagnoses of UC and CD were based on International Classification of Diseases–Tenth Revision and International Classification of Primary Care–Second Edition coding and treatment with mesalazine. Data from Statistics Greenland were used for prevalence calculations. Results In total, 254 patients in Greenland experienced IBD, with 214 cases of UC and 40 cases of CD. The overall IBD prevalence was 0.45%, distributed as 0.38% with UC and 0.07% with CD. The IBD prevalence was similar across the 5 regions of Greenland. However, a higher prevalence was observed in the region main towns with the largest populations (0.53%) compared with the small towns along the coastline (0.29%). UC patients were prescribed mesalazine treatment with a frequency of 78%. Furthermore, 10% of all IBD patients received treatment with nonspecific immunomodulators and 7% received biologics. Conclusions This study estimates the prevalence and uncovers characteristics of IBD in Greenland. Although CD may be underdiagnosed or less prevalent, the overall prevalence of IBD in Greenland parallels Scandinavian countries and North America. These results boost the knowledge on autoimmune diseases in arctic populations and may guide clinicians in their management of IBD in Greenland. Furthermore, the results may encourage research in IBD across the Arctic regions. Lay Summary The burden of inflammatory bowel disease has never been investigated in Greenland. This nationwide, cross-sectional, register-based study estimates the prevalence of ulcerative colitis and Crohn’s disease in Greenland and reports that the overall prevalence of inflammatory bowel disease in Greenland parallels Western countries.
doi_str_mv 10.1093/ibd/izad002
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The aim of this study was to estimate the prevalence of ulcerative colitis (UC) and Crohn’s disease (CD) in Greenland. Methods Cross-sectional nationwide data on demography, anthropometry, biochemistry, and pharmacotherapy were extracted from the electronic medical records in Greenland. Diagnoses of UC and CD were based on International Classification of Diseases–Tenth Revision and International Classification of Primary Care–Second Edition coding and treatment with mesalazine. Data from Statistics Greenland were used for prevalence calculations. Results In total, 254 patients in Greenland experienced IBD, with 214 cases of UC and 40 cases of CD. The overall IBD prevalence was 0.45%, distributed as 0.38% with UC and 0.07% with CD. The IBD prevalence was similar across the 5 regions of Greenland. However, a higher prevalence was observed in the region main towns with the largest populations (0.53%) compared with the small towns along the coastline (0.29%). UC patients were prescribed mesalazine treatment with a frequency of 78%. Furthermore, 10% of all IBD patients received treatment with nonspecific immunomodulators and 7% received biologics. Conclusions This study estimates the prevalence and uncovers characteristics of IBD in Greenland. Although CD may be underdiagnosed or less prevalent, the overall prevalence of IBD in Greenland parallels Scandinavian countries and North America. These results boost the knowledge on autoimmune diseases in arctic populations and may guide clinicians in their management of IBD in Greenland. Furthermore, the results may encourage research in IBD across the Arctic regions. Lay Summary The burden of inflammatory bowel disease has never been investigated in Greenland. This nationwide, cross-sectional, register-based study estimates the prevalence of ulcerative colitis and Crohn’s disease in Greenland and reports that the overall prevalence of inflammatory bowel disease in Greenland parallels Western countries.</description><identifier>ISSN: 1078-0998</identifier><identifier>EISSN: 1536-4844</identifier><identifier>DOI: 10.1093/ibd/izad002</identifier><identifier>PMID: 36702537</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><ispartof>Inflammatory bowel diseases, 2023-12, Vol.29 (12), p.1879-1885</ispartof><rights>The Author(s) 2023. Published by Oxford University Press on behalf of Crohn’s &amp; Colitis Foundation. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2023</rights><rights>The Author(s) 2023. Published by Oxford University Press on behalf of Crohn’s &amp; Colitis Foundation. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c320t-8c9392a208463ab1df5d50418a033ce53e67bdb9bb3750f3bd0b675e02268cdf3</citedby><cites>FETCH-LOGICAL-c320t-8c9392a208463ab1df5d50418a033ce53e67bdb9bb3750f3bd0b675e02268cdf3</cites><orcidid>0000-0002-4589-6539</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,1585,27926,27927</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36702537$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gantzel, Rasmus Hvidbjerg</creatorcontrib><creatorcontrib>Vesterdal, Jos Dalvad</creatorcontrib><creatorcontrib>Haase, Anne-Mette</creatorcontrib><creatorcontrib>Petersen, Alice Juhl</creatorcontrib><creatorcontrib>Grønbæk, Henning</creatorcontrib><creatorcontrib>Pedersen, Michael Lynge</creatorcontrib><title>The Prevalence of Inflammatory Bowel Disease in Greenland</title><title>Inflammatory bowel diseases</title><addtitle>Inflamm Bowel Dis</addtitle><description>Abstract Background Inflammatory bowel disease (IBD) is sparsely investigated in Arctic populations. The aim of this study was to estimate the prevalence of ulcerative colitis (UC) and Crohn’s disease (CD) in Greenland. Methods Cross-sectional nationwide data on demography, anthropometry, biochemistry, and pharmacotherapy were extracted from the electronic medical records in Greenland. Diagnoses of UC and CD were based on International Classification of Diseases–Tenth Revision and International Classification of Primary Care–Second Edition coding and treatment with mesalazine. Data from Statistics Greenland were used for prevalence calculations. Results In total, 254 patients in Greenland experienced IBD, with 214 cases of UC and 40 cases of CD. The overall IBD prevalence was 0.45%, distributed as 0.38% with UC and 0.07% with CD. The IBD prevalence was similar across the 5 regions of Greenland. However, a higher prevalence was observed in the region main towns with the largest populations (0.53%) compared with the small towns along the coastline (0.29%). UC patients were prescribed mesalazine treatment with a frequency of 78%. Furthermore, 10% of all IBD patients received treatment with nonspecific immunomodulators and 7% received biologics. Conclusions This study estimates the prevalence and uncovers characteristics of IBD in Greenland. Although CD may be underdiagnosed or less prevalent, the overall prevalence of IBD in Greenland parallels Scandinavian countries and North America. These results boost the knowledge on autoimmune diseases in arctic populations and may guide clinicians in their management of IBD in Greenland. Furthermore, the results may encourage research in IBD across the Arctic regions. Lay Summary The burden of inflammatory bowel disease has never been investigated in Greenland. This nationwide, cross-sectional, register-based study estimates the prevalence of ulcerative colitis and Crohn’s disease in Greenland and reports that the overall prevalence of inflammatory bowel disease in Greenland parallels Western countries.</description><issn>1078-0998</issn><issn>1536-4844</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kM9LwzAUgIMobv44eZeeRJC6l6RpmqNOnYOBHua5JM0rVtpmJqsy_3ojmx7lHd47fHw8PkLOKFxTUHzSGDtpvrQFYHtkTAXP06zIsv14gyxSUKoYkaMQ3iIQRx2SEc8lMMHlmKjlKybPHj90i32FiauTeV-3uuv02vlNcus-sU3umoA6YNL0ycwj9q3u7Qk5qHUb8HS3j8nLw_1y-pgunmbz6c0irTiDdVpUiiumGRRZzrWhthZWQEYLDZxXKDjm0lijjOFSQM2NBZNLgcBYXlS25sfkcutdefc-YFiXXRMqbOMP6IZQMimBMkozFdGrLVp5F4LHulz5ptN-U1Iof1qVsVW5axXp8514MB3aP_Y3TgQutoAbVv-avgEZiXFX</recordid><startdate>20231205</startdate><enddate>20231205</enddate><creator>Gantzel, Rasmus Hvidbjerg</creator><creator>Vesterdal, Jos Dalvad</creator><creator>Haase, Anne-Mette</creator><creator>Petersen, Alice Juhl</creator><creator>Grønbæk, Henning</creator><creator>Pedersen, Michael Lynge</creator><general>Oxford University Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4589-6539</orcidid></search><sort><creationdate>20231205</creationdate><title>The Prevalence of Inflammatory Bowel Disease in Greenland</title><author>Gantzel, Rasmus Hvidbjerg ; Vesterdal, Jos Dalvad ; Haase, Anne-Mette ; Petersen, Alice Juhl ; Grønbæk, Henning ; Pedersen, Michael Lynge</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c320t-8c9392a208463ab1df5d50418a033ce53e67bdb9bb3750f3bd0b675e02268cdf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gantzel, Rasmus Hvidbjerg</creatorcontrib><creatorcontrib>Vesterdal, Jos Dalvad</creatorcontrib><creatorcontrib>Haase, Anne-Mette</creatorcontrib><creatorcontrib>Petersen, Alice Juhl</creatorcontrib><creatorcontrib>Grønbæk, Henning</creatorcontrib><creatorcontrib>Pedersen, Michael Lynge</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Inflammatory bowel diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gantzel, Rasmus Hvidbjerg</au><au>Vesterdal, Jos Dalvad</au><au>Haase, Anne-Mette</au><au>Petersen, Alice Juhl</au><au>Grønbæk, Henning</au><au>Pedersen, Michael Lynge</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Prevalence of Inflammatory Bowel Disease in Greenland</atitle><jtitle>Inflammatory bowel diseases</jtitle><addtitle>Inflamm Bowel Dis</addtitle><date>2023-12-05</date><risdate>2023</risdate><volume>29</volume><issue>12</issue><spage>1879</spage><epage>1885</epage><pages>1879-1885</pages><issn>1078-0998</issn><eissn>1536-4844</eissn><abstract>Abstract Background Inflammatory bowel disease (IBD) is sparsely investigated in Arctic populations. The aim of this study was to estimate the prevalence of ulcerative colitis (UC) and Crohn’s disease (CD) in Greenland. Methods Cross-sectional nationwide data on demography, anthropometry, biochemistry, and pharmacotherapy were extracted from the electronic medical records in Greenland. Diagnoses of UC and CD were based on International Classification of Diseases–Tenth Revision and International Classification of Primary Care–Second Edition coding and treatment with mesalazine. Data from Statistics Greenland were used for prevalence calculations. Results In total, 254 patients in Greenland experienced IBD, with 214 cases of UC and 40 cases of CD. The overall IBD prevalence was 0.45%, distributed as 0.38% with UC and 0.07% with CD. The IBD prevalence was similar across the 5 regions of Greenland. However, a higher prevalence was observed in the region main towns with the largest populations (0.53%) compared with the small towns along the coastline (0.29%). UC patients were prescribed mesalazine treatment with a frequency of 78%. Furthermore, 10% of all IBD patients received treatment with nonspecific immunomodulators and 7% received biologics. Conclusions This study estimates the prevalence and uncovers characteristics of IBD in Greenland. Although CD may be underdiagnosed or less prevalent, the overall prevalence of IBD in Greenland parallels Scandinavian countries and North America. These results boost the knowledge on autoimmune diseases in arctic populations and may guide clinicians in their management of IBD in Greenland. Furthermore, the results may encourage research in IBD across the Arctic regions. Lay Summary The burden of inflammatory bowel disease has never been investigated in Greenland. This nationwide, cross-sectional, register-based study estimates the prevalence of ulcerative colitis and Crohn’s disease in Greenland and reports that the overall prevalence of inflammatory bowel disease in Greenland parallels Western countries.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>36702537</pmid><doi>10.1093/ibd/izad002</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-4589-6539</orcidid></addata></record>
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