Reduction of Proinflammatory Effector Functions Through Remodeling of Fatty Acid Metabolism in CD8+ T Cells From Rheumatoid Arthritis Patients

Objective Rheumatoid arthritis (RA) CD8+ T cells maintain their effector proinflammatory phenotype by changing their metabolism toward aerobic glycolysis. However, their massive energy and biosynthesis needs may require additional substrates other than glucose. Since systemic alterations in lipid me...

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Veröffentlicht in:	Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2023-07, Vol.75 (7), p.1098-1109
Hauptverfasser:	Kraus, Franziska V., Keck, Simon, Klika, Karel D., Graf, Jürgen, Carvalho, Rui A., Lorenz, Hanns‐Martin, Souto‐Carneiro, M. Margarida
Format:	Artikel
Sprache:	eng
Schlagworte:	Arthritis Arthritis, Rheumatoid Autoimmune diseases Biosynthesis CD8 antigen CD8-Positive T-Lymphocytes - metabolism Cell growth Cell surface Drug development Effector cells Fatty acids Fatty Acids - metabolism Gene expression Genes Glycolysis Humans Immunological memory Inflammation Inflammatory diseases Inhibitors Lipid Metabolism Lipids Lymphocytes Lymphocytes T Memory cells Metabolism Methotrexate Oxidation Peripheral blood Phenotypes Protein transport Proteins Psoriatic arthritis Rheumatic diseases Rheumatoid arthritis Substrates T-Lymphocyte Subsets - metabolism Target recognition Therapeutic targets
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